Evaluation of the ERA antirabies vaccine against antigenic variants of rabies virus in different post-immunization periods

Detalhes bibliográficos
Autor(a) principal: Cordeiro, Cláudia C.
Data de Publicação: 1990
Outros Autores: Silva, Egon V., Miguel, Ornar, Germano, Pedro M. L.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/23780
Resumo: Protection levels of an attenuated antirabies vaccine, of ERA origin, prepared in Kidney tissue culture, were evaluated in mice. Two schemes of vaccination were utilized: a single dose and 6 doses on alternate days. Animals of different experimental groups were challenged at 15, 30, 60 and 120 days post-immunization with six antigenic variants of rabies virus: strains of dog origin (S. Paulo, Brazil and Nigéria), vampire origin (DR-19 and Pernambuco, Brazil), fox origin (Rio Grande do Norte,Brazil), and CVS (Challenge Virus Standard). The results showed the effectiveness of the ERA vaccine against all antigenic variants of street and sylvatic rabies virus, independently of the vaccination scheme. Against the laboratory strains (DR-19 and CVS) the ERA vaccine was less effective, mainly in the groups vaccinated with a single dose.
id USP-23_1c1f15c099064ae65310513762dbfa97
oai_identifier_str oai:revistas.usp.br:article/23780
network_acronym_str USP-23
network_name_str Revista de Saúde Pública
repository_id_str
spelling Evaluation of the ERA antirabies vaccine against antigenic variants of rabies virus in different post-immunization periods Avaliação da vacina anti-rábica ERA, frente a variantes antigênicas do vírus da raiva, em diferentes períodos pós-imunização Vacina antí-rábicaEficáciaRaiva^i1^sprevenRabies vaccineEfficacyRabies^i2^sprevention and cont Protection levels of an attenuated antirabies vaccine, of ERA origin, prepared in Kidney tissue culture, were evaluated in mice. Two schemes of vaccination were utilized: a single dose and 6 doses on alternate days. Animals of different experimental groups were challenged at 15, 30, 60 and 120 days post-immunization with six antigenic variants of rabies virus: strains of dog origin (S. Paulo, Brazil and Nigéria), vampire origin (DR-19 and Pernambuco, Brazil), fox origin (Rio Grande do Norte,Brazil), and CVS (Challenge Virus Standard). The results showed the effectiveness of the ERA vaccine against all antigenic variants of street and sylvatic rabies virus, independently of the vaccination scheme. Against the laboratory strains (DR-19 and CVS) the ERA vaccine was less effective, mainly in the groups vaccinated with a single dose. Avaliou-se, em camudongos, os níveis de proteção conferidos por uma vacina anti-rábica atenuada, preparada em cultura de tecido renal a partir da amostra ERA, frente a diferentes variantes antigênicas dos vírus da raiva. Utilizaram-se dois esquemas de vacinação, representados por uma única dose e por 6 doses aplicadas em dias alternados. Os diferentes camundogos dos grupos experimentais foram desafiados, em diversos períodos pós-imunização (15, 30, 60 e 120 dias), com variantes procedentes de cães (São Paulo e Nigéria), de morcego (DR-19 e Pernambuco), de raposa (Rio Grande do Norte) e CVS "Challenge Virus Standard". Os resultados obtidos permitiram constatar que a vacina ERA foi eficaz contra todas as variantes de rua e silváticas do vírus rábico, independentemente do esquema vacinal. Contra as cepas adaptadas no laboratório DR-19 e CVS, quando aplicada em uma única dose, sua eficácia foi menor do que quando aplicada em 6 doses. Universidade de São Paulo. Faculdade de Saúde Pública1990-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/2378010.1590/S0034-89101990000600010Revista de Saúde Pública; Vol. 24 No. 6 (1990); 512-517 Revista de Saúde Pública; Vol. 24 Núm. 6 (1990); 512-517 Revista de Saúde Pública; v. 24 n. 6 (1990); 512-517 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/23780/25816Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessCordeiro, Cláudia C.Silva, Egon V.Miguel, OrnarGermano, Pedro M. L.2012-05-28T20:49:16Zoai:revistas.usp.br:article/23780Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-05-28T20:49:16Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Evaluation of the ERA antirabies vaccine against antigenic variants of rabies virus in different post-immunization periods
Avaliação da vacina anti-rábica ERA, frente a variantes antigênicas do vírus da raiva, em diferentes períodos pós-imunização
title Evaluation of the ERA antirabies vaccine against antigenic variants of rabies virus in different post-immunization periods
spellingShingle Evaluation of the ERA antirabies vaccine against antigenic variants of rabies virus in different post-immunization periods
Cordeiro, Cláudia C.
Vacina antí-rábica
Eficácia
Raiva^i1^spreven
Rabies vaccine
Efficacy
Rabies^i2^sprevention and cont
title_short Evaluation of the ERA antirabies vaccine against antigenic variants of rabies virus in different post-immunization periods
title_full Evaluation of the ERA antirabies vaccine against antigenic variants of rabies virus in different post-immunization periods
title_fullStr Evaluation of the ERA antirabies vaccine against antigenic variants of rabies virus in different post-immunization periods
title_full_unstemmed Evaluation of the ERA antirabies vaccine against antigenic variants of rabies virus in different post-immunization periods
title_sort Evaluation of the ERA antirabies vaccine against antigenic variants of rabies virus in different post-immunization periods
author Cordeiro, Cláudia C.
author_facet Cordeiro, Cláudia C.
Silva, Egon V.
Miguel, Ornar
Germano, Pedro M. L.
author_role author
author2 Silva, Egon V.
Miguel, Ornar
Germano, Pedro M. L.
author2_role author
author
author
dc.contributor.author.fl_str_mv Cordeiro, Cláudia C.
Silva, Egon V.
Miguel, Ornar
Germano, Pedro M. L.
dc.subject.por.fl_str_mv Vacina antí-rábica
Eficácia
Raiva^i1^spreven
Rabies vaccine
Efficacy
Rabies^i2^sprevention and cont
topic Vacina antí-rábica
Eficácia
Raiva^i1^spreven
Rabies vaccine
Efficacy
Rabies^i2^sprevention and cont
description Protection levels of an attenuated antirabies vaccine, of ERA origin, prepared in Kidney tissue culture, were evaluated in mice. Two schemes of vaccination were utilized: a single dose and 6 doses on alternate days. Animals of different experimental groups were challenged at 15, 30, 60 and 120 days post-immunization with six antigenic variants of rabies virus: strains of dog origin (S. Paulo, Brazil and Nigéria), vampire origin (DR-19 and Pernambuco, Brazil), fox origin (Rio Grande do Norte,Brazil), and CVS (Challenge Virus Standard). The results showed the effectiveness of the ERA vaccine against all antigenic variants of street and sylvatic rabies virus, independently of the vaccination scheme. Against the laboratory strains (DR-19 and CVS) the ERA vaccine was less effective, mainly in the groups vaccinated with a single dose.
publishDate 1990
dc.date.none.fl_str_mv 1990-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/23780
10.1590/S0034-89101990000600010
url https://www.revistas.usp.br/rsp/article/view/23780
identifier_str_mv 10.1590/S0034-89101990000600010
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/23780/25816
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 24 No. 6 (1990); 512-517
Revista de Saúde Pública; Vol. 24 Núm. 6 (1990); 512-517
Revista de Saúde Pública; v. 24 n. 6 (1990); 512-517
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
_version_ 1800221775494119424

Registros relacionados