Cardiovascular risk in children and adolescents with end stage renal disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/159389 |
Resumo: | OBJECTIVES: To evaluate cardiovascular involvement in children and adolescents with End Stage Renal Disease (ESRD) and to characterize the main risk factors associated with this outcome. METHODS: Cross-sectional study of 69 children and adolescents at renal transplantation and 33 healthy individuals matched by age and gender. The study outcomes were left ventricular mass z-score (LVMZ) and carotid artery intima-media thickness (CIMT). The potential risk factors considered were age, gender, CKD etiology, use of oral vitamin D and calcium-based phosphate binders, systolic and diastolic blood pressure, body mass index z-score, time since diagnosis, dialysis duration, serum levels of ionic calcium, phosphorus, parathyroid hormone, fibroblast growth factor (FGF 23), uric acid, homocysteine, cholesterol, triglycerides, C-reactive protein (CRP), vitamin D and hemoglobin. RESULTS: In the multivariate analysis, the factors associated with LVMZ were dialysis duration, age, systolic blood pressure, serum hemoglobin and HDL cholesterol levels. Regarding CIMT, in the multivariate analysis, systolic blood pressure was the only factor associated with the outcome. CONCLUSION: Children exhibited important cardiovascular involvement at the time of the renal transplantation. Both of the studied outcomes were independently associated with systolic blood pressure. For this reason, controlling blood pressure seems to be the main therapy to minimize cardiovascular involvement in children with ESRD. |
id |
USP-19_b54e6431978f1928b327b39c6f5cd861 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/159389 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Cardiovascular risk in children and adolescents with end stage renal diseaseChronic Kidney DiseaseCardiovascular DiseaseChildrenIntima-Media ThicknessEcocardiographyOBJECTIVES: To evaluate cardiovascular involvement in children and adolescents with End Stage Renal Disease (ESRD) and to characterize the main risk factors associated with this outcome. METHODS: Cross-sectional study of 69 children and adolescents at renal transplantation and 33 healthy individuals matched by age and gender. The study outcomes were left ventricular mass z-score (LVMZ) and carotid artery intima-media thickness (CIMT). The potential risk factors considered were age, gender, CKD etiology, use of oral vitamin D and calcium-based phosphate binders, systolic and diastolic blood pressure, body mass index z-score, time since diagnosis, dialysis duration, serum levels of ionic calcium, phosphorus, parathyroid hormone, fibroblast growth factor (FGF 23), uric acid, homocysteine, cholesterol, triglycerides, C-reactive protein (CRP), vitamin D and hemoglobin. RESULTS: In the multivariate analysis, the factors associated with LVMZ were dialysis duration, age, systolic blood pressure, serum hemoglobin and HDL cholesterol levels. Regarding CIMT, in the multivariate analysis, systolic blood pressure was the only factor associated with the outcome. CONCLUSION: Children exhibited important cardiovascular involvement at the time of the renal transplantation. Both of the studied outcomes were independently associated with systolic blood pressure. For this reason, controlling blood pressure seems to be the main therapy to minimize cardiovascular involvement in children with ESRD.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-06-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/15938910.6061/clinics/2019/e859Clinics; Vol. 74 (2019); e859Clinics; v. 74 (2019); e859Clinics; Vol. 74 (2019); e8591980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/159389/154149https://www.revistas.usp.br/clinics/article/view/159389/154150Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessVal, Maria Luiza doMenezes, Fernanda SouzaMassaoka, Henrique TsuhaScavarda, Valeska TavaresCzapkowski, AdrianoLeite, Heitor PonsMoises, Valdir AmbrósioAjzen, Sergio AronCarvalhaes, João Tomas de AbreuPestana, José Osmar MedinaKoch-Nogueira, Paulo2019-06-26T13:16:08Zoai:revistas.usp.br:article/159389Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-06-26T13:16:08Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Cardiovascular risk in children and adolescents with end stage renal disease |
