Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging

Detalhes bibliográficos
Autor(a) principal: Foss, Maria Paula
Data de Publicação: 2013
Outros Autores: Diniz, Paula Rejane Beserra, Formigheri, Paulo, Salmon, Carlos Ernesto Garrido, Speciali, Jose Geraldo, Santos, Antonio Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/76988
Resumo: OBJECTIVE: To understand the relationships between brain structures and function (behavior and cognition) in healthy aging. METHOD: The study group was composed of 56 healthy elderly subjects who underwent neuropsychological assessment and quantitative magnetic resonance imaging. Cluster analysis classified the cohort into two groups, one (cluster 1) in which the magnetic resonance imaging metrics were more preserved (mean age: 66.4 years) and another (cluster 2) with less preserved markers of healthy brain tissue (mean age: 75.4 years). RESULTS: The subjects in cluster 2 (older group) had worse indices of interference in the Stroop test compared with the subjects in cluster 1 (younger group). Therefore, a simple test such as the Stroop test could differentiate groups of younger and older subjects based on magnetic resonance imaging metrics. CONCLUSION: These results are in agreement with the inhibitory control hypotheses regarding cognitive aging and may also be important in the interpretation of studies with other clinical groups, such as patients with dementia and mild cognitive impairment.
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spelling Magnetic resonance imaging and neuropsychological testing in the spectrum of normal agingOBJECTIVE: To understand the relationships between brain structures and function (behavior and cognition) in healthy aging. METHOD: The study group was composed of 56 healthy elderly subjects who underwent neuropsychological assessment and quantitative magnetic resonance imaging. Cluster analysis classified the cohort into two groups, one (cluster 1) in which the magnetic resonance imaging metrics were more preserved (mean age: 66.4 years) and another (cluster 2) with less preserved markers of healthy brain tissue (mean age: 75.4 years). RESULTS: The subjects in cluster 2 (older group) had worse indices of interference in the Stroop test compared with the subjects in cluster 1 (younger group). Therefore, a simple test such as the Stroop test could differentiate groups of younger and older subjects based on magnetic resonance imaging metrics. CONCLUSION: These results are in agreement with the inhibitory control hypotheses regarding cognitive aging and may also be important in the interpretation of studies with other clinical groups, such as patients with dementia and mild cognitive impairment.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2013-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/7698810.1590/clin.v68i9.76988Clinics; Vol. 68 No. 9 (2013); 1197-1205Clinics; v. 68 n. 9 (2013); 1197-1205Clinics; Vol. 68 Núm. 9 (2013); 1197-12051980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/76988/80849Foss, Maria PaulaDiniz, Paula Rejane BeserraFormigheri, PauloSalmon, Carlos Ernesto GarridoSpeciali, Jose GeraldoSantos, Antonio Carlosinfo:eu-repo/semantics/openAccess2014-03-21T20:07:59Zoai:revistas.usp.br:article/76988Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2014-03-21T20:07:59Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging
title Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging
spellingShingle Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging
Foss, Maria Paula
title_short Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging
title_full Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging
title_fullStr Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging
title_full_unstemmed Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging
title_sort Magnetic resonance imaging and neuropsychological testing in the spectrum of normal aging
author Foss, Maria Paula
author_facet Foss, Maria Paula
Diniz, Paula Rejane Beserra
Formigheri, Paulo
Salmon, Carlos Ernesto Garrido
Speciali, Jose Geraldo
Santos, Antonio Carlos
author_role author
author2 Diniz, Paula Rejane Beserra
Formigheri, Paulo
Salmon, Carlos Ernesto Garrido
Speciali, Jose Geraldo
Santos, Antonio Carlos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Foss, Maria Paula
Diniz, Paula Rejane Beserra
Formigheri, Paulo
Salmon, Carlos Ernesto Garrido
Speciali, Jose Geraldo
Santos, Antonio Carlos
description OBJECTIVE: To understand the relationships between brain structures and function (behavior and cognition) in healthy aging. METHOD: The study group was composed of 56 healthy elderly subjects who underwent neuropsychological assessment and quantitative magnetic resonance imaging. Cluster analysis classified the cohort into two groups, one (cluster 1) in which the magnetic resonance imaging metrics were more preserved (mean age: 66.4 years) and another (cluster 2) with less preserved markers of healthy brain tissue (mean age: 75.4 years). RESULTS: The subjects in cluster 2 (older group) had worse indices of interference in the Stroop test compared with the subjects in cluster 1 (younger group). Therefore, a simple test such as the Stroop test could differentiate groups of younger and older subjects based on magnetic resonance imaging metrics. CONCLUSION: These results are in agreement with the inhibitory control hypotheses regarding cognitive aging and may also be important in the interpretation of studies with other clinical groups, such as patients with dementia and mild cognitive impairment.
publishDate 2013
dc.date.none.fl_str_mv 2013-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/76988
10.1590/clin.v68i9.76988
url https://www.revistas.usp.br/clinics/article/view/76988
identifier_str_mv 10.1590/clin.v68i9.76988
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/76988/80849
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 68 No. 9 (2013); 1197-1205
Clinics; v. 68 n. 9 (2013); 1197-1205
Clinics; Vol. 68 Núm. 9 (2013); 1197-1205
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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