Metabolic changes associated with antiretroviral therapy in HIV-positive patients

• Autor(a) principal: Almeida, Sabrina Esteves de Matos
• Data de Publicação: 2009
• Outros Autores: Borges, Michele, Fiegenbaum, Marilu, Nunes, Cynara Carvalho, Rossetti, Maria Lucia Rosa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista de Saúde Pública
• Texto Completo: https://www.revistas.usp.br/rsp/article/view/32597
• topic: HIV Infections^i1^sprevention & cont; Anti-HIV Agents^i1^sadverse effe; Comorbidity; Hepatitis C; Lipid Metabolism; Cholesterol^i1^sbl; Epidemiologic Studies; Infecções por HIV^i2^sprevenção & contr; Agentes Anti-HIV^i2^sefeitos adver; Comorbidade; Hepatite C; Metabolismo dos Lipídeos; Colesterol^i2^ssan; Estudos Epidemiológicos; Infecciones por VIH^i3^sprevención & cont; Agentes Anti VIH^i3^sefectos adver; Comorbilidad; Hepatitis C; Metabolismo de los Lípidos; Colesterol^i3^ssan; Estudios Epidemiológicos

OBJECTIVE: To evaluate metabolic changes associated with highly active antiretroviral therapy (HAART) in HIV-positive patients, and to identify risk factors associated. METHODS: Retrospective study that included 110 HIV-positive patients who where on HAART in the city of Porto Alegre (Southern Brazil) between January 2003 and March 2004. Data on demographic variables, cigarette smoking, diabetes mellitus, cholesterol and triglyceride levels, stage of HIV infection, antiretroviral therapy and HCV coinfection were collected. General linear models procedure for repeated measures was used to test the interaction between HAART and HCV coinfection or protease inhibitor treatment. RESULTS: Total cholesterol, triglycerides, and glucose levels significantly increased after receiving HAART (p