Hyperkalemia accompanies hemorrhagic shock and correlates with mortality

• Autor(a) principal: Rocha Filho, Joel Avancini
• Data de Publicação: 2009
• Outros Autores: Nani, Ricardo Souza, D'Albuquerque, Luiz Augusto Carneiro, Holms, Carla Augusto, Rocha, João Plínio Souza, Malbouisson, Luís Marcelo Sá, Machado, Marcel Cerqueira César, Carmona, Maria José Carvalho, Auler Júnior, José Otávio Costa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Clinics
• Texto Completo: https://www.revistas.usp.br/clinics/article/view/18061
• topic: Hemorrhagic Shock; Hyperkalemia; Cardiac Arrest; Mortality; Trauma

OBJECTIVE: This study was designed to evaluate the effects of terlipressin versus fluid resuscitation with normal saline, hypertonic saline or hypertonic-hyperoncotic hydroxyethyl starch, on hemodynamics, metabolics, blood loss and short-term survival in hemorrhagic shock. METHOD: Twenty-nine pigs were subjected to severe liver injury and treated 30 min later with either: (1) 2 mg terlipressin in a bolus, (2) placebo-treated controls, (3) 4 mL/kg 7.5% hypertonic NaCl, (4) 4 mL/kg 7.2% hypertonic-hyperoncotic hydroxyethyl starch 200/0.5, or (5) normal saline at three times lost blood volume. RESULTS: The overall mortality rate was 69%. Blood loss was significantly higher in the hypertonic-hyperoncotic hydroxyethyl starch and normal saline groups than in the terlipressin, hypertonic NaCl and placebo-treated controls groups (p;5 mmol/L) before any treatment occurred in 66% of the patients (80% among non-survivors vs. 22% among survivors, p=0.019). Post-resuscitation hyperkalemia occurred in 86.66% of non-survivors vs. 0% of survivors (p