Are histological alterations observed in the gallbladder precancerous lesions?
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/18401 |
Resumo: | INTRODUCTION: Gallbladder cancer, which is characterized by rapid progression and a poor prognosis, is a complex disease to treat. Unfortunately, little is known currently about its etiology or pathogenesis. A better understanding of its carcinogenesis and determining risk factors that lead to its development could help improve the available treatment options. METHOD: Based on this better understanding, the histological alterations (such as acute cholecystitis, adenomyomatosis, xanthogranulomatous cholecystitis, polyps, pyloric metaplasia, intestinal metaplasia, dysplasia, cancer and others) in gallbladders from 1,689 patients who underwent laparoscopic cholecystectomy for cholecystolithiasis were analyzed. The association of these gallbladder histological alterations with clinical data was studied. RESULTS: Gender analysis revealed a greater incidence of inflammatory changes in males, while dysplasia and cancer were only found in women. The incidence of cholesterolosis was greater in the patients 60 years of age and under, and the incidence of adenomyomatosis and gangrene was greater in the elderly patients. A progressive increase in the average age was observed as alterations progressed through pyloric metaplasia, intestinal metaplasia, dysplasia and then cancer, suggesting that the metaplasia-dysplasia-carcinoma sequence may occur in gallbladder cancer. Gallbladder histological alterations were also observed in asymptomatic patients. CONCLUSION: The results of this study suggest that there could be an association between some histological alterations of gallbladder and cancer, and they also suggest that the metaplasia-dysplasia-carcinoma sequence could in fact be true in the case of gallbladder cancer. Nevertheless, further studies directed towards a perfect understanding of gallbladder carcinogenesis are required. |
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Clinics |
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Are histological alterations observed in the gallbladder precancerous lesions? Gallbladder neoplasmsCholecystectomyLaparoscopicMetaplasiaAdenomyomaCholelithiasis INTRODUCTION: Gallbladder cancer, which is characterized by rapid progression and a poor prognosis, is a complex disease to treat. Unfortunately, little is known currently about its etiology or pathogenesis. A better understanding of its carcinogenesis and determining risk factors that lead to its development could help improve the available treatment options. METHOD: Based on this better understanding, the histological alterations (such as acute cholecystitis, adenomyomatosis, xanthogranulomatous cholecystitis, polyps, pyloric metaplasia, intestinal metaplasia, dysplasia, cancer and others) in gallbladders from 1,689 patients who underwent laparoscopic cholecystectomy for cholecystolithiasis were analyzed. The association of these gallbladder histological alterations with clinical data was studied. RESULTS: Gender analysis revealed a greater incidence of inflammatory changes in males, while dysplasia and cancer were only found in women. The incidence of cholesterolosis was greater in the patients 60 years of age and under, and the incidence of adenomyomatosis and gangrene was greater in the elderly patients. A progressive increase in the average age was observed as alterations progressed through pyloric metaplasia, intestinal metaplasia, dysplasia and then cancer, suggesting that the metaplasia-dysplasia-carcinoma sequence may occur in gallbladder cancer. Gallbladder histological alterations were also observed in asymptomatic patients. CONCLUSION: The results of this study suggest that there could be an association between some histological alterations of gallbladder and cancer, and they also suggest that the metaplasia-dysplasia-carcinoma sequence could in fact be true in the case of gallbladder cancer. Nevertheless, further studies directed towards a perfect understanding of gallbladder carcinogenesis are required. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1840110.1590/S1807-59322010000200005Clinics; Vol. 65 No. 2 (2010); 143-150 Clinics; v. 65 n. 2 (2010); 143-150 Clinics; Vol. 65 Núm. 2 (2010); 143-150 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18401/20464Meirelles-Costa, Adriana Lúcia AgnelliBresciani, Claudio José CaldasPerez, Rodrigo OlivaBresciani, Barbara HelouSiqueira, Sheila Aparecida C.Cecconello, Ivaninfo:eu-repo/semantics/openAccess2012-05-23T11:20:18Zoai:revistas.usp.br:article/18401Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:20:18Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Are histological alterations observed in the gallbladder precancerous lesions? |
