Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/96937 |
Resumo: | OBJECTIVES: To investigate an unusual outbreak of tetrodotoxin poisoning in Leizhou, southeast China, a case series analysis was conducted to identify the source of illness. METHODS: A total of 22 individuals experienced symptoms of poisoning, including tongue numbness, dizziness, nausea and limb numbness and weakness. Two toxic species, Amoya caninus and Yongeichthys nebulosus, were morphologically identified from the batches of gobies consumed by the patients. Tetrodotoxin levels in the blood and Goby fish samples were detected using liquid chromatography-tandem mass spectrometry. RESULTS: The tetrodotoxin levels in the remaining cooked Goby fish were determined to be 2090.12 µg/kg. For Amoya caninus, the toxicity levels were 1858.29 µg/kg in the muscle and 1997.19 µg/kg in the viscera and for Yongeichthys nebulosus, they were 2783.00 µg/kg in the muscle and 2966.21 µg/kg in the viscera. CONCLUSION: This outbreak demonstrates an underestimation of the risk of Goby fish poisoning. Furthermore, the relationships among the toxic species, climates and marine algae present should be clarified in the future. |
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oai:revistas.usp.br:article/96937 |
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Clinics |
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Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis OBJECTIVES: To investigate an unusual outbreak of tetrodotoxin poisoning in Leizhou, southeast China, a case series analysis was conducted to identify the source of illness. METHODS: A total of 22 individuals experienced symptoms of poisoning, including tongue numbness, dizziness, nausea and limb numbness and weakness. Two toxic species, Amoya caninus and Yongeichthys nebulosus, were morphologically identified from the batches of gobies consumed by the patients. Tetrodotoxin levels in the blood and Goby fish samples were detected using liquid chromatography-tandem mass spectrometry. RESULTS: The tetrodotoxin levels in the remaining cooked Goby fish were determined to be 2090.12 µg/kg. For Amoya caninus, the toxicity levels were 1858.29 µg/kg in the muscle and 1997.19 µg/kg in the viscera and for Yongeichthys nebulosus, they were 2783.00 µg/kg in the muscle and 2966.21 µg/kg in the viscera. CONCLUSION: This outbreak demonstrates an underestimation of the risk of Goby fish poisoning. Furthermore, the relationships among the toxic species, climates and marine algae present should be clarified in the future. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/9693710.6061/clinics/2015(01)05Clinics; Vol. 70 No. 1 (2015); 24-29Clinics; v. 70 n. 1 (2015); 24-29Clinics; Vol. 70 Núm. 1 (2015); 24-291980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/96937/96017Copyright (c) 2015 Clinicsinfo:eu-repo/semantics/openAccessYou, Jie Yue, YaJun Xing, Feng Xia, Wei Lai, ShaoYang Zhang, FengLei 2015-03-27T19:04:38Zoai:revistas.usp.br:article/96937Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2015-03-27T19:04:38Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis |
title |
Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis |
spellingShingle |
Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis You, Jie |
title_short |
Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis |
title_full |
Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis |
title_fullStr |
Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis |
title_full_unstemmed |
Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis |
title_sort |
Tetrodotoxin poisoning caused by Goby fish consumption in southeast China: a retrospective case series analysis |
author |
You, Jie |
author_facet |
You, Jie Yue, YaJun Xing, Feng Xia, Wei Lai, ShaoYang Zhang, FengLei |
author_role |
author |
author2 |
Yue, YaJun Xing, Feng Xia, Wei Lai, ShaoYang Zhang, FengLei |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
You, Jie Yue, YaJun Xing, Feng Xia, Wei Lai, ShaoYang Zhang, FengLei |
description |
OBJECTIVES: To investigate an unusual outbreak of tetrodotoxin poisoning in Leizhou, southeast China, a case series analysis was conducted to identify the source of illness. METHODS: A total of 22 individuals experienced symptoms of poisoning, including tongue numbness, dizziness, nausea and limb numbness and weakness. Two toxic species, Amoya caninus and Yongeichthys nebulosus, were morphologically identified from the batches of gobies consumed by the patients. Tetrodotoxin levels in the blood and Goby fish samples were detected using liquid chromatography-tandem mass spectrometry. RESULTS: The tetrodotoxin levels in the remaining cooked Goby fish were determined to be 2090.12 µg/kg. For Amoya caninus, the toxicity levels were 1858.29 µg/kg in the muscle and 1997.19 µg/kg in the viscera and for Yongeichthys nebulosus, they were 2783.00 µg/kg in the muscle and 2966.21 µg/kg in the viscera. CONCLUSION: This outbreak demonstrates an underestimation of the risk of Goby fish poisoning. Furthermore, the relationships among the toxic species, climates and marine algae present should be clarified in the future. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/96937 10.6061/clinics/2015(01)05 |
url |
https://www.revistas.usp.br/clinics/article/view/96937 |
identifier_str_mv |
10.6061/clinics/2015(01)05 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/96937/96017 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2015 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2015 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 70 No. 1 (2015); 24-29 Clinics; v. 70 n. 1 (2015); 24-29 Clinics; Vol. 70 Núm. 1 (2015); 24-29 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222761682993152 |