Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma

Detalhes bibliográficos
Autor(a) principal: Bispo Júnior, Rosalvo Zósimo
Data de Publicação: 2008
Outros Autores: Camargo, Olavo Pires de, Oliveira, Cláudia Regina G. C. M. de, Filippi, Renée Zon, Baptista, André Mathias, Caiero, Marcelo Tadeu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/17846
Resumo: OBJECTIVE: The objective of this study was to investigate MDM2 (murine double minute 2) protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival and overall survival in patients with primary liposarcomas of the extremities. MATERIALS AND METHODS: Of 50 patients with primary liposarcomas of the extremities admitted to a Reference Service, between 1968 and 2004, 25 were enrolled in the study, following eligibility and exclusion criteria. RESULTS: The adverse factors that influenced the risk for local recurrence in the univariant analysis included male sex (P = 0.023), pleomorphic histological subtype (P = 0.027), and high histological grade (P = 0.007). Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis. Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003). CONCLUSIONS: There was no correlation between immunohistochemically observed MDM2 protein expressions and the anatomical and pathological variables studied. The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival). The immunoexpression of MDM2 protein was a frequent event in the different subtypes of liposarcomas.
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spelling Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma ImmunohistochemistryProto-oncogenic proteinsPrognosisLiposarcoma^i1^spatholLiposarcoma^i1^ssurg OBJECTIVE: The objective of this study was to investigate MDM2 (murine double minute 2) protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival and overall survival in patients with primary liposarcomas of the extremities. MATERIALS AND METHODS: Of 50 patients with primary liposarcomas of the extremities admitted to a Reference Service, between 1968 and 2004, 25 were enrolled in the study, following eligibility and exclusion criteria. RESULTS: The adverse factors that influenced the risk for local recurrence in the univariant analysis included male sex (P = 0.023), pleomorphic histological subtype (P = 0.027), and high histological grade (P = 0.007). Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis. Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003). CONCLUSIONS: There was no correlation between immunohistochemically observed MDM2 protein expressions and the anatomical and pathological variables studied. The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival). The immunoexpression of MDM2 protein was a frequent event in the different subtypes of liposarcomas. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1784610.1590/S1807-59322008000200002Clinics; Vol. 63 No. 2 (2008); 157-164 Clinics; v. 63 n. 2 (2008); 157-164 Clinics; Vol. 63 Núm. 2 (2008); 157-164 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17846/19911Bispo Júnior, Rosalvo ZósimoCamargo, Olavo Pires deOliveira, Cláudia Regina G. C. M. deFilippi, Renée ZonBaptista, André MathiasCaiero, Marcelo Tadeuinfo:eu-repo/semantics/openAccess2012-05-22T18:37:41Zoai:revistas.usp.br:article/17846Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:37:41Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma
title Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma
spellingShingle Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma
Bispo Júnior, Rosalvo Zósimo
Immunohistochemistry
Proto-oncogenic proteins
Prognosis
Liposarcoma^i1^spathol
Liposarcoma^i1^ssurg
title_short Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma
title_full Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma
title_fullStr Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma
title_full_unstemmed Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma
title_sort Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma
author Bispo Júnior, Rosalvo Zósimo
author_facet Bispo Júnior, Rosalvo Zósimo
Camargo, Olavo Pires de
Oliveira, Cláudia Regina G. C. M. de
Filippi, Renée Zon
Baptista, André Mathias
Caiero, Marcelo Tadeu
author_role author
author2 Camargo, Olavo Pires de
Oliveira, Cláudia Regina G. C. M. de
Filippi, Renée Zon
Baptista, André Mathias
Caiero, Marcelo Tadeu
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bispo Júnior, Rosalvo Zósimo
Camargo, Olavo Pires de
Oliveira, Cláudia Regina G. C. M. de
Filippi, Renée Zon
Baptista, André Mathias
Caiero, Marcelo Tadeu
dc.subject.por.fl_str_mv Immunohistochemistry
Proto-oncogenic proteins
Prognosis
Liposarcoma^i1^spathol
Liposarcoma^i1^ssurg
topic Immunohistochemistry
Proto-oncogenic proteins
Prognosis
Liposarcoma^i1^spathol
Liposarcoma^i1^ssurg
description OBJECTIVE: The objective of this study was to investigate MDM2 (murine double minute 2) protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival and overall survival in patients with primary liposarcomas of the extremities. MATERIALS AND METHODS: Of 50 patients with primary liposarcomas of the extremities admitted to a Reference Service, between 1968 and 2004, 25 were enrolled in the study, following eligibility and exclusion criteria. RESULTS: The adverse factors that influenced the risk for local recurrence in the univariant analysis included male sex (P = 0.023), pleomorphic histological subtype (P = 0.027), and high histological grade (P = 0.007). Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis. Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003). CONCLUSIONS: There was no correlation between immunohistochemically observed MDM2 protein expressions and the anatomical and pathological variables studied. The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival). The immunoexpression of MDM2 protein was a frequent event in the different subtypes of liposarcomas.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17846
10.1590/S1807-59322008000200002
url https://www.revistas.usp.br/clinics/article/view/17846
identifier_str_mv 10.1590/S1807-59322008000200002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17846/19911
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 63 No. 2 (2008); 157-164
Clinics; v. 63 n. 2 (2008); 157-164
Clinics; Vol. 63 Núm. 2 (2008); 157-164
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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