Risk factors for basal cell carcinoma: a case-control study
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/24085 |
Resumo: | A controlled trial was performed with the purpose of investigating which factors could be considered of significant risk for the development of basal cell carcinoma. A total of 259 cases of basal cell carcinoma diagnosed from July 1991 to July 1992 were compared with 518 controls matched for age and sex. All subjects in both groups were white. Protocol data were submitted to statistical analysis by the chi-square test and by multiple conditional logistic regression analysis and the following conclusions were reached: 1) light skin color (types I and II of the Fitzpatrick classification), odds ratio of 2.8; outdoor work under constant sunlight, odds ratio of 5.0; the presence of actinic lesions due to exposure to the sun, odds ratio of 4.9, are risk factors perse. 2) Type III skin in the Fitzpatrick classification only represents a risk factor when the patient reports a history of intense sunburns, but not in the absence of such a history. 3) Sunburns per se do not represent a risk factor althorig the point made in item 2 of these conclusions is valid. 4) Other suspected risk factors whose significance was not confirmed by multiple conditioned logistic regression analysis were: residence in rural areas, light eyes and blond hair color, extent of the awareness of the "sun x skin cancer" relationship, familial occurrence of skin cancer, excessive exposure to the sun, and freckles appearing in childhood. |
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Risk factors for basal cell carcinoma: a case-control study Carcinoma basocelular^i2^sepidemioloFatores de riscoCarcinomabasal cell^i1^sepidemiolRisk factors A controlled trial was performed with the purpose of investigating which factors could be considered of significant risk for the development of basal cell carcinoma. A total of 259 cases of basal cell carcinoma diagnosed from July 1991 to July 1992 were compared with 518 controls matched for age and sex. All subjects in both groups were white. Protocol data were submitted to statistical analysis by the chi-square test and by multiple conditional logistic regression analysis and the following conclusions were reached: 1) light skin color (types I and II of the Fitzpatrick classification), odds ratio of 2.8; outdoor work under constant sunlight, odds ratio of 5.0; the presence of actinic lesions due to exposure to the sun, odds ratio of 4.9, are risk factors perse. 2) Type III skin in the Fitzpatrick classification only represents a risk factor when the patient reports a history of intense sunburns, but not in the absence of such a history. 3) Sunburns per se do not represent a risk factor althorig the point made in item 2 of these conclusions is valid. 4) Other suspected risk factors whose significance was not confirmed by multiple conditioned logistic regression analysis were: residence in rural areas, light eyes and blond hair color, extent of the awareness of the "sun x skin cancer" relationship, familial occurrence of skin cancer, excessive exposure to the sun, and freckles appearing in childhood. Realizou-se estudo controlado para investigar quais os fatores de risco, para o desenvolvimento do carcinoma basocelular, são significantes. Foram utilizados 259 casos de carcinoma basocelular (diagnosticados entre julho de 1991 e julho de 1992) e 518 controles, pareados segundo sexo e idade. Submetidos os dados constantes do protocolo à análise estatística (Qui-quadrado e Regressão Logística Múltipla Condicional), foi possível obter as seguintes conclusões na população estudada: 1 - Representam fatores de risco, por si só: - as peles claras de tipo l e II de Fitzpatrick; - a atividade profissional desenvolvida sob exposição constante à luz solar (atividade agropecuária); - a presença de alterações cutâneas decorrentes da exposição crônica à radiação solar. 2 - A pele do tipo III, na classificação de Fitzpatrick, representa fator de risco somente quando há história anterior de queimaduras solares intensas; já em ausência destas queimaduras anteriores, a pele do tipo III passa para o grupo de não-risco. 3 - Os fatores de risco assinalados puderam ser incluídos na equação logarítimica que expressa o Modelo Logístico de Probabilidade de Doença: 1,6041.x1 + 1,5938.x2 + 1,0208.x3 onde x1 é a atividade agropecuária, x2 são as alterações actínicas de pele e x3 o tipo de pele. 4 - Queimaduras solares não representam fator de risco, embora seja válida a ressalva feita no item 2, destas conclusões. 