Survival and prognosis of young adults with gastric cancer
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/154742 |
Resumo: | OBJECTIVES: Survival data for young adults (YA) with gastric cancer is conflicting and scarce in Brazil. The aim of this study was to compare the clinicopathological factors and survival rates of younger and older patients with gastric cancer. METHODS: Hospital registries for 294 gastric cancer patients from a reference cancer hospital in Sa˜o Paulo, Brazil, were consulted for the retrieval of clinicopathological information and follow-up time. Patients were placed into the following groups: YA (p40 years; N=71), older adult (OA: 41 to 65 years; N=129) and elderly (E: X66 years; N=94). Differences were assessed through Pearson’s w2 test, Kaplan-Meier analysis, Log rank test and Cox regression. RESULTS: More YA were diagnosed with advanced disease (clinical stage III/IV: 86.7% YA, 69.9% OA, and 67% E); however, fewer E patients underwent surgery (64.3% YA, 72.7% OA, and 52.4% E). The median overall survival among all patients was 16 months, and the overall survival rate was not significantly different among the age groups (p=0.129). There were no significant differences in the disease-free survival rate. Metastatic disease at diagnosis (HR=4.84; po0.01) was associated with an increased hazard of death for YA. CONCLUSION: Overall survival was similar among age groups. Metastatic disease at diagnosis was the only factor associated with a poorer prognosis in YA. These results suggest that younger patients deserve special attention regarding the detection of early stage disease. |
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Clinics |
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Survival and prognosis of young adults with gastric cancerStomach NeoplasmsSurvivalYoung AdultOBJECTIVES: Survival data for young adults (YA) with gastric cancer is conflicting and scarce in Brazil. The aim of this study was to compare the clinicopathological factors and survival rates of younger and older patients with gastric cancer. METHODS: Hospital registries for 294 gastric cancer patients from a reference cancer hospital in Sa˜o Paulo, Brazil, were consulted for the retrieval of clinicopathological information and follow-up time. Patients were placed into the following groups: YA (p40 years; N=71), older adult (OA: 41 to 65 years; N=129) and elderly (E: X66 years; N=94). Differences were assessed through Pearson’s w2 test, Kaplan-Meier analysis, Log rank test and Cox regression. RESULTS: More YA were diagnosed with advanced disease (clinical stage III/IV: 86.7% YA, 69.9% OA, and 67% E); however, fewer E patients underwent surgery (64.3% YA, 72.7% OA, and 52.4% E). The median overall survival among all patients was 16 months, and the overall survival rate was not significantly different among the age groups (p=0.129). There were no significant differences in the disease-free survival rate. Metastatic disease at diagnosis (HR=4.84; po0.01) was associated with an increased hazard of death for YA. CONCLUSION: Overall survival was similar among age groups. Metastatic disease at diagnosis was the only factor associated with a poorer prognosis in YA. These results suggest that younger patients deserve special attention regarding the detection of early stage disease.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-02-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/15474210.6061/clinics/2018/e651sClinics; Vol. 73 No. Suppl. 1 (2018); e651sClinics; v. 73 n. Suppl. 1 (2018); e651sClinics; Vol. 73 Núm. Suppl. 1 (2018); e651s1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/154742/150774Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessCormedi, Marina Candido VisontaiKatayama, Maria Lucia HirataGuindalini, Rodrigo Santa CruzFaraj, Sheila FriedrichFolgueira, Maria Aparecida Azevedo Koike2019-05-14T11:48:25Zoai:revistas.usp.br:article/154742Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-05-14T11:48:25Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Survival and prognosis of young adults with gastric cancer |
title |
Survival and prognosis of young adults with gastric cancer |
spellingShingle |
Survival and prognosis of young adults with gastric cancer Cormedi, Marina Candido Visontai Stomach Neoplasms Survival Young Adult |
title_short |
Survival and prognosis of young adults with gastric cancer |
title_full |
Survival and prognosis of young adults with gastric cancer |
title_fullStr |
Survival and prognosis of young adults with gastric cancer |
title_full_unstemmed |
Survival and prognosis of young adults with gastric cancer |
title_sort |
Survival and prognosis of young adults with gastric cancer |
author |
Cormedi, Marina Candido Visontai |
author_facet |
Cormedi, Marina Candido Visontai Katayama, Maria Lucia Hirata Guindalini, Rodrigo Santa Cruz Faraj, Sheila Friedrich Folgueira, Maria Aparecida Azevedo Koike |
author_role |
author |
author2 |
Katayama, Maria Lucia Hirata Guindalini, Rodrigo Santa Cruz Faraj, Sheila Friedrich Folgueira, Maria Aparecida Azevedo Koike |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Cormedi, Marina Candido Visontai Katayama, Maria Lucia Hirata Guindalini, Rodrigo Santa Cruz Faraj, Sheila Friedrich Folgueira, Maria Aparecida Azevedo Koike |
dc.subject.por.fl_str_mv |
Stomach Neoplasms Survival Young Adult |
topic |
Stomach Neoplasms Survival Young Adult |
description |
OBJECTIVES: Survival data for young adults (YA) with gastric cancer is conflicting and scarce in Brazil. The aim of this study was to compare the clinicopathological factors and survival rates of younger and older patients with gastric cancer. METHODS: Hospital registries for 294 gastric cancer patients from a reference cancer hospital in Sa˜o Paulo, Brazil, were consulted for the retrieval of clinicopathological information and follow-up time. Patients were placed into the following groups: YA (p40 years; N=71), older adult (OA: 41 to 65 years; N=129) and elderly (E: X66 years; N=94). Differences were assessed through Pearson’s w2 test, Kaplan-Meier analysis, Log rank test and Cox regression. RESULTS: More YA were diagnosed with advanced disease (clinical stage III/IV: 86.7% YA, 69.9% OA, and 67% E); however, fewer E patients underwent surgery (64.3% YA, 72.7% OA, and 52.4% E). The median overall survival among all patients was 16 months, and the overall survival rate was not significantly different among the age groups (p=0.129). There were no significant differences in the disease-free survival rate. Metastatic disease at diagnosis (HR=4.84; po0.01) was associated with an increased hazard of death for YA. CONCLUSION: Overall survival was similar among age groups. Metastatic disease at diagnosis was the only factor associated with a poorer prognosis in YA. These results suggest that younger patients deserve special attention regarding the detection of early stage disease. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/154742 10.6061/clinics/2018/e651s |
url |
https://www.revistas.usp.br/clinics/article/view/154742 |
identifier_str_mv |
10.6061/clinics/2018/e651s |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/154742/150774 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 73 No. Suppl. 1 (2018); e651s Clinics; v. 73 n. Suppl. 1 (2018); e651s Clinics; Vol. 73 Núm. Suppl. 1 (2018); e651s 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222763741347840 |