title |
Are histological alterations observed in the gallbladder precancerous lesions? |
spellingShingle |
Are histological alterations observed in the gallbladder precancerous lesions? Meirelles-Costa, Adriana Lúcia Agnelli Gallbladder neoplasms Cholecystectomy Laparoscopic Metaplasia Adenomyoma Cholelithiasis |
title_short |
Are histological alterations observed in the gallbladder precancerous lesions? |
title_full |
Are histological alterations observed in the gallbladder precancerous lesions? |
title_fullStr |
Are histological alterations observed in the gallbladder precancerous lesions? |
title_full_unstemmed |
Are histological alterations observed in the gallbladder precancerous lesions? |
title_sort |
Are histological alterations observed in the gallbladder precancerous lesions? |
author |
Meirelles-Costa, Adriana Lúcia Agnelli |
author_facet |
Meirelles-Costa, Adriana Lúcia Agnelli Bresciani, Claudio José Caldas Perez, Rodrigo Oliva Bresciani, Barbara Helou Siqueira, Sheila Aparecida C. Cecconello, Ivan |
author_role |
author |
author2 |
Bresciani, Claudio José Caldas Perez, Rodrigo Oliva Bresciani, Barbara Helou Siqueira, Sheila Aparecida C. Cecconello, Ivan |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Meirelles-Costa, Adriana Lúcia Agnelli Bresciani, Claudio José Caldas Perez, Rodrigo Oliva Bresciani, Barbara Helou Siqueira, Sheila Aparecida C. Cecconello, Ivan |
dc.subject.por.fl_str_mv |
Gallbladder neoplasms Cholecystectomy Laparoscopic Metaplasia Adenomyoma Cholelithiasis |
topic |
Gallbladder neoplasms Cholecystectomy Laparoscopic Metaplasia Adenomyoma Cholelithiasis |
description |
INTRODUCTION: Gallbladder cancer, which is characterized by rapid progression and a poor prognosis, is a complex disease to treat. Unfortunately, little is known currently about its etiology or pathogenesis. A better understanding of its carcinogenesis and determining risk factors that lead to its development could help improve the available treatment options. METHOD: Based on this better understanding, the histological alterations (such as acute cholecystitis, adenomyomatosis, xanthogranulomatous cholecystitis, polyps, pyloric metaplasia, intestinal metaplasia, dysplasia, cancer and others) in gallbladders from 1,689 patients who underwent laparoscopic cholecystectomy for cholecystolithiasis were analyzed. The association of these gallbladder histological alterations with clinical data was studied. RESULTS: Gender analysis revealed a greater incidence of inflammatory changes in males, while dysplasia and cancer were only found in women. The incidence of cholesterolosis was greater in the patients 60 years of age and under, and the incidence of adenomyomatosis and gangrene was greater in the elderly patients. A progressive increase in the average age was observed as alterations progressed through pyloric metaplasia, intestinal metaplasia, dysplasia and then cancer, suggesting that the metaplasia-dysplasia-carcinoma sequence may occur in gallbladder cancer. Gallbladder histological alterations were also observed in asymptomatic patients. CONCLUSION: The results of this study suggest that there could be an association between some histological alterations of gallbladder and cancer, and they also suggest that the metaplasia-dysplasia-carcinoma sequence could in fact be true in the case of gallbladder cancer. Nevertheless, further studies directed towards a perfect understanding of gallbladder carcinogenesis are required. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18401 10.1590/S1807-59322010000200005 |
url |
https://www.revistas.usp.br/clinics/article/view/18401 |
identifier_str_mv |
10.1590/S1807-59322010000200005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18401/20464 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 65 No. 2 (2010); 143-150 Clinics; v. 65 n. 2 (2010); 143-150 Clinics; Vol. 65 Núm. 2 (2010); 143-150 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222755269902336 |