Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats

• Autor(a) principal: Mostarda, Cristiano
• Data de Publicação: 2012
• Outros Autores: Moraes-Silva, Ivana Cinthya, Salemi, Vera Maria Cury, Machi, Jacqueline Freire, Rodrigues, Bruno, De Angelis, Kátia, Farah, Vera de Moura Azevedo, Irigoyen, Maria Claudia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Clinics
• Texto Completo: https://www.revistas.usp.br/clinics/article/view/40159
• topic: Metabolic Syndrome; Diastolic function; Exercise Training; Insulin resistance; Cardiac hypertrophy

OBJECTIVE: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. METHODS: Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at p