A review of the epidemiology and treatment of Merkel cell carcinoma
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/19498 |
Resumo: | Merkel cell carcinoma is a very rare and aggressive neoplasm. Due to its rarity, therapeutic guidelines are not well established, especially for regionally advanced disease. Articles in English, French, Italian, Portuguese, and Spanish from the last 20 years were identified in MEDLINE and reviewed. The key word "Merkel" was used for the search, relevant articles were selected, and their references were examined. The most important articles related to epidemiology, genesis and treatment were reviewed. The incidence of Merkel cell carcinoma is increasing due to the advancing age of the population, higher rates of sun exposure and an increasing number of immunocompromised individuals. With regard to etiology, the recently described Merkel Cell polyomavirus is thought to play a role. Either local or regional surgical intervention remains the standard of care, but adjuvant radiotherapy or radiotherapy as a primary treatment have been discussed as reasonable therapeutic options. An update on this rare neoplasia is essential because of its increasing incidence and changing treatment options. |
id |
USP-19_b02a23df16992f604ff5724065b33cfc |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/19498 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
A review of the epidemiology and treatment of Merkel cell carcinoma CarcinomaMerkel CELLLiterature reviewRadiotherapyPolyomavirus Merkel cell carcinoma is a very rare and aggressive neoplasm. Due to its rarity, therapeutic guidelines are not well established, especially for regionally advanced disease. Articles in English, French, Italian, Portuguese, and Spanish from the last 20 years were identified in MEDLINE and reviewed. The key word "Merkel" was used for the search, relevant articles were selected, and their references were examined. The most important articles related to epidemiology, genesis and treatment were reviewed. The incidence of Merkel cell carcinoma is increasing due to the advancing age of the population, higher rates of sun exposure and an increasing number of immunocompromised individuals. With regard to etiology, the recently described Merkel Cell polyomavirus is thought to play a role. Either local or regional surgical intervention remains the standard of care, but adjuvant radiotherapy or radiotherapy as a primary treatment have been discussed as reasonable therapeutic options. An update on this rare neoplasia is essential because of its increasing incidence and changing treatment options. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1949810.1590/S1807-59322011001000023Clinics; Vol. 66 No. 10 (2011); 1817-1823 Clinics; v. 66 n. 10 (2011); 1817-1823 Clinics; Vol. 66 Núm. 10 (2011); 1817-1823 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19498/21561Duprat, João PedreiraLandman, GillesSalvajoli, João VictorBrechtbühl, Eduard Reneinfo:eu-repo/semantics/openAccess2012-05-23T16:44:10Zoai:revistas.usp.br:article/19498Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:44:10Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
A review of the epidemiology and treatment of Merkel cell carcinoma |
title |
A review of the epidemiology and treatment of Merkel cell carcinoma |
spellingShingle |
A review of the epidemiology and treatment of Merkel cell carcinoma Duprat, João Pedreira Carcinoma Merkel CELL Literature review Radiotherapy Polyomavirus |
title_short |
A review of the epidemiology and treatment of Merkel cell carcinoma |
title_full |
A review of the epidemiology and treatment of Merkel cell carcinoma |
title_fullStr |
A review of the epidemiology and treatment of Merkel cell carcinoma |
title_full_unstemmed |
A review of the epidemiology and treatment of Merkel cell carcinoma |
title_sort |
A review of the epidemiology and treatment of Merkel cell carcinoma |
author |
Duprat, João Pedreira |
author_facet |
Duprat, João Pedreira Landman, Gilles Salvajoli, João Victor Brechtbühl, Eduard Rene |
author_role |
author |
author2 |
Landman, Gilles Salvajoli, João Victor Brechtbühl, Eduard Rene |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Duprat, João Pedreira Landman, Gilles Salvajoli, João Victor Brechtbühl, Eduard Rene |
dc.subject.por.fl_str_mv |
Carcinoma Merkel CELL Literature review Radiotherapy Polyomavirus |
topic |
Carcinoma Merkel CELL Literature review Radiotherapy Polyomavirus |
description |
Merkel cell carcinoma is a very rare and aggressive neoplasm. Due to its rarity, therapeutic guidelines are not well established, especially for regionally advanced disease. Articles in English, French, Italian, Portuguese, and Spanish from the last 20 years were identified in MEDLINE and reviewed. The key word "Merkel" was used for the search, relevant articles were selected, and their references were examined. The most important articles related to epidemiology, genesis and treatment were reviewed. The incidence of Merkel cell carcinoma is increasing due to the advancing age of the population, higher rates of sun exposure and an increasing number of immunocompromised individuals. With regard to etiology, the recently described Merkel Cell polyomavirus is thought to play a role. Either local or regional surgical intervention remains the standard of care, but adjuvant radiotherapy or radiotherapy as a primary treatment have been discussed as reasonable therapeutic options. An update on this rare neoplasia is essential because of its increasing incidence and changing treatment options. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19498 10.1590/S1807-59322011001000023 |
url |
https://www.revistas.usp.br/clinics/article/view/19498 |
identifier_str_mv |
10.1590/S1807-59322011001000023 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19498/21561 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 66 No. 10 (2011); 1817-1823 Clinics; v. 66 n. 10 (2011); 1817-1823 Clinics; Vol. 66 Núm. 10 (2011); 1817-1823 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222757361811456 |