Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer

Detalhes bibliográficos
Autor(a) principal: Cunha, Lucas Leite
Data de Publicação: 2011
Outros Autores: Tincani, Alfio Jose, Assumpção, Ligia Vera Montalli da, Soares, Fernando Augusto, Vassallo, José, Ward, Laura Sterian
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/19362
Resumo: OBJECTIVES: The aim of this study was to investigate the role of the interleukin-18 +105A/C and interleukin-10 -1082A/G germline polymorphisms in the development and outcome of differentiated thyroid carcinoma associated or not with concurrent thyroiditis. METHODS: We studied 346 patients with differentiated thyroid carcinomas, comprising 292 papillary carcinomas and 54 follicular carcinomas, who were followed up for 12-298 months (mean 76.10 ± 68.23 months) according to a standard protocol. We genotyped 200 patients and 144 control individuals for the interleukin-18 +105A/C polymorphism, and we genotyped 183 patients and 137 controls for the interleukin-10 -1082A/G polymorphism. RESULTS: Interleukin-18 polymorphisms were not associated with chronic lymphocytic thyroiditis or any clinical or pathological feature of tumor aggressiveness. However, there was an association between the presence of interleukin-10 variants and chronic lymphocytic thyroiditis. Chronic lymphocytic thyroiditis was present in 21.74% of differentiated thyroid carcinoma patients, most frequently affecting women previously diagnosed with Hashimoto's thyroiditis who had received a lower 131I cumulative dose and did not present lymph node metastases. CONCLUSIONS: We conclude that the inheritance of a G allele at the interleukin-10 -1082A/G polymorphism may favor a concurrent thyroid autoimmunity in differentiated thyroid carcinoma patients, and this autoimmunity may favor a better prognosis for these patients.
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spelling Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer Tumor immunityInterleukin-10Interleukin-18Chronic lymphocytic thyroiditisImmunogenetics OBJECTIVES: The aim of this study was to investigate the role of the interleukin-18 +105A/C and interleukin-10 -1082A/G germline polymorphisms in the development and outcome of differentiated thyroid carcinoma associated or not with concurrent thyroiditis. METHODS: We studied 346 patients with differentiated thyroid carcinomas, comprising 292 papillary carcinomas and 54 follicular carcinomas, who were followed up for 12-298 months (mean 76.10 ± 68.23 months) according to a standard protocol. We genotyped 200 patients and 144 control individuals for the interleukin-18 +105A/C polymorphism, and we genotyped 183 patients and 137 controls for the interleukin-10 -1082A/G polymorphism. RESULTS: Interleukin-18 polymorphisms were not associated with chronic lymphocytic thyroiditis or any clinical or pathological feature of tumor aggressiveness. However, there was an association between the presence of interleukin-10 variants and chronic lymphocytic thyroiditis. Chronic lymphocytic thyroiditis was present in 21.74% of differentiated thyroid carcinoma patients, most frequently affecting women previously diagnosed with Hashimoto's thyroiditis who had received a lower 131I cumulative dose and did not present lymph node metastases. CONCLUSIONS: We conclude that the inheritance of a G allele at the interleukin-10 -1082A/G polymorphism may favor a concurrent thyroid autoimmunity in differentiated thyroid carcinoma patients, and this autoimmunity may favor a better prognosis for these patients. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1936210.1590/S1807-59322011000700014Clinics; Vol. 66 No. 7 (2011); 1203-1208 Clinics; v. 66 n. 7 (2011); 1203-1208 Clinics; Vol. 66 Núm. 7 (2011); 1203-1208 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19362/21425Cunha, Lucas LeiteTincani, Alfio JoseAssumpção, Ligia Vera Montalli daSoares, Fernando AugustoVassallo, JoséWard, Laura Sterianinfo:eu-repo/semantics/openAccess2012-05-23T16:36:17Zoai:revistas.usp.br:article/19362Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:36:17Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer
title Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer
spellingShingle Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer
Cunha, Lucas Leite
Tumor immunity
Interleukin-10
Interleukin-18
Chronic lymphocytic thyroiditis
Immunogenetics
title_short Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer
title_full Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer
title_fullStr Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer
title_full_unstemmed Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer
title_sort Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer
author Cunha, Lucas Leite
author_facet Cunha, Lucas Leite
Tincani, Alfio Jose
Assumpção, Ligia Vera Montalli da
Soares, Fernando Augusto
Vassallo, José
Ward, Laura Sterian
author_role author
author2 Tincani, Alfio Jose
Assumpção, Ligia Vera Montalli da
Soares, Fernando Augusto
Vassallo, José
Ward, Laura Sterian
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cunha, Lucas Leite
Tincani, Alfio Jose
Assumpção, Ligia Vera Montalli da
Soares, Fernando Augusto
Vassallo, José
Ward, Laura Sterian
dc.subject.por.fl_str_mv Tumor immunity
Interleukin-10
Interleukin-18
Chronic lymphocytic thyroiditis
Immunogenetics
topic Tumor immunity
Interleukin-10
Interleukin-18
Chronic lymphocytic thyroiditis
Immunogenetics
description OBJECTIVES: The aim of this study was to investigate the role of the interleukin-18 +105A/C and interleukin-10 -1082A/G germline polymorphisms in the development and outcome of differentiated thyroid carcinoma associated or not with concurrent thyroiditis. METHODS: We studied 346 patients with differentiated thyroid carcinomas, comprising 292 papillary carcinomas and 54 follicular carcinomas, who were followed up for 12-298 months (mean 76.10 ± 68.23 months) according to a standard protocol. We genotyped 200 patients and 144 control individuals for the interleukin-18 +105A/C polymorphism, and we genotyped 183 patients and 137 controls for the interleukin-10 -1082A/G polymorphism. RESULTS: Interleukin-18 polymorphisms were not associated with chronic lymphocytic thyroiditis or any clinical or pathological feature of tumor aggressiveness. However, there was an association between the presence of interleukin-10 variants and chronic lymphocytic thyroiditis. Chronic lymphocytic thyroiditis was present in 21.74% of differentiated thyroid carcinoma patients, most frequently affecting women previously diagnosed with Hashimoto's thyroiditis who had received a lower 131I cumulative dose and did not present lymph node metastases. CONCLUSIONS: We conclude that the inheritance of a G allele at the interleukin-10 -1082A/G polymorphism may favor a concurrent thyroid autoimmunity in differentiated thyroid carcinoma patients, and this autoimmunity may favor a better prognosis for these patients.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19362
10.1590/S1807-59322011000700014
url https://www.revistas.usp.br/clinics/article/view/19362
identifier_str_mv 10.1590/S1807-59322011000700014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19362/21425
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 66 No. 7 (2011); 1203-1208
Clinics; v. 66 n. 7 (2011); 1203-1208
Clinics; Vol. 66 Núm. 7 (2011); 1203-1208
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
_version_ 1800222756828086272

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