Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion

Detalhes bibliográficos
Autor(a) principal: Yíldíz, Hamit
Data de Publicação: 2011
Outros Autores: Durmus, Ali Said, Şimşek, Halil, Yaman, Mine
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/19466
Resumo: OBJECTIVES: This study was designed to investigate prevention of contralateral testicular injury with sildenafil citrate after unilateral testicular torsion/detorsion. METHODS: Thirty-seven adult male rats were divided into four groups: sham operated (group 1, n = 7), torsion/detorsion + saline (group 2, n = 10), torsion/detorsion + 0.7 mg of sildenafil citrate (group 3, n = 10) and torsion/detorsion + 1.4 mg of sildenafil citrate (group 4, n = 10). Unilateral testicular torsion was created by rotating the right testis 720º in a clockwise direction for 2 h in other groups, except for group 1, which was served as sham group. After torsion (2 h) and detorsion (2 h) periods, rats were killed. RESULTS: The level of reduced glutathion (GSH) (p
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spelling Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion Testicular torsionIschemia-reperfusion damageSildenafil citrateRat OBJECTIVES: This study was designed to investigate prevention of contralateral testicular injury with sildenafil citrate after unilateral testicular torsion/detorsion. METHODS: Thirty-seven adult male rats were divided into four groups: sham operated (group 1, n = 7), torsion/detorsion + saline (group 2, n = 10), torsion/detorsion + 0.7 mg of sildenafil citrate (group 3, n = 10) and torsion/detorsion + 1.4 mg of sildenafil citrate (group 4, n = 10). Unilateral testicular torsion was created by rotating the right testis 720º in a clockwise direction for 2 h in other groups, except for group 1, which was served as sham group. After torsion (2 h) and detorsion (2 h) periods, rats were killed. RESULTS: The level of reduced glutathion (GSH) (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1946610.1590/S1807-59322011000100024Clinics; Vol. 66 No. 1 (2011); 137-142 Clinics; v. 66 n. 1 (2011); 137-142 Clinics; Vol. 66 Núm. 1 (2011); 137-142 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19466/21529Yíldíz, HamitDurmus, Ali SaidŞimşek, HalilYaman, Mineinfo:eu-repo/semantics/openAccess2012-05-23T16:42:24Zoai:revistas.usp.br:article/19466Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:42:24Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion
title Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion
spellingShingle Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion
Yíldíz, Hamit
Testicular torsion
Ischemia-reperfusion damage
Sildenafil citrate
Rat
title_short Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion
title_full Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion
title_fullStr Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion
title_full_unstemmed Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion
title_sort Protective effect of sildenafil citrate on contralateral testis injury after unilateral testicular torsion/detorsion
author Yíldíz, Hamit
author_facet Yíldíz, Hamit
Durmus, Ali Said
Şimşek, Halil
Yaman, Mine
author_role author
author2 Durmus, Ali Said
Şimşek, Halil
Yaman, Mine
author2_role author
author
author
dc.contributor.author.fl_str_mv Yíldíz, Hamit
Durmus, Ali Said
Şimşek, Halil
Yaman, Mine
dc.subject.por.fl_str_mv Testicular torsion
Ischemia-reperfusion damage
Sildenafil citrate
Rat
topic Testicular torsion
Ischemia-reperfusion damage
Sildenafil citrate
Rat
description OBJECTIVES: This study was designed to investigate prevention of contralateral testicular injury with sildenafil citrate after unilateral testicular torsion/detorsion. METHODS: Thirty-seven adult male rats were divided into four groups: sham operated (group 1, n = 7), torsion/detorsion + saline (group 2, n = 10), torsion/detorsion + 0.7 mg of sildenafil citrate (group 3, n = 10) and torsion/detorsion + 1.4 mg of sildenafil citrate (group 4, n = 10). Unilateral testicular torsion was created by rotating the right testis 720º in a clockwise direction for 2 h in other groups, except for group 1, which was served as sham group. After torsion (2 h) and detorsion (2 h) periods, rats were killed. RESULTS: The level of reduced glutathion (GSH) (p
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19466
10.1590/S1807-59322011000100024
url https://www.revistas.usp.br/clinics/article/view/19466
identifier_str_mv 10.1590/S1807-59322011000100024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19466/21529
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 66 No. 1 (2011); 137-142
Clinics; v. 66 n. 1 (2011); 137-142
Clinics; Vol. 66 Núm. 1 (2011); 137-142
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
_version_ 1800222757314625536

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