Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/19241 |
Resumo: | OBJECTIVE: To evaluate the effect of spironolactone on ventricular stiffness in spontaneously hypertensive adult rats subjected to high salt intake. INTRODUCTION: High salt intake leads to cardiac hypertrophy, collagen accumulation and diastolic dysfunction. These effects are partially mediated by cardiac activation of the renin-angiotensin-aldosterone system. METHODS: Male spontaneously hypertensive rats (SHRs, 32 weeks) received drinking water (SHR), a 1% NaCl solution (SHR-Salt), or a 1% NaCl solution with a daily subcutaneous injection of spironolactone (80 mg.kg-1) (SHRSalt- S). Age-matched normotensive Wistar rats were used as a control. Eight weeks later, the animals were anesthetized and catheterized to evaluate left ventricular and arterial blood pressure. After cardiac arrest, a doublelumen catheter was inserted into the left ventricle through the aorta to obtain in situ left ventricular pressurevolume curves. RESULTS: The blood pressures of all the SHR groups were similar to each other but were different from the normotensive controls (Wistar = 109±2; SHR = 118±2; SHR-Salt = 117±2; SHR-Salt-S = 116±2 mmHg; P |
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Clinics |
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Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake HypertensionSalt IntakeCardiac HypertrophyVentricular StiffnessAldosterone Antagonism OBJECTIVE: To evaluate the effect of spironolactone on ventricular stiffness in spontaneously hypertensive adult rats subjected to high salt intake. INTRODUCTION: High salt intake leads to cardiac hypertrophy, collagen accumulation and diastolic dysfunction. These effects are partially mediated by cardiac activation of the renin-angiotensin-aldosterone system. METHODS: Male spontaneously hypertensive rats (SHRs, 32 weeks) received drinking water (SHR), a 1% NaCl solution (SHR-Salt), or a 1% NaCl solution with a daily subcutaneous injection of spironolactone (80 mg.kg-1) (SHRSalt- S). Age-matched normotensive Wistar rats were used as a control. Eight weeks later, the animals were anesthetized and catheterized to evaluate left ventricular and arterial blood pressure. After cardiac arrest, a doublelumen catheter was inserted into the left ventricle through the aorta to obtain in situ left ventricular pressurevolume curves. RESULTS: The blood pressures of all the SHR groups were similar to each other but were different from the normotensive controls (Wistar = 109±2; SHR = 118±2; SHR-Salt = 117±2; SHR-Salt-S = 116±2 mmHg; PHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1924110.1590/S1807-59322011000300020Clinics; Vol. 66 No. 3 (2011); 477-482 Clinics; v. 66 n. 3 (2011); 477-482 Clinics; Vol. 66 Núm. 3 (2011); 477-482 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19241/21304Baldo, Marcelo PerimZaniqueli, DivaneiForechi, LudimilaMachado, Rebeca CaldeiraRodrigues, Sérgio LamêgoMill, José Geraldoinfo:eu-repo/semantics/openAccess2012-05-23T16:29:33Zoai:revistas.usp.br:article/19241Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:29:33Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake |
title |
Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake |
spellingShingle |
Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake Baldo, Marcelo Perim Hypertension Salt Intake Cardiac Hypertrophy Ventricular Stiffness Aldosterone Antagonism |
title_short |
Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake |
title_full |
Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake |
title_fullStr |
Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake |
title_full_unstemmed |
Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake |
title_sort |
Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake |
author |
Baldo, Marcelo Perim |
author_facet |
Baldo, Marcelo Perim Zaniqueli, Divanei Forechi, Ludimila Machado, Rebeca Caldeira Rodrigues, Sérgio Lamêgo Mill, José Geraldo |
author_role |
author |
author2 |
Zaniqueli, Divanei Forechi, Ludimila Machado, Rebeca Caldeira Rodrigues, Sérgio Lamêgo Mill, José Geraldo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Baldo, Marcelo Perim Zaniqueli, Divanei Forechi, Ludimila Machado, Rebeca Caldeira Rodrigues, Sérgio Lamêgo Mill, José Geraldo |
dc.subject.por.fl_str_mv |
Hypertension Salt Intake Cardiac Hypertrophy Ventricular Stiffness Aldosterone Antagonism |
topic |
Hypertension Salt Intake Cardiac Hypertrophy Ventricular Stiffness Aldosterone Antagonism |
description |
OBJECTIVE: To evaluate the effect of spironolactone on ventricular stiffness in spontaneously hypertensive adult rats subjected to high salt intake. INTRODUCTION: High salt intake leads to cardiac hypertrophy, collagen accumulation and diastolic dysfunction. These effects are partially mediated by cardiac activation of the renin-angiotensin-aldosterone system. METHODS: Male spontaneously hypertensive rats (SHRs, 32 weeks) received drinking water (SHR), a 1% NaCl solution (SHR-Salt), or a 1% NaCl solution with a daily subcutaneous injection of spironolactone (80 mg.kg-1) (SHRSalt- S). Age-matched normotensive Wistar rats were used as a control. Eight weeks later, the animals were anesthetized and catheterized to evaluate left ventricular and arterial blood pressure. After cardiac arrest, a doublelumen catheter was inserted into the left ventricle through the aorta to obtain in situ left ventricular pressurevolume curves. RESULTS: The blood pressures of all the SHR groups were similar to each other but were different from the normotensive controls (Wistar = 109±2; SHR = 118±2; SHR-Salt = 117±2; SHR-Salt-S = 116±2 mmHg; P |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19241 10.1590/S1807-59322011000300020 |
url |
https://www.revistas.usp.br/clinics/article/view/19241 |
identifier_str_mv |
10.1590/S1807-59322011000300020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19241/21304 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 66 No. 3 (2011); 477-482 Clinics; v. 66 n. 3 (2011); 477-482 Clinics; Vol. 66 Núm. 3 (2011); 477-482 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222756294361088 |