microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma

Detalhes bibliográficos
Autor(a) principal: Zheng, Qian
Data de Publicação: 2020
Outros Autores: Zhu, Qin, Li, Cuiping, Hao, Shuang, Li, Jianguo, Yu, Xin, Qi, Dengmei, Pan, Yu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/174208
Resumo: OBJECTIVES: Retinoblastoma (RB) is a highly malignant eye tumor with a low survival rate and a high metastatic rate. The current work was designed to investigate the potential roles of microRNA-144 (miR-144) in the diagnosis and prognosis of RB. METHODS: miR-144 expression levels in RB tissues and adjacent normal tissues, as well as serum samples from RB patients and healthy controls were measured. The association between miR-144 expression levels and clinical features were analyzed. Moreover, diagnostic and prognostic values of miR-144 in RB were verified by receiver operating characteristic analysis and Kaplan-Meier survival assays. RESULTS: The expression level of miR-144 was markedly decreased in tumor tissues of RB patients, and the expression level of miR-144 was positively associated with tumor size and metastasis in RB patients. Moreover, miR-144 can distinguish tumor tissues from normal tissues with high specificity and sensitivity, and RB patients with lower miR-144 expression have shorter overall and disease-free survival rates than those with higher miR144 expression. Alternatively, miR-144 also decreased in the serum of RB patients in comparison with healthy subjects, and miR-144 expression levels in the tissue samples and serum were positively correlated. Furthermore, miR-144 levels in the serum of RB patients sensitively distinguished RB patients from healthy controls. CONCLUSIONS: miR-144 expression was downregulated in serum and tissue samples of RB patients and may function as a diagnostic and prognostic marker for RB.
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spelling microRNA-144 functions as a diagnostic and prognostic marker for retinoblastomaRetinoblastomamiR-144DiagnosisPrognosisOBJECTIVES: Retinoblastoma (RB) is a highly malignant eye tumor with a low survival rate and a high metastatic rate. The current work was designed to investigate the potential roles of microRNA-144 (miR-144) in the diagnosis and prognosis of RB. METHODS: miR-144 expression levels in RB tissues and adjacent normal tissues, as well as serum samples from RB patients and healthy controls were measured. The association between miR-144 expression levels and clinical features were analyzed. Moreover, diagnostic and prognostic values of miR-144 in RB were verified by receiver operating characteristic analysis and Kaplan-Meier survival assays. RESULTS: The expression level of miR-144 was markedly decreased in tumor tissues of RB patients, and the expression level of miR-144 was positively associated with tumor size and metastasis in RB patients. Moreover, miR-144 can distinguish tumor tissues from normal tissues with high specificity and sensitivity, and RB patients with lower miR-144 expression have shorter overall and disease-free survival rates than those with higher miR144 expression. Alternatively, miR-144 also decreased in the serum of RB patients in comparison with healthy subjects, and miR-144 expression levels in the tissue samples and serum were positively correlated. Furthermore, miR-144 levels in the serum of RB patients sensitively distinguished RB patients from healthy controls. CONCLUSIONS: miR-144 expression was downregulated in serum and tissue samples of RB patients and may function as a diagnostic and prognostic marker for RB.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2020-08-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/17420810.6061/clinics/2020/e1804Clinics; Vol. 75 (2020); e1804Clinics; v. 75 (2020); e1804Clinics; Vol. 75 (2020); e18041980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/174208/163074https://www.revistas.usp.br/clinics/article/view/174208/163075Copyright (c) 2020 Clinicsinfo:eu-repo/semantics/openAccessZheng, QianZhu, QinLi, CuipingHao, ShuangLi, JianguoYu, XinQi, DengmeiPan, Yu2020-08-27T23:27:46Zoai:revistas.usp.br:article/174208Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2020-08-27T23:27:46Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma
title microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma
spellingShingle microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma
Zheng, Qian
Retinoblastoma
miR-144
Diagnosis
Prognosis
title_short microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma
title_full microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma
title_fullStr microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma
title_full_unstemmed microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma
title_sort microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma
author Zheng, Qian
author_facet Zheng, Qian
Zhu, Qin
Li, Cuiping
Hao, Shuang
Li, Jianguo
Yu, Xin
Qi, Dengmei
Pan, Yu
author_role author
author2 Zhu, Qin
Li, Cuiping
Hao, Shuang
Li, Jianguo
Yu, Xin
Qi, Dengmei
Pan, Yu
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zheng, Qian
Zhu, Qin
Li, Cuiping
Hao, Shuang
Li, Jianguo
Yu, Xin
Qi, Dengmei
Pan, Yu
dc.subject.por.fl_str_mv Retinoblastoma
miR-144
Diagnosis
Prognosis
topic Retinoblastoma
miR-144
Diagnosis
Prognosis
description OBJECTIVES: Retinoblastoma (RB) is a highly malignant eye tumor with a low survival rate and a high metastatic rate. The current work was designed to investigate the potential roles of microRNA-144 (miR-144) in the diagnosis and prognosis of RB. METHODS: miR-144 expression levels in RB tissues and adjacent normal tissues, as well as serum samples from RB patients and healthy controls were measured. The association between miR-144 expression levels and clinical features were analyzed. Moreover, diagnostic and prognostic values of miR-144 in RB were verified by receiver operating characteristic analysis and Kaplan-Meier survival assays. RESULTS: The expression level of miR-144 was markedly decreased in tumor tissues of RB patients, and the expression level of miR-144 was positively associated with tumor size and metastasis in RB patients. Moreover, miR-144 can distinguish tumor tissues from normal tissues with high specificity and sensitivity, and RB patients with lower miR-144 expression have shorter overall and disease-free survival rates than those with higher miR144 expression. Alternatively, miR-144 also decreased in the serum of RB patients in comparison with healthy subjects, and miR-144 expression levels in the tissue samples and serum were positively correlated. Furthermore, miR-144 levels in the serum of RB patients sensitively distinguished RB patients from healthy controls. CONCLUSIONS: miR-144 expression was downregulated in serum and tissue samples of RB patients and may function as a diagnostic and prognostic marker for RB.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-27
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/174208
10.6061/clinics/2020/e1804
url https://www.revistas.usp.br/clinics/article/view/174208
identifier_str_mv 10.6061/clinics/2020/e1804
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/174208/163074
https://www.revistas.usp.br/clinics/article/view/174208/163075
dc.rights.driver.fl_str_mv Copyright (c) 2020 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/xml
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 75 (2020); e1804
Clinics; v. 75 (2020); e1804
Clinics; Vol. 75 (2020); e1804
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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