A review of the epidemiology and treatment of Merkel cell carcinoma

Detalhes bibliográficos
Autor(a) principal: Duprat, João Pedreira
Data de Publicação: 2011
Outros Autores: Landman, Gilles, Salvajoli, João Victor, Brechtbühl, Eduard Rene
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/19498
Resumo: Merkel cell carcinoma is a very rare and aggressive neoplasm. Due to its rarity, therapeutic guidelines are not well established, especially for regionally advanced disease. Articles in English, French, Italian, Portuguese, and Spanish from the last 20 years were identified in MEDLINE and reviewed. The key word "Merkel" was used for the search, relevant articles were selected, and their references were examined. The most important articles related to epidemiology, genesis and treatment were reviewed. The incidence of Merkel cell carcinoma is increasing due to the advancing age of the population, higher rates of sun exposure and an increasing number of immunocompromised individuals. With regard to etiology, the recently described Merkel Cell polyomavirus is thought to play a role. Either local or regional surgical intervention remains the standard of care, but adjuvant radiotherapy or radiotherapy as a primary treatment have been discussed as reasonable therapeutic options. An update on this rare neoplasia is essential because of its increasing incidence and changing treatment options.
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spelling A review of the epidemiology and treatment of Merkel cell carcinoma CarcinomaMerkel CELLLiterature reviewRadiotherapyPolyomavirus Merkel cell carcinoma is a very rare and aggressive neoplasm. Due to its rarity, therapeutic guidelines are not well established, especially for regionally advanced disease. Articles in English, French, Italian, Portuguese, and Spanish from the last 20 years were identified in MEDLINE and reviewed. The key word "Merkel" was used for the search, relevant articles were selected, and their references were examined. The most important articles related to epidemiology, genesis and treatment were reviewed. The incidence of Merkel cell carcinoma is increasing due to the advancing age of the population, higher rates of sun exposure and an increasing number of immunocompromised individuals. With regard to etiology, the recently described Merkel Cell polyomavirus is thought to play a role. Either local or regional surgical intervention remains the standard of care, but adjuvant radiotherapy or radiotherapy as a primary treatment have been discussed as reasonable therapeutic options. An update on this rare neoplasia is essential because of its increasing incidence and changing treatment options. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1949810.1590/S1807-59322011001000023Clinics; Vol. 66 No. 10 (2011); 1817-1823 Clinics; v. 66 n. 10 (2011); 1817-1823 Clinics; Vol. 66 Núm. 10 (2011); 1817-1823 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19498/21561Duprat, João PedreiraLandman, GillesSalvajoli, João VictorBrechtbühl, Eduard Reneinfo:eu-repo/semantics/openAccess2012-05-23T16:44:10Zoai:revistas.usp.br:article/19498Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:44:10Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv A review of the epidemiology and treatment of Merkel cell carcinoma
title A review of the epidemiology and treatment of Merkel cell carcinoma
spellingShingle A review of the epidemiology and treatment of Merkel cell carcinoma
Duprat, João Pedreira
Carcinoma
Merkel CELL
Literature review
Radiotherapy
Polyomavirus
title_short A review of the epidemiology and treatment of Merkel cell carcinoma
title_full A review of the epidemiology and treatment of Merkel cell carcinoma
title_fullStr A review of the epidemiology and treatment of Merkel cell carcinoma
title_full_unstemmed A review of the epidemiology and treatment of Merkel cell carcinoma
title_sort A review of the epidemiology and treatment of Merkel cell carcinoma
author Duprat, João Pedreira
author_facet Duprat, João Pedreira
Landman, Gilles
Salvajoli, João Victor
Brechtbühl, Eduard Rene
author_role author
author2 Landman, Gilles
Salvajoli, João Victor
Brechtbühl, Eduard Rene
author2_role author
author
author
dc.contributor.author.fl_str_mv Duprat, João Pedreira
Landman, Gilles
Salvajoli, João Victor
Brechtbühl, Eduard Rene
dc.subject.por.fl_str_mv Carcinoma
Merkel CELL
Literature review
Radiotherapy
Polyomavirus
topic Carcinoma
Merkel CELL
Literature review
Radiotherapy
Polyomavirus
description Merkel cell carcinoma is a very rare and aggressive neoplasm. Due to its rarity, therapeutic guidelines are not well established, especially for regionally advanced disease. Articles in English, French, Italian, Portuguese, and Spanish from the last 20 years were identified in MEDLINE and reviewed. The key word "Merkel" was used for the search, relevant articles were selected, and their references were examined. The most important articles related to epidemiology, genesis and treatment were reviewed. The incidence of Merkel cell carcinoma is increasing due to the advancing age of the population, higher rates of sun exposure and an increasing number of immunocompromised individuals. With regard to etiology, the recently described Merkel Cell polyomavirus is thought to play a role. Either local or regional surgical intervention remains the standard of care, but adjuvant radiotherapy or radiotherapy as a primary treatment have been discussed as reasonable therapeutic options. An update on this rare neoplasia is essential because of its increasing incidence and changing treatment options.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19498
10.1590/S1807-59322011001000023
url https://www.revistas.usp.br/clinics/article/view/19498
identifier_str_mv 10.1590/S1807-59322011001000023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19498/21561
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 66 No. 10 (2011); 1817-1823
Clinics; v. 66 n. 10 (2011); 1817-1823
Clinics; Vol. 66 Núm. 10 (2011); 1817-1823
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
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