Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/76988 |
Resumo: | OBJECTIVE: To understand the relationships between brain structures and function (behavior and cognition) in healthy aging. METHOD: The study group was composed of 56 healthy elderly subjects who underwent neuropsychological assessment and quantitative magnetic resonance imaging. Cluster analysis classified the cohort into two groups, one (cluster 1) in which the magnetic resonance imaging metrics were more preserved (mean age: 66.4 years) and another (cluster 2) with less preserved markers of healthy brain tissue (mean age: 75.4 years). RESULTS: The subjects in cluster 2 (older group) had worse indices of interference in the Stroop test compared with the subjects in cluster 1 (younger group). Therefore, a simple test such as the Stroop test could differentiate groups of younger and older subjects based on magnetic resonance imaging metrics. CONCLUSION: These results are in agreement with the inhibitory control hypotheses regarding cognitive aging and may also be important in the interpretation of studies with other clinical groups, such as patients with dementia and mild cognitive impairment. |
id |
USP-19_c4769638bc2eb11425429d3f33676bb5 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/76988 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Magnetic resonance imaging and neuropsychological testing in the spectrum of normal agingOBJECTIVE: To understand the relationships between brain structures and function (behavior and cognition) in healthy aging. METHOD: The study group was composed of 56 healthy elderly subjects who underwent neuropsychological assessment and quantitative magnetic resonance imaging. Cluster analysis classified the cohort into two groups, one (cluster 1) in which the magnetic resonance imaging metrics were more preserved (mean age: 66.4 years) and another (cluster 2) with less preserved markers of healthy brain tissue (mean age: 75.4 years). RESULTS: The subjects in cluster 2 (older group) had worse indices of interference in the Stroop test compared with the subjects in cluster 1 (younger group). Therefore, a simple test such as the Stroop test could differentiate groups of younger and older subjects based on magnetic resonance imaging metrics. CONCLUSION: These results are in agreement with the inhibitory control hypotheses regarding cognitive aging and may also be important in the interpretation of studies with other clinical groups, such as patients with dementia and mild cognitive impairment.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2013-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/7698810.1590/clin.v68i9.76988Clinics; Vol. 68 No. 9 (2013); 1197-1205Clinics; v. 68 n. 9 (2013); 1197-1205Clinics; Vol. 68 Núm. 9 (2013); 1197-12051980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/76988/80849Foss, Maria PaulaDiniz, Paula Rejane BeserraFormigheri, PauloSalmon, Carlos Ernesto GarridoSpeciali, Jose GeraldoSantos, Antonio Carlosinfo:eu-repo/semantics/openAccess2014-03-21T20:07:59Zoai:revistas.usp.br:article/76988Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2014-03-21T20:07:59Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging |
title |
Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging |
spellingShingle |
Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging Foss, Maria Paula |
title_short |
Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging |
title_full |
Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging |
title_fullStr |
Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging |
title_full_unstemmed |
Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging |
title_sort |
Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging |
author |
Foss, Maria Paula |
author_facet |
Foss, Maria Paula Diniz, Paula Rejane Beserra Formigheri, Paulo Salmon, Carlos Ernesto Garrido Speciali, Jose Geraldo Santos, Antonio Carlos |
author_role |
author |
author2 |
Diniz, Paula Rejane Beserra Formigheri, Paulo Salmon, Carlos Ernesto Garrido Speciali, Jose Geraldo Santos, Antonio Carlos |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Foss, Maria Paula Diniz, Paula Rejane Beserra Formigheri, Paulo Salmon, Carlos Ernesto Garrido Speciali, Jose Geraldo Santos, Antonio Carlos |
description |
OBJECTIVE: To understand the relationships between brain structures and function (behavior and cognition) in healthy aging. METHOD: The study group was composed of 56 healthy elderly subjects who underwent neuropsychological assessment and quantitative magnetic resonance imaging. Cluster analysis classified the cohort into two groups, one (cluster 1) in which the magnetic resonance imaging metrics were more preserved (mean age: 66.4 years) and another (cluster 2) with less preserved markers of healthy brain tissue (mean age: 75.4 years). RESULTS: The subjects in cluster 2 (older group) had worse indices of interference in the Stroop test compared with the subjects in cluster 1 (younger group). Therefore, a simple test such as the Stroop test could differentiate groups of younger and older subjects based on magnetic resonance imaging metrics. CONCLUSION: These results are in agreement with the inhibitory control hypotheses regarding cognitive aging and may also be important in the interpretation of studies with other clinical groups, such as patients with dementia and mild cognitive impairment. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/76988 10.1590/clin.v68i9.76988 |
url |
https://www.revistas.usp.br/clinics/article/view/76988 |
identifier_str_mv |
10.1590/clin.v68i9.76988 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/76988/80849 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 68 No. 9 (2013); 1197-1205 Clinics; v. 68 n. 9 (2013); 1197-1205 Clinics; Vol. 68 Núm. 9 (2013); 1197-1205 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222760724594688 |