Evaluation of three antigenically different rabies virus strains in mice: I - Study of the clinical observation periods

Detalhes bibliográficos
Autor(a) principal: Germano, Pedro Manuel Leal
Data de Publicação: 1988
Outros Autores: Miguel, Omar, Ishizuka, Masaio Mizuno, Silva, Egon Vieira da
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/23520
Resumo: A study was conducted to compare three rabies virus strains, two of them, Jales and Nigeria, isolated from dogs, and the other, DR 19, from vampire bats, with different nucleocapside antigenic variations. These strains were intramuscularly inoculated in the inside part of the thigh of 21 and 28 day-old mice. The animals were observed for 30 days, in accordance with the clinical observation periods (incubation and illness). Mortality rates by age and viral strain were recorded. The brain pooled infective title of each experimental subgroup was determined. The results showed that Jales and Nigeria strains were similar when clinical observation periods and mortality rates were analysed for both age groups. However, these results were different from to those obtained for the DR 19 strain.
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spelling Evaluation of three antigenically different rabies virus strains in mice: I - Study of the clinical observation periods Avaliação de três cepas de vírus rábico, antigenicamente distintas, em camundongos: I - Estudo dos períodos de observação clínica Vírus da raivaAntígenos de vírusRaivaRabies virusAntigensviralRabies A study was conducted to compare three rabies virus strains, two of them, Jales and Nigeria, isolated from dogs, and the other, DR 19, from vampire bats, with different nucleocapside antigenic variations. These strains were intramuscularly inoculated in the inside part of the thigh of 21 and 28 day-old mice. The animals were observed for 30 days, in accordance with the clinical observation periods (incubation and illness). Mortality rates by age and viral strain were recorded. The brain pooled infective title of each experimental subgroup was determined. The results showed that Jales and Nigeria strains were similar when clinical observation periods and mortality rates were analysed for both age groups. However, these results were different from to those obtained for the DR 19 strain. Estudou-se, comparativamente, o comportamento de três cepas de vírus rábico, duas de origem de cão, Jales e Nigéria, e uma de origem de morcego, DR 19, com perfis antigênicos do nucleocapside distintos. Estas cepas foram inoculadas por via intramuscular, na face interna da coxa, em dois grupos de camundongos, com 21 e 28 dias de idade. Os animais foram observados durante 30 dias, levando-se em consideração os períodos de observação clínica (incubação e duração da doença), determinando-se os coeficientes de mortalidade para cada grupo etário e para cada uma das cepas virais, bem como o título infectante de pool de cérebros de cada sub-grupo experimental. Os resultados obtidos permitiram constatar comportamento semelhante entre as cepas Jales e Nigéria, notadamente em relação aos períodos de observação clínica e mortalidade, para ambos os grupos etários, diferindo, todavia, quando comparados aos da cepa DR 19. Universidade de São Paulo. Faculdade de Saúde Pública1988-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/2352010.1590/S0034-89101988000500002Revista de Saúde Pública; Vol. 22 No. 5 (1988); 375-383 Revista de Saúde Pública; Vol. 22 Núm. 5 (1988); 375-383 Revista de Saúde Pública; v. 22 n. 5 (1988); 375-383 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/23520/25557Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessGermano, Pedro Manuel LealMiguel, OmarIshizuka, Masaio MizunoSilva, Egon Vieira da2012-05-28T16:56:41Zoai:revistas.usp.br:article/23520Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-05-28T16:56:41Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Evaluation of three antigenically different rabies virus strains in mice: I - Study of the clinical observation periods
Avaliação de três cepas de vírus rábico, antigenicamente distintas, em camundongos: I - Estudo dos períodos de observação clínica
title Evaluation of three antigenically different rabies virus strains in mice: I - Study of the clinical observation periods
spellingShingle Evaluation of three antigenically different rabies virus strains in mice: I - Study of the clinical observation periods
Germano, Pedro Manuel Leal
Vírus da raiva
Antígenos de vírus
Raiva
Rabies virus
Antigens
viral
Rabies
title_short Evaluation of three antigenically different rabies virus strains in mice: I - Study of the clinical observation periods
title_full Evaluation of three antigenically different rabies virus strains in mice: I - Study of the clinical observation periods
title_fullStr Evaluation of three antigenically different rabies virus strains in mice: I - Study of the clinical observation periods
title_full_unstemmed Evaluation of three antigenically different rabies virus strains in mice: I - Study of the clinical observation periods
title_sort Evaluation of three antigenically different rabies virus strains in mice: I - Study of the clinical observation periods
author Germano, Pedro Manuel Leal
author_facet Germano, Pedro Manuel Leal
Miguel, Omar
Ishizuka, Masaio Mizuno
Silva, Egon Vieira da
author_role author
author2 Miguel, Omar
Ishizuka, Masaio Mizuno
Silva, Egon Vieira da
author2_role author
author
author
dc.contributor.author.fl_str_mv Germano, Pedro Manuel Leal
Miguel, Omar
Ishizuka, Masaio Mizuno
Silva, Egon Vieira da
dc.subject.por.fl_str_mv Vírus da raiva
Antígenos de vírus
Raiva
Rabies virus
Antigens
viral
Rabies
topic Vírus da raiva
Antígenos de vírus
Raiva
Rabies virus
Antigens
viral
Rabies
description A study was conducted to compare three rabies virus strains, two of them, Jales and Nigeria, isolated from dogs, and the other, DR 19, from vampire bats, with different nucleocapside antigenic variations. These strains were intramuscularly inoculated in the inside part of the thigh of 21 and 28 day-old mice. The animals were observed for 30 days, in accordance with the clinical observation periods (incubation and illness). Mortality rates by age and viral strain were recorded. The brain pooled infective title of each experimental subgroup was determined. The results showed that Jales and Nigeria strains were similar when clinical observation periods and mortality rates were analysed for both age groups. However, these results were different from to those obtained for the DR 19 strain.
publishDate 1988
dc.date.none.fl_str_mv 1988-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/23520
10.1590/S0034-89101988000500002
url https://www.revistas.usp.br/rsp/article/view/23520
identifier_str_mv 10.1590/S0034-89101988000500002
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/23520/25557
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 22 No. 5 (1988); 375-383
Revista de Saúde Pública; Vol. 22 Núm. 5 (1988); 375-383
Revista de Saúde Pública; v. 22 n. 5 (1988); 375-383
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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