Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis

Detalhes bibliográficos
Autor(a) principal: Matos, Ricardo Tedeschi
Data de Publicação: 2009
Outros Autores: Honório, Rodrigo Schuler, Caldini, Elia Garcia, Hashimoto, Claudio Lyoiti, Ferreira, Marcelo Alves, Navarro-Rodriguez, Tomás
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/17892
Resumo: The purpose of this study was to compare esophageal infusion with 0.1 N hydrochloridric acid (HCl) to esophageal infusion with saline in patients presenting with typical gastroesophageal reflux symptoms and erosive esophagitis. METHODS: Upper gastrointestinal endoscopy was performed on 44 prospective subjects, 29 of whom were included in the study. Eighteen patients presented with normal esophagi (Control Group "C"), nine of whom were infused with HCl and nine with saline. Eleven patients presented with erosive esophagitis (Lesion Group "L"), five of whom were infused with HCl and six with saline. Biopsies of the esophageal mucosa were collected before and after infusions. RESULTS: No statistically significant difference was found between the two types of infusions in terms of the dilation of the intercellular space of the esophageal epithelium, regardless of the status of the patient. CONCLUSIONS: Response to HCl infusion cannot be used as a marker for gastroesophageal reflux disease.
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spelling Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis Gastroesophageal RefluxDilatedIntercellular SpaceEpitheliumEsophagus The purpose of this study was to compare esophageal infusion with 0.1 N hydrochloridric acid (HCl) to esophageal infusion with saline in patients presenting with typical gastroesophageal reflux symptoms and erosive esophagitis. METHODS: Upper gastrointestinal endoscopy was performed on 44 prospective subjects, 29 of whom were included in the study. Eighteen patients presented with normal esophagi (Control Group "C"), nine of whom were infused with HCl and nine with saline. Eleven patients presented with erosive esophagitis (Lesion Group "L"), five of whom were infused with HCl and six with saline. Biopsies of the esophageal mucosa were collected before and after infusions. RESULTS: No statistically significant difference was found between the two types of infusions in terms of the dilation of the intercellular space of the esophageal epithelium, regardless of the status of the patient. CONCLUSIONS: Response to HCl infusion cannot be used as a marker for gastroesophageal reflux disease. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1789210.1590/S1807-59322009000700011Clinics; Vol. 64 No. 7 (2009); 669-674 Clinics; v. 64 n. 7 (2009); 669-674 Clinics; Vol. 64 Núm. 7 (2009); 669-674 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17892/19957Matos, Ricardo TedeschiHonório, Rodrigo SchulerCaldini, Elia GarciaHashimoto, Claudio LyoitiFerreira, Marcelo AlvesNavarro-Rodriguez, Tomásinfo:eu-repo/semantics/openAccess2012-05-22T18:42:11Zoai:revistas.usp.br:article/17892Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:42:11Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis
title Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis
spellingShingle Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis
Matos, Ricardo Tedeschi
Gastroesophageal Reflux
Dilated
Intercellular Space
Epithelium
Esophagus
title_short Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis
title_full Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis
title_fullStr Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis
title_full_unstemmed Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis
title_sort Variation of the intercellular space in the esophageal epithelium in response to hydrochloridric acid infusion in patients with erosive esophagitis
author Matos, Ricardo Tedeschi
author_facet Matos, Ricardo Tedeschi
Honório, Rodrigo Schuler
Caldini, Elia Garcia
Hashimoto, Claudio Lyoiti
Ferreira, Marcelo Alves
Navarro-Rodriguez, Tomás
author_role author
author2 Honório, Rodrigo Schuler
Caldini, Elia Garcia
Hashimoto, Claudio Lyoiti
Ferreira, Marcelo Alves
Navarro-Rodriguez, Tomás
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Matos, Ricardo Tedeschi
Honório, Rodrigo Schuler
Caldini, Elia Garcia
Hashimoto, Claudio Lyoiti
Ferreira, Marcelo Alves
Navarro-Rodriguez, Tomás
dc.subject.por.fl_str_mv Gastroesophageal Reflux
Dilated
Intercellular Space
Epithelium
Esophagus
topic Gastroesophageal Reflux
Dilated
Intercellular Space
Epithelium
Esophagus
description The purpose of this study was to compare esophageal infusion with 0.1 N hydrochloridric acid (HCl) to esophageal infusion with saline in patients presenting with typical gastroesophageal reflux symptoms and erosive esophagitis. METHODS: Upper gastrointestinal endoscopy was performed on 44 prospective subjects, 29 of whom were included in the study. Eighteen patients presented with normal esophagi (Control Group "C"), nine of whom were infused with HCl and nine with saline. Eleven patients presented with erosive esophagitis (Lesion Group "L"), five of whom were infused with HCl and six with saline. Biopsies of the esophageal mucosa were collected before and after infusions. RESULTS: No statistically significant difference was found between the two types of infusions in terms of the dilation of the intercellular space of the esophageal epithelium, regardless of the status of the patient. CONCLUSIONS: Response to HCl infusion cannot be used as a marker for gastroesophageal reflux disease.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17892
10.1590/S1807-59322009000700011
url https://www.revistas.usp.br/clinics/article/view/17892
identifier_str_mv 10.1590/S1807-59322009000700011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/17892/19957
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 64 No. 7 (2009); 669-674
Clinics; v. 64 n. 7 (2009); 669-674
Clinics; Vol. 64 Núm. 7 (2009); 669-674
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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