Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension

Detalhes bibliográficos
Autor(a) principal: Fernandes, Caio Julio Cesar dos Santos
Data de Publicação: 2020
Outros Autores: Oliveira, Ellen Pierre de, Salibe-Filho, Willian, Terra-Filho, Mario, Jardim, Carlos Vianna Poyares, Kato-Morinaga, Luciana Tamie, Hoette, Susana, Souza, Rogerio de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/167269
Resumo: OBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique form of pulmonary hypertension (PH) that arises from obstruction of the pulmonary vessels by recanalized thromboembolic material. CTEPH has a wide range of radiologic presentations. Commonly, it presents as main pulmonary artery enlargement, peripheral vascular obstructions, bronchial artery dilations, and mosaic attenuation patterns. Nevertheless, other uncommon presentations have been described, such as lung cavities. These lesions may be solely related to chronic lung parenchyma ischemia but may also be a consequence of concomitant chronic infectious conditions. The objective of this study was to evaluate the different etiologies that cause lung cavities in CTEPH patients. METHODS: A retrospective data analysis of the medical records of CTEPH patients in a single reference PH center that contained or mentioned lung cavities was conducted between 2013 and 2016. RESULTS: Seven CTEPH patients with lung cavities were identified. The cavities had different sizes, locations, and wall thicknesses. In two patients, the cavities were attributed to pulmonary infarction; in 5 patients, an infectious etiology was identified. CONCLUSION: Despite the possibility of being solely associated with chronic lung parenchyma ischemia, most cases of lung cavities in CTEPH patients were associated with chronic granulomatous diseases, reinforcing the need for active investigation of infectious agents in this setting.
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spelling Lung Cavities in Chronic Thromboembolic Pulmonary HypertensionChronic Thromboembolic Pulmonary HypertensionLung CavitiesPulmonary InfarctionChronic Granulomatous DiseasesInfectionOBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique form of pulmonary hypertension (PH) that arises from obstruction of the pulmonary vessels by recanalized thromboembolic material. CTEPH has a wide range of radiologic presentations. Commonly, it presents as main pulmonary artery enlargement, peripheral vascular obstructions, bronchial artery dilations, and mosaic attenuation patterns. Nevertheless, other uncommon presentations have been described, such as lung cavities. These lesions may be solely related to chronic lung parenchyma ischemia but may also be a consequence of concomitant chronic infectious conditions. The objective of this study was to evaluate the different etiologies that cause lung cavities in CTEPH patients. METHODS: A retrospective data analysis of the medical records of CTEPH patients in a single reference PH center that contained or mentioned lung cavities was conducted between 2013 and 2016. RESULTS: Seven CTEPH patients with lung cavities were identified. The cavities had different sizes, locations, and wall thicknesses. In two patients, the cavities were attributed to pulmonary infarction; in 5 patients, an infectious etiology was identified. CONCLUSION: Despite the possibility of being solely associated with chronic lung parenchyma ischemia, most cases of lung cavities in CTEPH patients were associated with chronic granulomatous diseases, reinforcing the need for active investigation of infectious agents in this setting.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2020-03-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/16726910.6061/clinics/2019/e1373Clinics; Vol. 75 (2020); e1373Clinics; v. 75 (2020); e1373Clinics; Vol. 75 (2020); e13731980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/167269/159696https://www.revistas.usp.br/clinics/article/view/167269/159697Copyright (c) 2020 Clinicsinfo:eu-repo/semantics/openAccessFernandes, Caio Julio Cesar dos SantosOliveira, Ellen Pierre deSalibe-Filho, WillianTerra-Filho, MarioJardim, Carlos Vianna PoyaresKato-Morinaga, Luciana TamieHoette, SusanaSouza, Rogerio de2020-03-02T17:22:36Zoai:revistas.usp.br:article/167269Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2020-03-02T17:22:36Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension
title Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension
spellingShingle Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension
Fernandes, Caio Julio Cesar dos Santos
Chronic Thromboembolic Pulmonary Hypertension
Lung Cavities
Pulmonary Infarction
Chronic Granulomatous Diseases
Infection
title_short Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension
title_full Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension
title_fullStr Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension
title_full_unstemmed Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension
title_sort Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension
author Fernandes, Caio Julio Cesar dos Santos
author_facet Fernandes, Caio Julio Cesar dos Santos
Oliveira, Ellen Pierre de
Salibe-Filho, Willian
Terra-Filho, Mario
Jardim, Carlos Vianna Poyares
Kato-Morinaga, Luciana Tamie
Hoette, Susana
Souza, Rogerio de
author_role author
author2 Oliveira, Ellen Pierre de
Salibe-Filho, Willian
Terra-Filho, Mario
Jardim, Carlos Vianna Poyares
Kato-Morinaga, Luciana Tamie
Hoette, Susana
Souza, Rogerio de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Caio Julio Cesar dos Santos
Oliveira, Ellen Pierre de
Salibe-Filho, Willian
Terra-Filho, Mario
Jardim, Carlos Vianna Poyares
Kato-Morinaga, Luciana Tamie
Hoette, Susana
Souza, Rogerio de
dc.subject.por.fl_str_mv Chronic Thromboembolic Pulmonary Hypertension
Lung Cavities
Pulmonary Infarction
Chronic Granulomatous Diseases
Infection
topic Chronic Thromboembolic Pulmonary Hypertension
Lung Cavities
Pulmonary Infarction
Chronic Granulomatous Diseases
Infection
description OBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique form of pulmonary hypertension (PH) that arises from obstruction of the pulmonary vessels by recanalized thromboembolic material. CTEPH has a wide range of radiologic presentations. Commonly, it presents as main pulmonary artery enlargement, peripheral vascular obstructions, bronchial artery dilations, and mosaic attenuation patterns. Nevertheless, other uncommon presentations have been described, such as lung cavities. These lesions may be solely related to chronic lung parenchyma ischemia but may also be a consequence of concomitant chronic infectious conditions. The objective of this study was to evaluate the different etiologies that cause lung cavities in CTEPH patients. METHODS: A retrospective data analysis of the medical records of CTEPH patients in a single reference PH center that contained or mentioned lung cavities was conducted between 2013 and 2016. RESULTS: Seven CTEPH patients with lung cavities were identified. The cavities had different sizes, locations, and wall thicknesses. In two patients, the cavities were attributed to pulmonary infarction; in 5 patients, an infectious etiology was identified. CONCLUSION: Despite the possibility of being solely associated with chronic lung parenchyma ischemia, most cases of lung cavities in CTEPH patients were associated with chronic granulomatous diseases, reinforcing the need for active investigation of infectious agents in this setting.
publishDate 2020
dc.date.none.fl_str_mv 2020-03-02
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/167269
10.6061/clinics/2019/e1373
url https://www.revistas.usp.br/clinics/article/view/167269
identifier_str_mv 10.6061/clinics/2019/e1373
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/167269/159696
https://www.revistas.usp.br/clinics/article/view/167269/159697
dc.rights.driver.fl_str_mv Copyright (c) 2020 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/xml
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 75 (2020); e1373
Clinics; v. 75 (2020); e1373
Clinics; Vol. 75 (2020); e1373
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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