Survival and prognosis of young adults with gastric cancer

Detalhes bibliográficos
Autor(a) principal: Cormedi, Marina Candido Visontai
Data de Publicação: 2019
Outros Autores: Katayama, Maria Lucia Hirata, Guindalini, Rodrigo Santa Cruz, Faraj, Sheila Friedrich, Folgueira, Maria Aparecida Azevedo Koike
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/154742
Resumo: OBJECTIVES: Survival data for young adults (YA) with gastric cancer is conflicting and scarce in Brazil. The aim of this study was to compare the clinicopathological factors and survival rates of younger and older patients with gastric cancer. METHODS: Hospital registries for 294 gastric cancer patients from a reference cancer hospital in Sa˜o Paulo, Brazil, were consulted for the retrieval of clinicopathological information and follow-up time. Patients were placed into the following groups: YA (p40 years; N=71), older adult (OA: 41 to 65 years; N=129) and elderly (E: X66 years; N=94). Differences were assessed through Pearson’s w2 test, Kaplan-Meier analysis, Log rank test and Cox regression. RESULTS: More YA were diagnosed with advanced disease (clinical stage III/IV: 86.7% YA, 69.9% OA, and 67% E); however, fewer E patients underwent surgery (64.3% YA, 72.7% OA, and 52.4% E). The median overall survival among all patients was 16 months, and the overall survival rate was not significantly different among the age groups (p=0.129). There were no significant differences in the disease-free survival rate. Metastatic disease at diagnosis (HR=4.84; po0.01) was associated with an increased hazard of death for YA. CONCLUSION: Overall survival was similar among age groups. Metastatic disease at diagnosis was the only factor associated with a poorer prognosis in YA. These results suggest that younger patients deserve special attention regarding the detection of early stage disease.
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spelling Survival and prognosis of young adults with gastric cancerStomach NeoplasmsSurvivalYoung AdultOBJECTIVES: Survival data for young adults (YA) with gastric cancer is conflicting and scarce in Brazil. The aim of this study was to compare the clinicopathological factors and survival rates of younger and older patients with gastric cancer. METHODS: Hospital registries for 294 gastric cancer patients from a reference cancer hospital in Sa˜o Paulo, Brazil, were consulted for the retrieval of clinicopathological information and follow-up time. Patients were placed into the following groups: YA (p40 years; N=71), older adult (OA: 41 to 65 years; N=129) and elderly (E: X66 years; N=94). Differences were assessed through Pearson’s w2 test, Kaplan-Meier analysis, Log rank test and Cox regression. RESULTS: More YA were diagnosed with advanced disease (clinical stage III/IV: 86.7% YA, 69.9% OA, and 67% E); however, fewer E patients underwent surgery (64.3% YA, 72.7% OA, and 52.4% E). The median overall survival among all patients was 16 months, and the overall survival rate was not significantly different among the age groups (p=0.129). There were no significant differences in the disease-free survival rate. Metastatic disease at diagnosis (HR=4.84; po0.01) was associated with an increased hazard of death for YA. CONCLUSION: Overall survival was similar among age groups. Metastatic disease at diagnosis was the only factor associated with a poorer prognosis in YA. These results suggest that younger patients deserve special attention regarding the detection of early stage disease.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-02-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/15474210.6061/clinics/2018/e651sClinics; Vol. 73 No. Suppl. 1 (2018); e651sClinics; v. 73 n. Suppl. 1 (2018); e651sClinics; Vol. 73 Núm. Suppl. 1 (2018); e651s1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/154742/150774Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessCormedi, Marina Candido VisontaiKatayama, Maria Lucia HirataGuindalini, Rodrigo Santa CruzFaraj, Sheila FriedrichFolgueira, Maria Aparecida Azevedo Koike2019-05-14T11:48:25Zoai:revistas.usp.br:article/154742Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-05-14T11:48:25Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Survival and prognosis of young adults with gastric cancer
title Survival and prognosis of young adults with gastric cancer
spellingShingle Survival and prognosis of young adults with gastric cancer
Cormedi, Marina Candido Visontai
Stomach Neoplasms
Survival
Young Adult
title_short Survival and prognosis of young adults with gastric cancer
title_full Survival and prognosis of young adults with gastric cancer
title_fullStr Survival and prognosis of young adults with gastric cancer
title_full_unstemmed Survival and prognosis of young adults with gastric cancer
title_sort Survival and prognosis of young adults with gastric cancer
author Cormedi, Marina Candido Visontai
author_facet Cormedi, Marina Candido Visontai
Katayama, Maria Lucia Hirata
Guindalini, Rodrigo Santa Cruz
Faraj, Sheila Friedrich
Folgueira, Maria Aparecida Azevedo Koike
author_role author
author2 Katayama, Maria Lucia Hirata
Guindalini, Rodrigo Santa Cruz
Faraj, Sheila Friedrich
Folgueira, Maria Aparecida Azevedo Koike
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cormedi, Marina Candido Visontai
Katayama, Maria Lucia Hirata
Guindalini, Rodrigo Santa Cruz
Faraj, Sheila Friedrich
Folgueira, Maria Aparecida Azevedo Koike
dc.subject.por.fl_str_mv Stomach Neoplasms
Survival
Young Adult
topic Stomach Neoplasms
Survival
Young Adult
description OBJECTIVES: Survival data for young adults (YA) with gastric cancer is conflicting and scarce in Brazil. The aim of this study was to compare the clinicopathological factors and survival rates of younger and older patients with gastric cancer. METHODS: Hospital registries for 294 gastric cancer patients from a reference cancer hospital in Sa˜o Paulo, Brazil, were consulted for the retrieval of clinicopathological information and follow-up time. Patients were placed into the following groups: YA (p40 years; N=71), older adult (OA: 41 to 65 years; N=129) and elderly (E: X66 years; N=94). Differences were assessed through Pearson’s w2 test, Kaplan-Meier analysis, Log rank test and Cox regression. RESULTS: More YA were diagnosed with advanced disease (clinical stage III/IV: 86.7% YA, 69.9% OA, and 67% E); however, fewer E patients underwent surgery (64.3% YA, 72.7% OA, and 52.4% E). The median overall survival among all patients was 16 months, and the overall survival rate was not significantly different among the age groups (p=0.129). There were no significant differences in the disease-free survival rate. Metastatic disease at diagnosis (HR=4.84; po0.01) was associated with an increased hazard of death for YA. CONCLUSION: Overall survival was similar among age groups. Metastatic disease at diagnosis was the only factor associated with a poorer prognosis in YA. These results suggest that younger patients deserve special attention regarding the detection of early stage disease.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-14
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/154742
10.6061/clinics/2018/e651s
url https://www.revistas.usp.br/clinics/article/view/154742
identifier_str_mv 10.6061/clinics/2018/e651s
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/154742/150774
dc.rights.driver.fl_str_mv Copyright (c) 2019 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 73 No. Suppl. 1 (2018); e651s
Clinics; v. 73 n. Suppl. 1 (2018); e651s
Clinics; Vol. 73 Núm. Suppl. 1 (2018); e651s
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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