5 - Os outros fatores suspeitos de risco e não confirmados pela Análise de Regressão Logística Múltipla Condicional foram: residência em área rural, olhos e cabelos claros, nível de informação sobre a relação sol X câncer de pele, história familiar de câncer de pele, exposição solar intensa e aparecimento de efélides na infância. Universidade de São Paulo. Faculdade de Saúde Pública1995-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/2408510.1590/S0034-89101995000100006Revista de Saúde Pública; Vol. 29 No. 1 (1995); 27-37 Revista de Saúde Pública; Vol. 29 Núm. 1 (1995); 27-37 Revista de Saúde Pública; v. 29 n. 1 (1995); 27-37 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/rsp/article/view/24085/26050Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessMaia, MarcusProença, Nelson GuimarãesMoraes, José Cássio de2012-05-29T16:26:32Zoai:revistas.usp.br:article/24085Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-05-29T16:26:32Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Risk factors for basal cell carcinoma: a case-control study |
title |
Risk factors for basal cell carcinoma: a case-control study |
spellingShingle |
Risk factors for basal cell carcinoma: a case-control study Maia, Marcus Carcinoma basocelular^i2^sepidemiolo Fatores de risco Carcinoma basal cell^i1^sepidemiol Risk factors |
title_short |
Risk factors for basal cell carcinoma: a case-control study |
title_full |
Risk factors for basal cell carcinoma: a case-control study |
title_fullStr |
Risk factors for basal cell carcinoma: a case-control study |
title_full_unstemmed |
Risk factors for basal cell carcinoma: a case-control study |
title_sort |
Risk factors for basal cell carcinoma: a case-control study |
author |
Maia, Marcus |
author_facet |
Maia, Marcus Proença, Nelson Guimarães Moraes, José Cássio de |
author_role |
author |
author2 |
Proença, Nelson Guimarães Moraes, José Cássio de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Maia, Marcus Proença, Nelson Guimarães Moraes, José Cássio de |
dc.subject.por.fl_str_mv |
Carcinoma basocelular^i2^sepidemiolo Fatores de risco Carcinoma basal cell^i1^sepidemiol Risk factors |
topic |
Carcinoma basocelular^i2^sepidemiolo Fatores de risco Carcinoma basal cell^i1^sepidemiol Risk factors |
description |
A controlled trial was performed with the purpose of investigating which factors could be considered of significant risk for the development of basal cell carcinoma. A total of 259 cases of basal cell carcinoma diagnosed from July 1991 to July 1992 were compared with 518 controls matched for age and sex. All subjects in both groups were white. Protocol data were submitted to statistical analysis by the chi-square test and by multiple conditional logistic regression analysis and the following conclusions were reached: 1) light skin color (types I and II of the Fitzpatrick classification), odds ratio of 2.8; outdoor work under constant sunlight, odds ratio of 5.0; the presence of actinic lesions due to exposure to the sun, odds ratio of 4.9, are risk factors perse. 2) Type III skin in the Fitzpatrick classification only represents a risk factor when the patient reports a history of intense sunburns, but not in the absence of such a history. 3) Sunburns per se do not represent a risk factor althorig the point made in item 2 of these conclusions is valid. 4) Other suspected risk factors whose significance was not confirmed by multiple conditioned logistic regression analysis were: residence in rural areas, light eyes and blond hair color, extent of the awareness of the "sun x skin cancer" relationship, familial occurrence of skin cancer, excessive exposure to the sun, and freckles appearing in childhood. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/24085 10.1590/S0034-89101995000100006 |
url |
https://www.revistas.usp.br/rsp/article/view/24085 |
identifier_str_mv |
10.1590/S0034-89101995000100006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/24085/26050 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista de Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista de Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 29 No. 1 (1995); 27-37 Revista de Saúde Pública; Vol. 29 Núm. 1 (1995); 27-37 Revista de Saúde Pública; v. 29 n. 1 (1995); 27-37 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1800221777072226304 |