Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/167269 |
Resumo: | OBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique form of pulmonary hypertension (PH) that arises from obstruction of the pulmonary vessels by recanalized thromboembolic material. CTEPH has a wide range of radiologic presentations. Commonly, it presents as main pulmonary artery enlargement, peripheral vascular obstructions, bronchial artery dilations, and mosaic attenuation patterns. Nevertheless, other uncommon presentations have been described, such as lung cavities. These lesions may be solely related to chronic lung parenchyma ischemia but may also be a consequence of concomitant chronic infectious conditions. The objective of this study was to evaluate the different etiologies that cause lung cavities in CTEPH patients. METHODS: A retrospective data analysis of the medical records of CTEPH patients in a single reference PH center that contained or mentioned lung cavities was conducted between 2013 and 2016. RESULTS: Seven CTEPH patients with lung cavities were identified. The cavities had different sizes, locations, and wall thicknesses. In two patients, the cavities were attributed to pulmonary infarction; in 5 patients, an infectious etiology was identified. CONCLUSION: Despite the possibility of being solely associated with chronic lung parenchyma ischemia, most cases of lung cavities in CTEPH patients were associated with chronic granulomatous diseases, reinforcing the need for active investigation of infectious agents in this setting. |
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Lung Cavities in Chronic Thromboembolic Pulmonary HypertensionChronic Thromboembolic Pulmonary HypertensionLung CavitiesPulmonary InfarctionChronic Granulomatous DiseasesInfectionOBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique form of pulmonary hypertension (PH) that arises from obstruction of the pulmonary vessels by recanalized thromboembolic material. CTEPH has a wide range of radiologic presentations. Commonly, it presents as main pulmonary artery enlargement, peripheral vascular obstructions, bronchial artery dilations, and mosaic attenuation patterns. Nevertheless, other uncommon presentations have been described, such as lung cavities. These lesions may be solely related to chronic lung parenchyma ischemia but may also be a consequence of concomitant chronic infectious conditions. The objective of this study was to evaluate the different etiologies that cause lung cavities in CTEPH patients. METHODS: A retrospective data analysis of the medical records of CTEPH patients in a single reference PH center that contained or mentioned lung cavities was conducted between 2013 and 2016. RESULTS: Seven CTEPH patients with lung cavities were identified. The cavities had different sizes, locations, and wall thicknesses. In two patients, the cavities were attributed to pulmonary infarction; in 5 patients, an infectious etiology was identified. CONCLUSION: Despite the possibility of being solely associated with chronic lung parenchyma ischemia, most cases of lung cavities in CTEPH patients were associated with chronic granulomatous diseases, reinforcing the need for active investigation of infectious agents in this setting.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2020-03-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/16726910.6061/clinics/2019/e1373Clinics; Vol. 75 (2020); e1373Clinics; v. 75 (2020); e1373Clinics; Vol. 75 (2020); e13731980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/167269/159696https://www.revistas.usp.br/clinics/article/view/167269/159697Copyright (c) 2020 Clinicsinfo:eu-repo/semantics/openAccessFernandes, Caio Julio Cesar dos SantosOliveira, Ellen Pierre deSalibe-Filho, WillianTerra-Filho, MarioJardim, Carlos Vianna PoyaresKato-Morinaga, Luciana TamieHoette, SusanaSouza, Rogerio de2020-03-02T17:22:36Zoai:revistas.usp.br:article/167269Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2020-03-02T17:22:36Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
title |
Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
spellingShingle |
Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension Fernandes, Caio Julio Cesar dos Santos Chronic Thromboembolic Pulmonary Hypertension Lung Cavities Pulmonary Infarction Chronic Granulomatous Diseases Infection |
title_short |
Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
title_full |
Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
title_fullStr |
Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
title_full_unstemmed |
Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
title_sort |
Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension |
author |
Fernandes, Caio Julio Cesar dos Santos |
author_facet |
Fernandes, Caio Julio Cesar dos Santos Oliveira, Ellen Pierre de Salibe-Filho, Willian Terra-Filho, Mario Jardim, Carlos Vianna Poyares Kato-Morinaga, Luciana Tamie Hoette, Susana Souza, Rogerio de |
author_role |
author |
author2 |
Oliveira, Ellen Pierre de Salibe-Filho, Willian Terra-Filho, Mario Jardim, Carlos Vianna Poyares Kato-Morinaga, Luciana Tamie Hoette, Susana Souza, Rogerio de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Fernandes, Caio Julio Cesar dos Santos Oliveira, Ellen Pierre de Salibe-Filho, Willian Terra-Filho, Mario Jardim, Carlos Vianna Poyares Kato-Morinaga, Luciana Tamie Hoette, Susana Souza, Rogerio de |
dc.subject.por.fl_str_mv |
Chronic Thromboembolic Pulmonary Hypertension Lung Cavities Pulmonary Infarction Chronic Granulomatous Diseases Infection |
topic |
Chronic Thromboembolic Pulmonary Hypertension Lung Cavities Pulmonary Infarction Chronic Granulomatous Diseases Infection |
description |
OBJECTIVES: Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique form of pulmonary hypertension (PH) that arises from obstruction of the pulmonary vessels by recanalized thromboembolic material. CTEPH has a wide range of radiologic presentations. Commonly, it presents as main pulmonary artery enlargement, peripheral vascular obstructions, bronchial artery dilations, and mosaic attenuation patterns. Nevertheless, other uncommon presentations have been described, such as lung cavities. These lesions may be solely related to chronic lung parenchyma ischemia but may also be a consequence of concomitant chronic infectious conditions. The objective of this study was to evaluate the different etiologies that cause lung cavities in CTEPH patients. METHODS: A retrospective data analysis of the medical records of CTEPH patients in a single reference PH center that contained or mentioned lung cavities was conducted between 2013 and 2016. RESULTS: Seven CTEPH patients with lung cavities were identified. The cavities had different sizes, locations, and wall thicknesses. In two patients, the cavities were attributed to pulmonary infarction; in 5 patients, an infectious etiology was identified. CONCLUSION: Despite the possibility of being solely associated with chronic lung parenchyma ischemia, most cases of lung cavities in CTEPH patients were associated with chronic granulomatous diseases, reinforcing the need for active investigation of infectious agents in this setting. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/167269 10.6061/clinics/2019/e1373 |
url |
https://www.revistas.usp.br/clinics/article/view/167269 |
identifier_str_mv |
10.6061/clinics/2019/e1373 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/167269/159696 https://www.revistas.usp.br/clinics/article/view/167269/159697 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 75 (2020); e1373 Clinics; v. 75 (2020); e1373 Clinics; Vol. 75 (2020); e1373 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222764704989184 |