Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/17846 |
Resumo: | OBJECTIVE: The objective of this study was to investigate MDM2 (murine double minute 2) protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival and overall survival in patients with primary liposarcomas of the extremities. MATERIALS AND METHODS: Of 50 patients with primary liposarcomas of the extremities admitted to a Reference Service, between 1968 and 2004, 25 were enrolled in the study, following eligibility and exclusion criteria. RESULTS: The adverse factors that influenced the risk for local recurrence in the univariant analysis included male sex (P = 0.023), pleomorphic histological subtype (P = 0.027), and high histological grade (P = 0.007). Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis. Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003). CONCLUSIONS: There was no correlation between immunohistochemically observed MDM2 protein expressions and the anatomical and pathological variables studied. The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival). The immunoexpression of MDM2 protein was a frequent event in the different subtypes of liposarcomas. |
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Clinics |
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Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma ImmunohistochemistryProto-oncogenic proteinsPrognosisLiposarcoma^i1^spatholLiposarcoma^i1^ssurg OBJECTIVE: The objective of this study was to investigate MDM2 (murine double minute 2) protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival and overall survival in patients with primary liposarcomas of the extremities. MATERIALS AND METHODS: Of 50 patients with primary liposarcomas of the extremities admitted to a Reference Service, between 1968 and 2004, 25 were enrolled in the study, following eligibility and exclusion criteria. RESULTS: The adverse factors that influenced the risk for local recurrence in the univariant analysis included male sex (P = 0.023), pleomorphic histological subtype (P = 0.027), and high histological grade (P = 0.007). Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis. Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003). CONCLUSIONS: There was no correlation between immunohistochemically observed MDM2 protein expressions and the anatomical and pathological variables studied. The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival). The immunoexpression of MDM2 protein was a frequent event in the different subtypes of liposarcomas. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1784610.1590/S1807-59322008000200002Clinics; Vol. 63 No. 2 (2008); 157-164 Clinics; v. 63 n. 2 (2008); 157-164 Clinics; Vol. 63 Núm. 2 (2008); 157-164 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17846/19911Bispo Júnior, Rosalvo ZósimoCamargo, Olavo Pires deOliveira, Cláudia Regina G. C. M. deFilippi, Renée ZonBaptista, André MathiasCaiero, Marcelo Tadeuinfo:eu-repo/semantics/openAccess2012-05-22T18:37:41Zoai:revistas.usp.br:article/17846Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:37:41Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma |
title |
Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma |
spellingShingle |
Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma Bispo Júnior, Rosalvo Zósimo Immunohistochemistry Proto-oncogenic proteins Prognosis Liposarcoma^i1^spathol Liposarcoma^i1^ssurg |
title_short |
Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma |
title_full |
Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma |
title_fullStr |
Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma |
title_full_unstemmed |
Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma |
title_sort |
Prognostic factors and expression of MDM2 in patients with primary extremity liposarcoma |
author |
Bispo Júnior, Rosalvo Zósimo |
author_facet |
Bispo Júnior, Rosalvo Zósimo Camargo, Olavo Pires de Oliveira, Cláudia Regina G. C. M. de Filippi, Renée Zon Baptista, André Mathias Caiero, Marcelo Tadeu |
author_role |
author |
author2 |
Camargo, Olavo Pires de Oliveira, Cláudia Regina G. C. M. de Filippi, Renée Zon Baptista, André Mathias Caiero, Marcelo Tadeu |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Bispo Júnior, Rosalvo Zósimo Camargo, Olavo Pires de Oliveira, Cláudia Regina G. C. M. de Filippi, Renée Zon Baptista, André Mathias Caiero, Marcelo Tadeu |
dc.subject.por.fl_str_mv |
Immunohistochemistry Proto-oncogenic proteins Prognosis Liposarcoma^i1^spathol Liposarcoma^i1^ssurg |
topic |
Immunohistochemistry Proto-oncogenic proteins Prognosis Liposarcoma^i1^spathol Liposarcoma^i1^ssurg |
description |
OBJECTIVE: The objective of this study was to investigate MDM2 (murine double minute 2) protein expression and evaluate its relationship with some anatomical and pathological aspects, aiming also to identify prognostic factors concerning local recurrence-free survival, metastasis-free survival and overall survival in patients with primary liposarcomas of the extremities. MATERIALS AND METHODS: Of 50 patients with primary liposarcomas of the extremities admitted to a Reference Service, between 1968 and 2004, 25 were enrolled in the study, following eligibility and exclusion criteria. RESULTS: The adverse factors that influenced the risk for local recurrence in the univariant analysis included male sex (P = 0.023), pleomorphic histological subtype (P = 0.027), and high histological grade (P = 0.007). Concerning metastasis-free survival, age less than 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003) had a worse prognosis. Adverse factors for overall survival were age under 50 years (P = 0.040), male sex (P = 0.040), pleomorphic subtype (P < 0.001), and high histological grade (P = 0.003). CONCLUSIONS: There was no correlation between immunohistochemically observed MDM2 protein expressions and the anatomical and pathological variables studied. The immunohistochemical expression of MDM2 protein was not considered to have a prognostic value for any of the surviving patients in this study (local recurrence-free survival, metastasis-free survival, or overall survival). The immunoexpression of MDM2 protein was a frequent event in the different subtypes of liposarcomas. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/17846 10.1590/S1807-59322008000200002 |
url |
https://www.revistas.usp.br/clinics/article/view/17846 |
identifier_str_mv |
10.1590/S1807-59322008000200002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/17846/19911 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 63 No. 2 (2008); 157-164 Clinics; v. 63 n. 2 (2008); 157-164 Clinics; Vol. 63 Núm. 2 (2008); 157-164 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222753956036608 |