Are histological alterations observed in the gallbladder precancerous lesions?

Detalhes bibliográficos
Autor(a) principal: Meirelles-Costa, Adriana Lúcia Agnelli
Data de Publicação: 2010
Outros Autores: Bresciani, Claudio José Caldas, Perez, Rodrigo Oliva, Bresciani, Barbara Helou, Siqueira, Sheila Aparecida C., Cecconello, Ivan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/18401
Resumo: INTRODUCTION: Gallbladder cancer, which is characterized by rapid progression and a poor prognosis, is a complex disease to treat. Unfortunately, little is known currently about its etiology or pathogenesis. A better understanding of its carcinogenesis and determining risk factors that lead to its development could help improve the available treatment options. METHOD: Based on this better understanding, the histological alterations (such as acute cholecystitis, adenomyomatosis, xanthogranulomatous cholecystitis, polyps, pyloric metaplasia, intestinal metaplasia, dysplasia, cancer and others) in gallbladders from 1,689 patients who underwent laparoscopic cholecystectomy for cholecystolithiasis were analyzed. The association of these gallbladder histological alterations with clinical data was studied. RESULTS: Gender analysis revealed a greater incidence of inflammatory changes in males, while dysplasia and cancer were only found in women. The incidence of cholesterolosis was greater in the patients 60 years of age and under, and the incidence of adenomyomatosis and gangrene was greater in the elderly patients. A progressive increase in the average age was observed as alterations progressed through pyloric metaplasia, intestinal metaplasia, dysplasia and then cancer, suggesting that the metaplasia-dysplasia-carcinoma sequence may occur in gallbladder cancer. Gallbladder histological alterations were also observed in asymptomatic patients. CONCLUSION: The results of this study suggest that there could be an association between some histological alterations of gallbladder and cancer, and they also suggest that the metaplasia-dysplasia-carcinoma sequence could in fact be true in the case of gallbladder cancer. Nevertheless, further studies directed towards a perfect understanding of gallbladder carcinogenesis are required.
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spelling Are histological alterations observed in the gallbladder precancerous lesions? Gallbladder neoplasmsCholecystectomyLaparoscopicMetaplasiaAdenomyomaCholelithiasis INTRODUCTION: Gallbladder cancer, which is characterized by rapid progression and a poor prognosis, is a complex disease to treat. Unfortunately, little is known currently about its etiology or pathogenesis. A better understanding of its carcinogenesis and determining risk factors that lead to its development could help improve the available treatment options. METHOD: Based on this better understanding, the histological alterations (such as acute cholecystitis, adenomyomatosis, xanthogranulomatous cholecystitis, polyps, pyloric metaplasia, intestinal metaplasia, dysplasia, cancer and others) in gallbladders from 1,689 patients who underwent laparoscopic cholecystectomy for cholecystolithiasis were analyzed. The association of these gallbladder histological alterations with clinical data was studied. RESULTS: Gender analysis revealed a greater incidence of inflammatory changes in males, while dysplasia and cancer were only found in women. The incidence of cholesterolosis was greater in the patients 60 years of age and under, and the incidence of adenomyomatosis and gangrene was greater in the elderly patients. A progressive increase in the average age was observed as alterations progressed through pyloric metaplasia, intestinal metaplasia, dysplasia and then cancer, suggesting that the metaplasia-dysplasia-carcinoma sequence may occur in gallbladder cancer. Gallbladder histological alterations were also observed in asymptomatic patients. CONCLUSION: The results of this study suggest that there could be an association between some histological alterations of gallbladder and cancer, and they also suggest that the metaplasia-dysplasia-carcinoma sequence could in fact be true in the case of gallbladder cancer. Nevertheless, further studies directed towards a perfect understanding of gallbladder carcinogenesis are required. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1840110.1590/S1807-59322010000200005Clinics; Vol. 65 No. 2 (2010); 143-150 Clinics; v. 65 n. 2 (2010); 143-150 Clinics; Vol. 65 Núm. 2 (2010); 143-150 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18401/20464Meirelles-Costa, Adriana Lúcia AgnelliBresciani, Claudio José CaldasPerez, Rodrigo OlivaBresciani, Barbara HelouSiqueira, Sheila Aparecida C.Cecconello, Ivaninfo:eu-repo/semantics/openAccess2012-05-23T11:20:18Zoai:revistas.usp.br:article/18401Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:20:18Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Are histological alterations observed in the gallbladder precancerous lesions?
title Are histological alterations observed in the gallbladder precancerous lesions?
spellingShingle Are histological alterations observed in the gallbladder precancerous lesions?
