Towards a unified theory of health-disease: II. Holopathogenesis

Detalhes bibliográficos
Autor(a) principal: Almeida Filho, Naomar
Data de Publicação: 2014
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/81142
Resumo: This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.
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spelling Towards a unified theory of health-disease: II. HolopathogenesisHacia una teoría unificada de la salud y la enfermedad: II. HolopatogêneseTowards a unified theory of health-disease: II. HolopathogenesisThis article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.Este trabalho apresenta uma abordagem sistemática para a modelagem de várias classes de enfermidade-moléstia-doença, designada como Holopatogênese. Holopatogênese é definido como um processo de sobre-determinação de doenças e condições relacionadas, tomadas como um integral, compreendendo facetas selecionadas da saúde enquanto objeto complexo. Em primeiro lugar, o marco conceitual da Holopatogênese é apresentado como uma série de três interfaces significativas: biomolecular-imunológica, fisiopatológico-clínica e epidemiológico-ecossocial. Em segundo lugar, proposições derivadas da Holopatogênese são introduzidas a fim de permitir o desenho do complexo doença-enfermidade como uma rede hierárquica de redes. Em terceiro lugar, propõe-se uma formalização de correspondências intra- e inter-nível, processos de sobredeterminação, efeitos e laços componentes da Holopatogênese. Finalmente, o modelo Holopatogênese é avaliado como uma patologia teórica compreensiva tomada como passo preliminar para uma teoria unificada de saúde-doença.Universidade de São Paulo. Faculdade de Saúde Pública2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/8114210.1590/S0034-8910.2014048005196Revista de Saúde Pública; Vol. 48 No. 2 (2014); 192-205Revista de Saúde Pública; Vol. 48 Núm. 2 (2014); 192-205Revista de Saúde Pública; v. 48 n. 2 (2014); 192-2051518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/rsp/article/view/81142/84764Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessAlmeida Filho, Naomar2014-06-04T13:35:23Zoai:revistas.usp.br:article/81142Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2014-06-04T13:35:23Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Towards a unified theory of health-disease: II. Holopathogenesis
Hacia una teoría unificada de la salud y la enfermedad: II. Holopatogênese
Towards a unified theory of health-disease: II. Holopathogenesis
title Towards a unified theory of health-disease: II. Holopathogenesis
spellingShingle Towards a unified theory of health-disease: II. Holopathogenesis
Almeida Filho, Naomar
title_short Towards a unified theory of health-disease: II. Holopathogenesis
title_full Towards a unified theory of health-disease: II. Holopathogenesis
title_fullStr Towards a unified theory of health-disease: II. Holopathogenesis
title_full_unstemmed Towards a unified theory of health-disease: II. Holopathogenesis
title_sort Towards a unified theory of health-disease: II. Holopathogenesis
author Almeida Filho, Naomar
author_facet Almeida Filho, Naomar
author_role author
dc.contributor.author.fl_str_mv Almeida Filho, Naomar
description This article presents a systematic framework for modeling several classes of illness-sickness-disease named as Holopathogenesis. Holopathogenesis is defined as processes of over-determination of diseases and related conditions taken as a whole, comprising selected facets of the complex object Health. First, a conceptual background of Holopathogenesis is presented as a series of significant interfaces (biomolecular-immunological, physiopathological-clinical, epidemiological-ecosocial). Second, propositions derived from Holopathogenesis are introduced in order to allow drawing the disease-illness-sickness complex as a hierarchical network of networks. Third, a formalization of intra- and inter-level correspondences, over-determination processes, effects and links of Holopathogenesis models is proposed. Finally, the Holopathogenesis frame is evaluated as a comprehensive theoretical pathology taken as a preliminary step towards a unified theory of health-disease.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/81142
10.1590/S0034-8910.2014048005196
url https://www.revistas.usp.br/rsp/article/view/81142
identifier_str_mv 10.1590/S0034-8910.2014048005196
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/81142/84764
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 48 No. 2 (2014); 192-205
Revista de Saúde Pública; Vol. 48 Núm. 2 (2014); 192-205
Revista de Saúde Pública; v. 48 n. 2 (2014); 192-205
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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