Risk of drug interaction: combination of antidepressants and other drugs

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Autor(a) principal: Miyasaka, Lincoln Sakiara
Data de Publicação: 2003
Outros Autores: Atallah, Alvaro Nagib
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/31573
Resumo: OBJECTIVE: To assess the frequency of combination of antidepressants with other drugs and risk of drug interactions in the setting public hospital units in Brazil. METHODS: Prescriptions of all patients admitted to a public hospital from November 1996 to February 1997 were surveyed from the hospital's data processing center in São Paulo, Brazil. A manual search of case notes of all patients admitted to the psychiatric unit from January 1993 to December 1995 and all patients registered in the affective disorders outpatient clinic in December 1996 was carried out. Patients taking any antidepressant were identified and concomitant use of drugs was checked. By means of a software program (Micromedex®) drug interactions were identified. RESULTS: Out of 6,844 patients admitted to the hospital, 63 (0.9%) used antidepressants and 16 (25.3%) were at risk of drug interaction. Out of 311 patients in the psychiatric unit, 63 (20.2%) used antidepressants and 13 of them (20.6%) were at risk. Out of 87 patients in the affective disorders outpatient clinic, 43 (49.4%) took antidepressants and 7 (16.2%) were at risk. In general, the use of antidepressants was recorded in 169 patients and 36 (21.3%) were at risk of drug interactions. Twenty different forms of combinations at risk of drug interactions were identified: four were classified as mild, 15 moderate and one severe interaction. CONCLUSION: In the hospital general units the number of drug interactions per patient was higher than in the psychiatric unit; and prescription for depression was lower than expected.
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spelling Risk of drug interaction: combination of antidepressants and other drugs Risco de interação de drogas: combinações de uso de antidepressivos e outras drogas Interações de medicamentosAntidepressivosUso de medicamentosMedição de riscoPrescricao de medicamentosDrug interactionsAntidepressive agentsDrug utilizationRisk assessmentPrescriptionsdrug OBJECTIVE: To assess the frequency of combination of antidepressants with other drugs and risk of drug interactions in the setting public hospital units in Brazil. METHODS: Prescriptions of all patients admitted to a public hospital from November 1996 to February 1997 were surveyed from the hospital's data processing center in São Paulo, Brazil. A manual search of case notes of all patients admitted to the psychiatric unit from January 1993 to December 1995 and all patients registered in the affective disorders outpatient clinic in December 1996 was carried out. Patients taking any antidepressant were identified and concomitant use of drugs was checked. By means of a software program (Micromedex®) drug interactions were identified. RESULTS: Out of 6,844 patients admitted to the hospital, 63 (0.9%) used antidepressants and 16 (25.3%) were at risk of drug interaction. Out of 311 patients in the psychiatric unit, 63 (20.2%) used antidepressants and 13 of them (20.6%) were at risk. Out of 87 patients in the affective disorders outpatient clinic, 43 (49.4%) took antidepressants and 7 (16.2%) were at risk. In general, the use of antidepressants was recorded in 169 patients and 36 (21.3%) were at risk of drug interactions. Twenty different forms of combinations at risk of drug interactions were identified: four were classified as mild, 15 moderate and one severe interaction. CONCLUSION: In the hospital general units the number of drug interactions per patient was higher than in the psychiatric unit; and prescription for depression was lower than expected. OBJETIVO: Verificar a freqüência de combinações de antidepressivos com outros medicamentos e o risco de interações medicamentosas em um hospital público no Brasil. MÉTODOS: Prescrições de todos os pacientes internados em um hospital público, em São Paulo, SP, de novembro de 1996 a fevereiro de 1997 foram analisadas pelo centro de processamento de dados do hospital. Foi realizada busca manual de todos os prontuários de pacientes internados na enfermaria de psiquiatria do hospital de janeiro de 1993 a dezembro de 1995, assim como de todos os pacientes registrados no ambulatório de doenças afetivas em dezembro de 1996. Foram identificados os pacientes que usaram algum antidepressivo e as drogas utilizadas concomitantemente. Foram identificadas pelo programa Micromedex® as interações medicamentosas. RESULTADOS: Dentre os 6.844 pacientes internados nas enfermarias gerais (não psiquiátricas) do hospital, 63 usaram antidepressivos (0,9%) e 16 (25,3%) usavam medicações com risco de interação. Dentre os 311 pacientes da enfermaria de psiquiatria, 63 (20,2%) usavam antidepressivos e 13 (20,6%) apresentavam risco de interação. Dos 87 pacientes do ambulatório