Treatment of essential hypertension does not normalize capillary rarefaction

Detalhes bibliográficos
Autor(a) principal: Penna, Guilherme Loures de Araújo
Data de Publicação: 2008
Outros Autores: Garbero, Rodrigo de Freitas, Neves, Mario Fritsch, Oigman, Wille, Bottino, Daniel Alexandre, Bouskela, Eliete
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/17750
Resumo: OBJECTIVES: To determine if capillary rarefaction persists when hypertension is treated with angiotensin converting enzyme inhibitor, thiazidic diuretic and/or beta-blocker, and to identify which microcirculatory alterations (structural and functional) persist after anti-hypertensive treatment. METHODS: We evaluated 28 well-controlled essential hypertensive patients and 19 normotensive subjects. Nailfold videocapillaroscopy examination of the fourth finger of the left hand was used to determine the functional capillary densities at baseline, during post-occlusive hyperemia, and after venous congestion. Capillary loop diameters (afferent, apical and efferent) and red blood cell velocity were also quantified. RESULTS: Compared with normotensive subjects, hypertensive patients showed lower mean functional capillary density at baseline (25.1±1.4 vs. 33.9±1.9 cap/mm², p
id USP-19_ae53963c7e190f15d41403d6e6264195
oai_identifier_str oai:revistas.usp.br:article/17750
network_acronym_str USP-19
network_name_str Clinics
repository_id_str
spelling Treatment of essential hypertension does not normalize capillary rarefaction Anti-hypertensive drugsMicrocirculationMicrovascular dysfunctionVideocapillaroscopy OBJECTIVES: To determine if capillary rarefaction persists when hypertension is treated with angiotensin converting enzyme inhibitor, thiazidic diuretic and/or beta-blocker, and to identify which microcirculatory alterations (structural and functional) persist after anti-hypertensive treatment. METHODS: We evaluated 28 well-controlled essential hypertensive patients and 19 normotensive subjects. Nailfold videocapillaroscopy examination of the fourth finger of the left hand was used to determine the functional capillary densities at baseline, during post-occlusive hyperemia, and after venous congestion. Capillary loop diameters (afferent, apical and efferent) and red blood cell velocity were also quantified. RESULTS: Compared with normotensive subjects, hypertensive patients showed lower mean functional capillary density at baseline (25.1±1.4 vs. 33.9±1.9 cap/mm², pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1775010.1590/S1807-59322008000500008Clinics; Vol. 63 No. 5 (2008); 613-618 Clinics; v. 63 n. 5 (2008); 613-618 Clinics; Vol. 63 Núm. 5 (2008); 613-618 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17750/19815Penna, Guilherme Loures de AraújoGarbero, Rodrigo de FreitasNeves, Mario FritschOigman, WilleBottino, Daniel AlexandreBouskela, Elieteinfo:eu-repo/semantics/openAccess2012-05-22T18:30:32Zoai:revistas.usp.br:article/17750Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:30:32Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Treatment of essential hypertension does not normalize capillary rarefaction
title Treatment of essential hypertension does not normalize capillary rarefaction
spellingShingle Treatment of essential hypertension does not normalize capillary rarefaction
Penna, Guilherme Loures de Araújo
Anti-hypertensive drugs
Microcirculation
Microvascular dysfunction
Videocapillaroscopy
title_short Treatment of essential hypertension does not normalize capillary rarefaction
title_full Treatment of essential hypertension does not normalize capillary rarefaction
title_fullStr Treatment of essential hypertension does not normalize capillary rarefaction
title_full_unstemmed Treatment of essential hypertension does not normalize capillary rarefaction
title_sort Treatment of essential hypertension does not normalize capillary rarefaction
author Penna, Guilherme Loures de Araújo
author_facet Penna, Guilherme Loures de Araújo
Garbero, Rodrigo de Freitas
Neves, Mario Fritsch
Oigman, Wille
Bottino, Daniel Alexandre
Bouskela, Eliete
author_role author
author2 Garbero, Rodrigo de Freitas
Neves, Mario Fritsch
Oigman, Wille
Bottino, Daniel Alexandre
Bouskela, Eliete
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Penna, Guilherme Loures de Araújo
Garbero, Rodrigo de Freitas
Neves, Mario Fritsch
Oigman, Wille
Bottino, Daniel Alexandre
Bouskela, Eliete
dc.subject.por.fl_str_mv Anti-hypertensive drugs
Microcirculation
Microvascular dysfunction
Videocapillaroscopy
topic Anti-hypertensive drugs
Microcirculation
Microvascular dysfunction
Videocapillaroscopy
description OBJECTIVES: To determine if capillary rarefaction persists when hypertension is treated with angiotensin converting enzyme inhibitor, thiazidic diuretic and/or beta-blocker, and to identify which microcirculatory alterations (structural and functional) persist after anti-hypertensive treatment. METHODS: We evaluated 28 well-controlled essential hypertensive patients and 19 normotensive subjects. Nailfold videocapillaroscopy examination of the fourth finger of the left hand was used to determine the functional capillary densities at baseline, during post-occlusive hyperemia, and after venous congestion. Capillary loop diameters (afferent, apical and efferent) and red blood cell velocity were also quantified. RESULTS: Compared with normotensive subjects, hypertensive patients showed lower mean functional capillary density at baseline (25.1±1.4 vs. 33.9±1.9 cap/mm², p
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17750
10.1590/S1807-59322008000500008
url https://www.revistas.usp.br/clinics/article/view/17750
identifier_str_mv 10.1590/S1807-59322008000500008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17750/19815
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 63 No. 5 (2008); 613-618
Clinics; v. 63 n. 5 (2008); 613-618
Clinics; Vol. 63 Núm. 5 (2008); 613-618
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
_version_ 1800222753474740224

Registros relacionados