Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/17967 |
Resumo: | OBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress. METHOD: We used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of - 8ºC on the last day of the study. RESULTS: The MEM group had the largest cardiomyocyte nuclear size (151 ± 3.5 μm³ vs. CON: 142 ± 2.3 μm³; p |
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Clinics |
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Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress MemantineCardiac myocytesCardiotonic agentsCell nucleus structuresHeart OBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress. METHOD: We used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of - 8ºC on the last day of the study. RESULTS: The MEM group had the largest cardiomyocyte nuclear size (151 ± 3.5 μm³ vs. CON: 142 ± 2.3 μm³; pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1796710.1590/S1807-59322009000900014Clinics; Vol. 64 No. 9 (2009); 921-926 Clinics; v. 64 n. 9 (2009); 921-926 Clinics; Vol. 64 Núm. 9 (2009); 921-926 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17967/20032Meneghini, AdrianoFerreira, CelsoAbreu, Luiz Carlos deValenti, Vitor E.Ferreira, MarceloF. Filho, CelsoMurad, Neifinfo:eu-repo/semantics/openAccess2012-05-22T18:48:56Zoai:revistas.usp.br:article/17967Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:48:56Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
title |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
spellingShingle |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress Meneghini, Adriano Memantine Cardiac myocytes Cardiotonic agents Cell nucleus structures Heart |
title_short |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
title_full |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
title_fullStr |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
title_full_unstemmed |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
title_sort |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
author |
Meneghini, Adriano |
author_facet |
Meneghini, Adriano Ferreira, Celso Abreu, Luiz Carlos de Valenti, Vitor E. Ferreira, Marcelo F. Filho, Celso Murad, Neif |
author_role |
author |
author2 |
Ferreira, Celso Abreu, Luiz Carlos de Valenti, Vitor E. Ferreira, Marcelo F. Filho, Celso Murad, Neif |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Meneghini, Adriano Ferreira, Celso Abreu, Luiz Carlos de Valenti, Vitor E. Ferreira, Marcelo F. Filho, Celso Murad, Neif |
dc.subject.por.fl_str_mv |
Memantine Cardiac myocytes Cardiotonic agents Cell nucleus structures Heart |
topic |
Memantine Cardiac myocytes Cardiotonic agents Cell nucleus structures Heart |
description |
OBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress. METHOD: We used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of - 8ºC on the last day of the study. RESULTS: The MEM group had the largest cardiomyocyte nuclear size (151 ± 3.5 μm³ vs. CON: 142 ± 2.3 μm³; p |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/17967 10.1590/S1807-59322009000900014 |
url |
https://www.revistas.usp.br/clinics/article/view/17967 |
identifier_str_mv |
10.1590/S1807-59322009000900014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/17967/20032 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 64 No. 9 (2009); 921-926 Clinics; v. 64 n. 9 (2009); 921-926 Clinics; Vol. 64 Núm. 9 (2009); 921-926 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222754391195648 |