Meirelles-Costa, Adriana Lúcia Agnelli
Gallbladder neoplasms
Cholecystectomy
Laparoscopic
Metaplasia
Adenomyoma
Cholelithiasis
title_short Are histological alterations observed in the gallbladder precancerous lesions?
title_full Are histological alterations observed in the gallbladder precancerous lesions?
title_fullStr Are histological alterations observed in the gallbladder precancerous lesions?
title_full_unstemmed Are histological alterations observed in the gallbladder precancerous lesions?
title_sort Are histological alterations observed in the gallbladder precancerous lesions?
author Meirelles-Costa, Adriana Lúcia Agnelli
author_facet Meirelles-Costa, Adriana Lúcia Agnelli
Bresciani, Claudio José Caldas
Perez, Rodrigo Oliva
Bresciani, Barbara Helou
Siqueira, Sheila Aparecida C.
Cecconello, Ivan
author_role author
author2 Bresciani, Claudio José Caldas
Perez, Rodrigo Oliva
Bresciani, Barbara Helou
Siqueira, Sheila Aparecida C.
Cecconello, Ivan
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Meirelles-Costa, Adriana Lúcia Agnelli
Bresciani, Claudio José Caldas
Perez, Rodrigo Oliva
Bresciani, Barbara Helou
Siqueira, Sheila Aparecida C.
Cecconello, Ivan
dc.subject.por.fl_str_mv Gallbladder neoplasms
Cholecystectomy
Laparoscopic
Metaplasia
Adenomyoma
Cholelithiasis
topic Gallbladder neoplasms
Cholecystectomy
Laparoscopic
Metaplasia
Adenomyoma
Cholelithiasis
description INTRODUCTION: Gallbladder cancer, which is characterized by rapid progression and a poor prognosis, is a complex disease to treat. Unfortunately, little is known currently about its etiology or pathogenesis. A better understanding of its carcinogenesis and determining risk factors that lead to its development could help improve the available treatment options. METHOD: Based on this better understanding, the histological alterations (such as acute cholecystitis, adenomyomatosis, xanthogranulomatous cholecystitis, polyps, pyloric metaplasia, intestinal metaplasia, dysplasia, cancer and others) in gallbladders from 1,689 patients who underwent laparoscopic cholecystectomy for cholecystolithiasis were analyzed. The association of these gallbladder histological alterations with clinical data was studied. RESULTS: Gender analysis revealed a greater incidence of inflammatory changes in males, while dysplasia and cancer were only found in women. The incidence of cholesterolosis was greater in the patients 60 years of age and under, and the incidence of adenomyomatosis and gangrene was greater in the elderly patients. A progressive increase in the average age was observed as alterations progressed through pyloric metaplasia, intestinal metaplasia, dysplasia and then cancer, suggesting that the metaplasia-dysplasia-carcinoma sequence may occur in gallbladder cancer. Gallbladder histological alterations were also observed in asymptomatic patients. CONCLUSION: The results of this study suggest that there could be an association between some histological alterations of gallbladder and cancer, and they also suggest that the metaplasia-dysplasia-carcinoma sequence could in fact be true in the case of gallbladder cancer. Nevertheless, further studies directed towards a perfect understanding of gallbladder carcinogenesis are required.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18401
10.1590/S1807-59322010000200005
url https://www.revistas.usp.br/clinics/article/view/18401
identifier_str_mv 10.1590/S1807-59322010000200005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18401/20464
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 65 No. 2 (2010); 143-150
Clinics; v. 65 n. 2 (2010); 143-150
Clinics; Vol. 65 Núm. 2 (2010); 143-150
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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