title |
Cardiovascular risk in children and adolescents with end stage renal disease |
spellingShingle |
Cardiovascular risk in children and adolescents with end stage renal disease Val, Maria Luiza do Chronic Kidney Disease Cardiovascular Disease Children Intima-Media Thickness Ecocardiography |
title_short |
Cardiovascular risk in children and adolescents with end stage renal disease |
title_full |
Cardiovascular risk in children and adolescents with end stage renal disease |
title_fullStr |
Cardiovascular risk in children and adolescents with end stage renal disease |
title_full_unstemmed |
Cardiovascular risk in children and adolescents with end stage renal disease |
title_sort |
Cardiovascular risk in children and adolescents with end stage renal disease |
author |
Val, Maria Luiza do |
author_facet |
Val, Maria Luiza do Menezes, Fernanda Souza Massaoka, Henrique Tsuha Scavarda, Valeska Tavares Czapkowski, Adriano Leite, Heitor Pons Moises, Valdir Ambrósio Ajzen, Sergio Aron Carvalhaes, João Tomas de Abreu Pestana, José Osmar Medina Koch-Nogueira, Paulo |
author_role |
author |
author2 |
Menezes, Fernanda Souza Massaoka, Henrique Tsuha Scavarda, Valeska Tavares Czapkowski, Adriano Leite, Heitor Pons Moises, Valdir Ambrósio Ajzen, Sergio Aron Carvalhaes, João Tomas de Abreu Pestana, José Osmar Medina Koch-Nogueira, Paulo |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Val, Maria Luiza do Menezes, Fernanda Souza Massaoka, Henrique Tsuha Scavarda, Valeska Tavares Czapkowski, Adriano Leite, Heitor Pons Moises, Valdir Ambrósio Ajzen, Sergio Aron Carvalhaes, João Tomas de Abreu Pestana, José Osmar Medina Koch-Nogueira, Paulo |
dc.subject.por.fl_str_mv |
Chronic Kidney Disease Cardiovascular Disease Children Intima-Media Thickness Ecocardiography |
topic |
Chronic Kidney Disease Cardiovascular Disease Children Intima-Media Thickness Ecocardiography |
description |
OBJECTIVES: To evaluate cardiovascular involvement in children and adolescents with End Stage Renal Disease (ESRD) and to characterize the main risk factors associated with this outcome. METHODS: Cross-sectional study of 69 children and adolescents at renal transplantation and 33 healthy individuals matched by age and gender. The study outcomes were left ventricular mass z-score (LVMZ) and carotid artery intima-media thickness (CIMT). The potential risk factors considered were age, gender, CKD etiology, use of oral vitamin D and calcium-based phosphate binders, systolic and diastolic blood pressure, body mass index z-score, time since diagnosis, dialysis duration, serum levels of ionic calcium, phosphorus, parathyroid hormone, fibroblast growth factor (FGF 23), uric acid, homocysteine, cholesterol, triglycerides, C-reactive protein (CRP), vitamin D and hemoglobin. RESULTS: In the multivariate analysis, the factors associated with LVMZ were dialysis duration, age, systolic blood pressure, serum hemoglobin and HDL cholesterol levels. Regarding CIMT, in the multivariate analysis, systolic blood pressure was the only factor associated with the outcome. CONCLUSION: Children exhibited important cardiovascular involvement at the time of the renal transplantation. Both of the studied outcomes were independently associated with systolic blood pressure. For this reason, controlling blood pressure seems to be the main therapy to minimize cardiovascular involvement in children with ESRD. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/159389 10.6061/clinics/2019/e859 |
url |
https://www.revistas.usp.br/clinics/article/view/159389 |
identifier_str_mv |
10.6061/clinics/2019/e859 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/159389/154149 https://www.revistas.usp.br/clinics/article/view/159389/154150 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 74 (2019); e859 Clinics; v. 74 (2019); e859 Clinics; Vol. 74 (2019); e859 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222764181749760 |