Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice

Detalhes bibliográficos
Autor(a) principal: Hajhashemi, Valiollah
Data de Publicação: 2010
Outros Autores: Rabbani, Mohammad, Ghanadi, Alireza, Davari, Elahe
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/18528
Resumo: INTRODUCTION: We investigated the antianxiety and sedative effects of the essential oil of Ducrosia anethifolia. Boiss. (Apiaceae). METHODS: We used elevated plus maze, spontaneous motor activity and ketamine-induced sleep tests in mice. In addition, the essential oil was analyzed by GC/MS. Twenty compounds were identified, and n-decanal (70.1%) and alpha-pinene (12.4%) constituted the major components. RESULTS: In elevated plus maze, Ducrosia anethifolia essential oil at doses of 25-200 mg/kg increased the percentage of open arm time and entries. Unlike diazepam, ducrosia anethifolia essential oil could not suppress spontaneous motor activity and did not alter ketamine-induced sleep parameters. These results are indicative of antianxiety effect of Ducrosia anethifolia essential oil without sedative effect
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spelling Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice Apiaceaediazepamelevated plus-mazeketaminespontaneous motor activity INTRODUCTION: We investigated the antianxiety and sedative effects of the essential oil of Ducrosia anethifolia. Boiss. (Apiaceae). METHODS: We used elevated plus maze, spontaneous motor activity and ketamine-induced sleep tests in mice. In addition, the essential oil was analyzed by GC/MS. Twenty compounds were identified, and n-decanal (70.1%) and alpha-pinene (12.4%) constituted the major components. RESULTS: In elevated plus maze, Ducrosia anethifolia essential oil at doses of 25-200 mg/kg increased the percentage of open arm time and entries. Unlike diazepam, ducrosia anethifolia essential oil could not suppress spontaneous motor activity and did not alter ketamine-induced sleep parameters. These results are indicative of antianxiety effect of Ducrosia anethifolia essential oil without sedative effect Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1852810.1590/S1807-59322010001000020Clinics; Vol. 65 No. 10 (2010); 1037-1042 Clinics; v. 65 n. 10 (2010); 1037-1042 Clinics; Vol. 65 Núm. 10 (2010); 1037-1042 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18528/20591Hajhashemi, ValiollahRabbani, MohammadGhanadi, AlirezaDavari, Elaheinfo:eu-repo/semantics/openAccess2012-05-23T11:30:16Zoai:revistas.usp.br:article/18528Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:30:16Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
title Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
spellingShingle Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
Hajhashemi, Valiollah
Apiaceae
diazepam
elevated plus-maze
ketamine
spontaneous motor activity
title_short Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
title_full Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
title_fullStr Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
title_full_unstemmed Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
title_sort Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
author Hajhashemi, Valiollah
author_facet Hajhashemi, Valiollah
Rabbani, Mohammad
Ghanadi, Alireza
Davari, Elahe
author_role author
author2 Rabbani, Mohammad
Ghanadi, Alireza
Davari, Elahe
author2_role author
author
author
dc.contributor.author.fl_str_mv Hajhashemi, Valiollah
Rabbani, Mohammad
Ghanadi, Alireza
Davari, Elahe
dc.subject.por.fl_str_mv Apiaceae
diazepam
elevated plus-maze
ketamine
spontaneous motor activity
topic Apiaceae
diazepam
elevated plus-maze
ketamine
spontaneous motor activity
description INTRODUCTION: We investigated the antianxiety and sedative effects of the essential oil of Ducrosia anethifolia. Boiss. (Apiaceae). METHODS: We used elevated plus maze, spontaneous motor activity and ketamine-induced sleep tests in mice. In addition, the essential oil was analyzed by GC/MS. Twenty compounds were identified, and n-decanal (70.1%) and alpha-pinene (12.4%) constituted the major components. RESULTS: In elevated plus maze, Ducrosia anethifolia essential oil at doses of 25-200 mg/kg increased the percentage of open arm time and entries. Unlike diazepam, ducrosia anethifolia essential oil could not suppress spontaneous motor activity and did not alter ketamine-induced sleep parameters. These results are indicative of antianxiety effect of Ducrosia anethifolia essential oil without sedative effect
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18528
10.1590/S1807-59322010001000020
url https://www.revistas.usp.br/clinics/article/view/18528
identifier_str_mv 10.1590/S1807-59322010001000020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18528/20591
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 65 No. 10 (2010); 1037-1042
Clinics; v. 65 n. 10 (2010); 1037-1042
Clinics; Vol. 65 Núm. 10 (2010); 1037-1042
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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