Quality of life in individuals initiating antiretroviral therapy: a cohort study

Detalhes bibliográficos
Autor(a) principal: Pimentel,Gabriela Sales
Data de Publicação: 2020
Outros Autores: Ceccato,Maria das Graças Braga, Costa,Juliana de Oliveira, Mendes,Jullye Campos, Bonolo,Palmira de Fátima, Silveira,Micheline Rosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Saúde Pública
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102020000100316
Resumo: ABSTRACT OBJECTIVE To assess longitudinally the change in quality of life in people living with HIV initiating antiretroviral therapy in three public reference services specialized in HIV care in Belo Horizonte, Brazil. METHODS Prospective cohort study among people living with HIV, aged 18 years or older, and initiating antiretroviral therapy. We obtained sociodemographic, behavioral, clinical data related to pharmacological treatment and to the service by face-to-face interviews, and supplemented these data with information from clinical records and Information Systems of the Brazilian HIV/AIDS Program. We measured the quality of life using the WHOQOL-HIV bref instrument, with a minimum interval of six months between the baseline and the follow-up interviews. We used paired t-test to assess the mean change in quality of life between the two interviewsand evaluated factors associated with this outcome using multiple linear regression. RESULTS The overall quality of life, as well as the physical, psychological, level of independence, environment and spiritual quality of life domains were statistically higher in people living with HIV using antiretroviral therapy at the end of the follow-up. Factors independently associated with the increase in quality of life were having religious belief and living with other people. Having signs or symptoms of anxiety and depression and the number of adverse drug reactions reported were predictors associated with worsening quality of life. CONCLUSIONS These results show an improvement in the quality of life over time in people living with HIV on antiretroviral therapy. They also highlight the need to monitor and provide health care support, especially for individuals with signs and symptoms of anxiety and depression and that report adverse reactions to medicines at the beginning of treatment.
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spelling Quality of life in individuals initiating antiretroviral therapy: a cohort studyAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveQuality of LifeWHOQOLHIV-brefCohort StudiesABSTRACT OBJECTIVE To assess longitudinally the change in quality of life in people living with HIV initiating antiretroviral therapy in three public reference services specialized in HIV care in Belo Horizonte, Brazil. METHODS Prospective cohort study among people living with HIV, aged 18 years or older, and initiating antiretroviral therapy. We obtained sociodemographic, behavioral, clinical data related to pharmacological treatment and to the service by face-to-face interviews, and supplemented these data with information from clinical records and Information Systems of the Brazilian HIV/AIDS Program. We measured the quality of life using the WHOQOL-HIV bref instrument, with a minimum interval of six months between the baseline and the follow-up interviews. We used paired t-test to assess the mean change in quality of life between the two interviewsand evaluated factors associated with this outcome using multiple linear regression. RESULTS The overall quality of life, as well as the physical, psychological, level of independence, environment and spiritual quality of life domains were statistically higher in people living with HIV using antiretroviral therapy at the end of the follow-up. Factors independently associated with the increase in quality of life were having religious belief and living with other people. Having signs or symptoms of anxiety and depression and the number of adverse drug reactions reported were predictors associated with worsening quality of life. CONCLUSIONS These results show an improvement in the quality of life over time in people living with HIV on antiretroviral therapy. They also highlight the need to monitor and provide health care support, especially for individuals with signs and symptoms of anxiety and depression and that report adverse reactions to medicines at the beginning of treatment.Faculdade de Saúde Pública da Universidade de São Paulo2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102020000100316Revista de Saúde Pública v.54 2020reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USP10.11606/s1518-8787.2020054001920info:eu-repo/semantics/openAccessPimentel,Gabriela SalesCeccato,Maria das Graças BragaCosta,Juliana de OliveiraMendes,Jullye CamposBonolo,Palmira de FátimaSilveira,Micheline Rosaeng2020-12-14T00:00:00Zoai:scielo:S0034-89102020000100316Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0034-8910&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.phprevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2020-12-14T00:00Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Quality of life in individuals initiating antiretroviral therapy: a cohort study
title Quality of life in individuals initiating antiretroviral therapy: a cohort study
spellingShingle Quality of life in individuals initiating antiretroviral therapy: a cohort study
Pimentel,Gabriela Sales
Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Quality of Life
WHOQOLHIV-bref
Cohort Studies
title_short Quality of life in individuals initiating antiretroviral therapy: a cohort study
title_full Quality of life in individuals initiating antiretroviral therapy: a cohort study
title_fullStr Quality of life in individuals initiating antiretroviral therapy: a cohort study
title_full_unstemmed Quality of life in individuals initiating antiretroviral therapy: a cohort study
title_sort Quality of life in individuals initiating antiretroviral therapy: a cohort study
author Pimentel,Gabriela Sales
author_facet Pimentel,Gabriela Sales
Ceccato,Maria das Graças Braga
Costa,Juliana de Oliveira
Mendes,Jullye Campos
Bonolo,Palmira de Fátima
Silveira,Micheline Rosa
author_role author
author2 Ceccato,Maria das Graças Braga
Costa,Juliana de Oliveira
Mendes,Jullye Campos
Bonolo,Palmira de Fátima
Silveira,Micheline Rosa
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Pimentel,Gabriela Sales
Ceccato,Maria das Graças Braga
Costa,Juliana de Oliveira
Mendes,Jullye Campos
Bonolo,Palmira de Fátima
Silveira,Micheline Rosa
dc.subject.por.fl_str_mv Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Quality of Life
WHOQOLHIV-bref
Cohort Studies
topic Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Quality of Life
WHOQOLHIV-bref
Cohort Studies
description ABSTRACT OBJECTIVE To assess longitudinally the change in quality of life in people living with HIV initiating antiretroviral therapy in three public reference services specialized in HIV care in Belo Horizonte, Brazil. METHODS Prospective cohort study among people living with HIV, aged 18 years or older, and initiating antiretroviral therapy. We obtained sociodemographic, behavioral, clinical data related to pharmacological treatment and to the service by face-to-face interviews, and supplemented these data with information from clinical records and Information Systems of the Brazilian HIV/AIDS Program. We measured the quality of life using the WHOQOL-HIV bref instrument, with a minimum interval of six months between the baseline and the follow-up interviews. We used paired t-test to assess the mean change in quality of life between the two interviewsand evaluated factors associated with this outcome using multiple linear regression. RESULTS The overall quality of life, as well as the physical, psychological, level of independence, environment and spiritual quality of life domains were statistically higher in people living with HIV using antiretroviral therapy at the end of the follow-up. Factors independently associated with the increase in quality of life were having religious belief and living with other people. Having signs or symptoms of anxiety and depression and the number of adverse drug reactions reported were predictors associated with worsening quality of life. CONCLUSIONS These results show an improvement in the quality of life over time in people living with HIV on antiretroviral therapy. They also highlight the need to monitor and provide health care support, especially for individuals with signs and symptoms of anxiety and depression and that report adverse reactions to medicines at the beginning of treatment.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102020000100316
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.11606/s1518-8787.2020054001920
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Faculdade de Saúde Pública da Universidade de São Paulo
publisher.none.fl_str_mv Faculdade de Saúde Pública da Universidade de São Paulo
dc.source.none.fl_str_mv Revista de Saúde Pública v.54 2020
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
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reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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