microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/174208 |
Resumo: | OBJECTIVES: Retinoblastoma (RB) is a highly malignant eye tumor with a low survival rate and a high metastatic rate. The current work was designed to investigate the potential roles of microRNA-144 (miR-144) in the diagnosis and prognosis of RB. METHODS: miR-144 expression levels in RB tissues and adjacent normal tissues, as well as serum samples from RB patients and healthy controls were measured. The association between miR-144 expression levels and clinical features were analyzed. Moreover, diagnostic and prognostic values of miR-144 in RB were verified by receiver operating characteristic analysis and Kaplan-Meier survival assays. RESULTS: The expression level of miR-144 was markedly decreased in tumor tissues of RB patients, and the expression level of miR-144 was positively associated with tumor size and metastasis in RB patients. Moreover, miR-144 can distinguish tumor tissues from normal tissues with high specificity and sensitivity, and RB patients with lower miR-144 expression have shorter overall and disease-free survival rates than those with higher miR144 expression. Alternatively, miR-144 also decreased in the serum of RB patients in comparison with healthy subjects, and miR-144 expression levels in the tissue samples and serum were positively correlated. Furthermore, miR-144 levels in the serum of RB patients sensitively distinguished RB patients from healthy controls. CONCLUSIONS: miR-144 expression was downregulated in serum and tissue samples of RB patients and may function as a diagnostic and prognostic marker for RB. |
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oai:revistas.usp.br:article/174208 |
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Clinics |
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microRNA-144 functions as a diagnostic and prognostic marker for retinoblastomaRetinoblastomamiR-144DiagnosisPrognosisOBJECTIVES: Retinoblastoma (RB) is a highly malignant eye tumor with a low survival rate and a high metastatic rate. The current work was designed to investigate the potential roles of microRNA-144 (miR-144) in the diagnosis and prognosis of RB. METHODS: miR-144 expression levels in RB tissues and adjacent normal tissues, as well as serum samples from RB patients and healthy controls were measured. The association between miR-144 expression levels and clinical features were analyzed. Moreover, diagnostic and prognostic values of miR-144 in RB were verified by receiver operating characteristic analysis and Kaplan-Meier survival assays. RESULTS: The expression level of miR-144 was markedly decreased in tumor tissues of RB patients, and the expression level of miR-144 was positively associated with tumor size and metastasis in RB patients. Moreover, miR-144 can distinguish tumor tissues from normal tissues with high specificity and sensitivity, and RB patients with lower miR-144 expression have shorter overall and disease-free survival rates than those with higher miR144 expression. Alternatively, miR-144 also decreased in the serum of RB patients in comparison with healthy subjects, and miR-144 expression levels in the tissue samples and serum were positively correlated. Furthermore, miR-144 levels in the serum of RB patients sensitively distinguished RB patients from healthy controls. CONCLUSIONS: miR-144 expression was downregulated in serum and tissue samples of RB patients and may function as a diagnostic and prognostic marker for RB.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2020-08-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/17420810.6061/clinics/2020/e1804Clinics; Vol. 75 (2020); e1804Clinics; v. 75 (2020); e1804Clinics; Vol. 75 (2020); e18041980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/174208/163074https://www.revistas.usp.br/clinics/article/view/174208/163075Copyright (c) 2020 Clinicsinfo:eu-repo/semantics/openAccessZheng, QianZhu, QinLi, CuipingHao, ShuangLi, JianguoYu, XinQi, DengmeiPan, Yu2020-08-27T23:27:46Zoai:revistas.usp.br:article/174208Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2020-08-27T23:27:46Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma |
title |
microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma |
spellingShingle |
microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma Zheng, Qian Retinoblastoma miR-144 Diagnosis Prognosis |
title_short |
microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma |
title_full |
microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma |
title_fullStr |
microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma |
title_full_unstemmed |
microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma |
title_sort |
microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma |
author |
Zheng, Qian |
author_facet |
Zheng, Qian Zhu, Qin Li, Cuiping Hao, Shuang Li, Jianguo Yu, Xin Qi, Dengmei Pan, Yu |
author_role |
author |
author2 |
Zhu, Qin Li, Cuiping Hao, Shuang Li, Jianguo Yu, Xin Qi, Dengmei Pan, Yu |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Zheng, Qian Zhu, Qin Li, Cuiping Hao, Shuang Li, Jianguo Yu, Xin Qi, Dengmei Pan, Yu |
dc.subject.por.fl_str_mv |
Retinoblastoma miR-144 Diagnosis Prognosis |
topic |
Retinoblastoma miR-144 Diagnosis Prognosis |
description |
OBJECTIVES: Retinoblastoma (RB) is a highly malignant eye tumor with a low survival rate and a high metastatic rate. The current work was designed to investigate the potential roles of microRNA-144 (miR-144) in the diagnosis and prognosis of RB. METHODS: miR-144 expression levels in RB tissues and adjacent normal tissues, as well as serum samples from RB patients and healthy controls were measured. The association between miR-144 expression levels and clinical features were analyzed. Moreover, diagnostic and prognostic values of miR-144 in RB were verified by receiver operating characteristic analysis and Kaplan-Meier survival assays. RESULTS: The expression level of miR-144 was markedly decreased in tumor tissues of RB patients, and the expression level of miR-144 was positively associated with tumor size and metastasis in RB patients. Moreover, miR-144 can distinguish tumor tissues from normal tissues with high specificity and sensitivity, and RB patients with lower miR-144 expression have shorter overall and disease-free survival rates than those with higher miR144 expression. Alternatively, miR-144 also decreased in the serum of RB patients in comparison with healthy subjects, and miR-144 expression levels in the tissue samples and serum were positively correlated. Furthermore, miR-144 levels in the serum of RB patients sensitively distinguished RB patients from healthy controls. CONCLUSIONS: miR-144 expression was downregulated in serum and tissue samples of RB patients and may function as a diagnostic and prognostic marker for RB. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/174208 10.6061/clinics/2020/e1804 |
url |
https://www.revistas.usp.br/clinics/article/view/174208 |
identifier_str_mv |
10.6061/clinics/2020/e1804 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/174208/163074 https://www.revistas.usp.br/clinics/article/view/174208/163075 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 75 (2020); e1804 Clinics; v. 75 (2020); e1804 Clinics; Vol. 75 (2020); e1804 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222765215645696 |