de doenças afetivas, 43 (49,4%) usavam antidepressivos e 7 (16,2%) apresentavam risco. Em geral, o uso de antidepressivos foi encontrado em 169 pacientes e 36 (21,3%) estavam em risco de interação medicamentosa. Vinte diferentes tipos de interações foram identificados, sendo 4 leves, 15 moderados e um grave. CONCLUSÕES: Nas enfermarias gerais o número de interações medicamentosas foi superior em relação à enfermaria de psiquiatria; e o número de prescrições de antidepressivos foi menor do que o esperado. Universidade de São Paulo. Faculdade de Saúde Pública2003-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/3157310.1590/S0034-89102003000200008Revista de Saúde Pública; Vol. 37 No. 2 (2003); 212-215 Revista de Saúde Pública; Vol. 37 Núm. 2 (2003); 212-215 Revista de Saúde Pública; v. 37 n. 2 (2003); 212-215 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/rsp/article/view/31573/33458Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessMiyasaka, Lincoln SakiaraAtallah, Alvaro Nagib2012-07-08T14:52:32Zoai:revistas.usp.br:article/31573Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-08T14:52:32Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Risk of drug interaction: combination of antidepressants and other drugs
Risco de interação de drogas: combinações de uso de antidepressivos e outras drogas
title Risk of drug interaction: combination of antidepressants and other drugs
spellingShingle Risk of drug interaction: combination of antidepressants and other drugs
Miyasaka, Lincoln Sakiara
Interações de medicamentos
Antidepressivos
Uso de medicamentos
Medição de risco
Prescricao de medicamentos
Drug interactions
Antidepressive agents
Drug utilization
Risk assessment
Prescriptions
drug
title_short Risk of drug interaction: combination of antidepressants and other drugs
title_full Risk of drug interaction: combination of antidepressants and other drugs
title_fullStr Risk of drug interaction: combination of antidepressants and other drugs
title_full_unstemmed Risk of drug interaction: combination of antidepressants and other drugs
title_sort Risk of drug interaction: combination of antidepressants and other drugs
author Miyasaka, Lincoln Sakiara
author_facet Miyasaka, Lincoln Sakiara
Atallah, Alvaro Nagib
author_role author
author2 Atallah, Alvaro Nagib
author2_role author
dc.contributor.author.fl_str_mv Miyasaka, Lincoln Sakiara
Atallah, Alvaro Nagib
dc.subject.por.fl_str_mv Interações de medicamentos
Antidepressivos
Uso de medicamentos
Medição de risco
Prescricao de medicamentos
Drug interactions
Antidepressive agents
Drug utilization
Risk assessment
Prescriptions
drug
topic Interações de medicamentos
Antidepressivos
Uso de medicamentos
Medição de risco
Prescricao de medicamentos
Drug interactions
Antidepressive agents
Drug utilization
Risk assessment
Prescriptions
drug
description OBJECTIVE: To assess the frequency of combination of antidepressants with other drugs and risk of drug interactions in the setting public hospital units in Brazil. METHODS: Prescriptions of all patients admitted to a public hospital from November 1996 to February 1997 were surveyed from the hospital's data processing center in São Paulo, Brazil. A manual search of case notes of all patients admitted to the psychiatric unit from January 1993 to December 1995 and all patients registered in the affective disorders outpatient clinic in December 1996 was carried out. Patients taking any antidepressant were identified and concomitant use of drugs was checked. By means of a software program (Micromedex®) drug interactions were identified. RESULTS: Out of 6,844 patients admitted to the hospital, 63 (0.9%) used antidepressants and 16 (25.3%) were at risk of drug interaction. Out of 311 patients in the psychiatric unit, 63 (20.2%) used antidepressants and 13 of them (20.6%) were at risk. Out of 87 patients in the affective disorders outpatient clinic, 43 (49.4%) took antidepressants and 7 (16.2%) were at risk. In general, the use of antidepressants was recorded in 169 patients and 36 (21.3%) were at risk of drug interactions. Twenty different forms of combinations at risk of drug interactions were identified: four were classified as mild, 15 moderate and one severe interaction. CONCLUSION: In the hospital general units the number of drug interactions per patient was higher than in the psychiatric unit; and prescription for depression was lower than expected.
publishDate 2003
dc.date.none.fl_str_mv 2003-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/31573
10.1590/S0034-89102003000200008
url https://www.revistas.usp.br/rsp/article/view/31573
identifier_str_mv 10.1590/S0034-89102003000200008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/31573/33458
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 37 No. 2 (2003); 212-215
Revista de Saúde Pública; Vol. 37 Núm. 2 (2003); 212-215
Revista de Saúde Pública; v. 37 n. 2 (2003); 212-215
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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