Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/120609 |
Resumo: | OBJECTIVES: Dengue cases range from asymptomatic to severe, eventually leading to hospitalization and death. Timely and appropriate management is critical to reduce morbidity. Since 1980, dengue has spread throughout Brazil, affecting an increasing number of individuals. This paper describes age and regional differences in dengue’s clinical presentation and associated risk of hospitalization based on more than 5 million cases reported to the Brazilian Ministry of Health from 2000-2014. METHODS: We performed a retrospective analysis of ∼5,450,000 dengue cases, relating clinical manifestations and the risk of hospitalization to age, gender, previous infection by dengue, dengue virus serotype, years of formal education, delay to first attendance and the occurrence of dengue during outbreaks and in different Brazilian regions. RESULTS: Complicated forms of dengue occurred more frequently among those younger than 10 years (3.12% vs 1.92%) and those with dengue virus 2 infection (7.65% vs 2.42%), with a delay to first attendance >;2 days (3.18% vs 0.82%) and with ≤4 years of formal education (2.02% vs 1.46%). The risk of hospitalization was higher among those aged 6-10 years old (OR 4.57; 95% CI 1.43-29.96) and those who were infected by dengue virus 2 (OR 6.36; 95% CI 2.52-16.06), who lived in the Northeast region (OR 1.38; 95% CI 1.11-2.10) and who delayed first attendance by >;5 days (composite OR 3.15; 95% CI 1.33-8.9). CONCLUSIONS: In Brazil, the occurrence of severe dengue and related hospitalization is associated with being younger than 10 years old, being infected by dengue virus 2 or 3, living in the Northeast region (the poorest and the second most populated) and delaying first attendance for more than 2 days. |
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oai:revistas.usp.br:article/120609 |
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USP-19 |
network_name_str |
Clinics |
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|
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Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014 OBJECTIVES: Dengue cases range from asymptomatic to severe, eventually leading to hospitalization and death. Timely and appropriate management is critical to reduce morbidity. Since 1980, dengue has spread throughout Brazil, affecting an increasing number of individuals. This paper describes age and regional differences in dengue’s clinical presentation and associated risk of hospitalization based on more than 5 million cases reported to the Brazilian Ministry of Health from 2000-2014. METHODS: We performed a retrospective analysis of ∼5,450,000 dengue cases, relating clinical manifestations and the risk of hospitalization to age, gender, previous infection by dengue, dengue virus serotype, years of formal education, delay to first attendance and the occurrence of dengue during outbreaks and in different Brazilian regions. RESULTS: Complicated forms of dengue occurred more frequently among those younger than 10 years (3.12% vs 1.92%) and those with dengue virus 2 infection (7.65% vs 2.42%), with a delay to first attendance >;2 days (3.18% vs 0.82%) and with ≤4 years of formal education (2.02% vs 1.46%). The risk of hospitalization was higher among those aged 6-10 years old (OR 4.57; 95% CI 1.43-29.96) and those who were infected by dengue virus 2 (OR 6.36; 95% CI 2.52-16.06), who lived in the Northeast region (OR 1.38; 95% CI 1.11-2.10) and who delayed first attendance by >;5 days (composite OR 3.15; 95% CI 1.33-8.9). CONCLUSIONS: In Brazil, the occurrence of severe dengue and related hospitalization is associated with being younger than 10 years old, being infected by dengue virus 2 or 3, living in the Northeast region (the poorest and the second most populated) and delaying first attendance for more than 2 days. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2016-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/12060910.6061/clinics/2016(08)08Clinics; Vol. 71 No. 8 (2016); 455-463Clinics; v. 71 n. 8 (2016); 455-463Clinics; Vol. 71 Núm. 8 (2016); 455-4631980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/120609/117682Copyright (c) 2016 Clinicsinfo:eu-repo/semantics/openAccessBurattini, Marcelo N.Lopez, Luis F.Coutinho, Francisco A.B.Siqueira-Jr, João B.Homsani, SheilaSarti, ElsaMassad, Eduardo2016-09-12T18:51:49Zoai:revistas.usp.br:article/120609Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2016-09-12T18:51:49Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014 |
title |
Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014 |
spellingShingle |
Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014 Burattini, Marcelo N. |
title_short |
Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014 |
title_full |
Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014 |
title_fullStr |
Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014 |
title_full_unstemmed |
Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014 |
title_sort |
Age and regional differences in clinical presentation and risk of hospitalization for dengue in Brazil, 2000-2014 |
author |
Burattini, Marcelo N. |
author_facet |
Burattini, Marcelo N. Lopez, Luis F. Coutinho, Francisco A.B. Siqueira-Jr, João B. Homsani, Sheila Sarti, Elsa Massad, Eduardo |
author_role |
author |
author2 |
Lopez, Luis F. Coutinho, Francisco A.B. Siqueira-Jr, João B. Homsani, Sheila Sarti, Elsa Massad, Eduardo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Burattini, Marcelo N. Lopez, Luis F. Coutinho, Francisco A.B. Siqueira-Jr, João B. Homsani, Sheila Sarti, Elsa Massad, Eduardo |
description |
OBJECTIVES: Dengue cases range from asymptomatic to severe, eventually leading to hospitalization and death. Timely and appropriate management is critical to reduce morbidity. Since 1980, dengue has spread throughout Brazil, affecting an increasing number of individuals. This paper describes age and regional differences in dengue’s clinical presentation and associated risk of hospitalization based on more than 5 million cases reported to the Brazilian Ministry of Health from 2000-2014. METHODS: We performed a retrospective analysis of ∼5,450,000 dengue cases, relating clinical manifestations and the risk of hospitalization to age, gender, previous infection by dengue, dengue virus serotype, years of formal education, delay to first attendance and the occurrence of dengue during outbreaks and in different Brazilian regions. RESULTS: Complicated forms of dengue occurred more frequently among those younger than 10 years (3.12% vs 1.92%) and those with dengue virus 2 infection (7.65% vs 2.42%), with a delay to first attendance >;2 days (3.18% vs 0.82%) and with ≤4 years of formal education (2.02% vs 1.46%). The risk of hospitalization was higher among those aged 6-10 years old (OR 4.57; 95% CI 1.43-29.96) and those who were infected by dengue virus 2 (OR 6.36; 95% CI 2.52-16.06), who lived in the Northeast region (OR 1.38; 95% CI 1.11-2.10) and who delayed first attendance by >;5 days (composite OR 3.15; 95% CI 1.33-8.9). CONCLUSIONS: In Brazil, the occurrence of severe dengue and related hospitalization is associated with being younger than 10 years old, being infected by dengue virus 2 or 3, living in the Northeast region (the poorest and the second most populated) and delaying first attendance for more than 2 days. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/120609 10.6061/clinics/2016(08)08 |
url |
https://www.revistas.usp.br/clinics/article/view/120609 |
identifier_str_mv |
10.6061/clinics/2016(08)08 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/120609/117682 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2016 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2016 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 71 No. 8 (2016); 455-463 Clinics; v. 71 n. 8 (2016); 455-463 Clinics; Vol. 71 Núm. 8 (2016); 455-463 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222762666557440 |