Epidemiological profile of patients on renal replacement therapy in Brazil, 2000-2004

Detalhes bibliográficos
Autor(a) principal: Cherchiglia, Mariangela Leal
Data de Publicação: 2010
Outros Autores: Machado, Elaine Leandro, Szuster, Daniele Araújo Campo, Andrade, Eli Iola Gurgel, Acúrcio, Francisco de Assis, Caiaffa, Waleska Teixeira, Sesso, Ricardo, Guerra Junior, Augusto A, Queiroz, Odilon Vanni de, Gomes, Isabel Cristina
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/32814
Resumo: OBJECTIVE: To describe the clinical and epidemiological profile of patients under renal replacement therapies, identifying risk factors for death. METHODS: This is a non-concurrent cohort study of data for 90,356 patients in the National Renal Replacement Therapies Database. A deterministic-probabilistic linkage was performed using the Authorization System for High Complexity/Cost Procedures and the Mortality Information System databases. All patients who started dialysis between 1/1/2000 and 12/31/2004 were included and followed until death or the end of 2004. Age, sex, region of residence, primary renal disease and causes of death were analyzed. A proportional hazards model was used to identify factors associated with risk of death. RESULTS: The prevalence of patients under renal replacement therapies increased an average of 5.5%, while incidence remained stable during the period. Hemodialysis was the predominant initial modality (89%). The patients were majority male with mean age 53 years, residents of the Southeast region and presented unknown causes as the main cause of chronic renal disease, followed by hypertension, diabetes and glomerulonephritis. Of these patients, 42% progressed to death and 7% underwent kidney transplantation. The patients on peritoneal dialysis were older and had higher prevalence of diabetes. The death rate varied from 7% among transplanted patients to 45% among non-transplanted patients. In the final Cox proportional hazards model, the risk of mortality was associated with increasing age, female sex, having diabetes, living in the North and Northeast region, peritoneal dialysis as a first modality and not having renal transplantation. CONCLUSIONS: There was an increased prevalence of patients on renal therapy in Brazil. Increased risk of death was associated with advanced age, diabetes, the female sex, residents of the North and Northeast region and lack of renal transplant.
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spelling Epidemiological profile of patients on renal replacement therapy in Brazil, 2000-2004 Perfil epidemiológico de los pacientes en terapia renal substitutiva en Brasil, 2000-2004 Perfil epidemiológico dos pacientes em terapia renal substitutiva no Brasil, 2000-2004 Insuficiência Renal Crônica^i1^sepidemioloTerapia de Substituição RenalSistemas de Informação HospitalarRegistros de MortalidadeInsuficiencia Renal Crónica^i3^sepidemioloTerapia de Reemplazo RenalSistemas de Información en HospitalRegistros de MortalidadRenal InsufficiencyChronic^i2^sepidemiolRenal Replacement TherapyHospital Information SystemsMortality Registries OBJECTIVE: To describe the clinical and epidemiological profile of patients under renal replacement therapies, identifying risk factors for death. METHODS: This is a non-concurrent cohort study of data for 90,356 patients in the National Renal Replacement Therapies Database. A deterministic-probabilistic linkage was performed using the Authorization System for High Complexity/Cost Procedures and the Mortality Information System databases. All patients who started dialysis between 1/1/2000 and 12/31/2004 were included and followed until death or the end of 2004. Age, sex, region of residence, primary renal disease and causes of death were analyzed. A proportional hazards model was used to identify factors associated with risk of death. RESULTS: The prevalence of patients under renal replacement therapies increased an average of 5.5%, while incidence remained stable during the period. Hemodialysis was the predominant initial modality (89%). The patients were majority male with mean age 53 years, residents of the Southeast region and presented unknown causes as the main cause of chronic renal disease, followed by hypertension, diabetes and glomerulonephritis. Of these patients, 42% progressed to death and 7% underwent kidney transplantation. The patients on peritoneal dialysis were older and had higher prevalence of diabetes. The death rate varied from 7% among transplanted patients to 45% among non-transplanted patients. In the final Cox proportional hazards model, the risk of mortality was associated with increasing age, female sex, having diabetes, living in the North and Northeast region, peritoneal dialysis as a first modality and not having renal transplantation. CONCLUSIONS: There was an increased prevalence of patients on renal therapy in Brazil. Increased risk of death was associated with advanced age, diabetes, the female sex, residents of the North and Northeast region and lack of renal transplant. OBJETIVO: Describir el perfil epidemiológico y clínico de pacientes en terapia renal substitutiva, identificando factores asociados al riesgo de muerte. MÉTODOS: Estudio de observación, prospectivo no concurrente, a partir de datos de 90.356 pacientes de la Base Nacional en Terapias Renales Substitutivas, en Brasil. Fue realizado reracionamiento determinístico-probabilístico del Sistema de Información de Mortalidad. Fueron incluidos todos los pacientes incidentes que iniciaron diálisis entre 1/1/2000 y 31/12/2004, acompañados hasta la muerte o final de 2004. Edad, sexo, región de residencia, enfermedad renal primaria, causa del óbito fueron analizados. Se ajustó un modelo de riesgos proporcionales para identificar factores asociados al riesgo de muerte. RESULTADOS: Ocurrió un aumento promedio de 5,5% en la prevalencia de pacientes en terapia, con relación a la incidencia se mantuvo estable en el período. Hemodiálisis fue la modalidad inicial predominante (89%). La mayoría de los pacientes era del sexo masculino, con edad promedio de 53 años, residente en la región Sureste y presentaba causa indeterminada como principal causa básica de la enfermedad renal crónica, seguida de la hipertensión, diabetes y glomerulonefritis. De esos pacientes, 7% realizaron transplante renal y 42% evolucionaron a óbito. Los pacientes en diálisis peritoneal eran más ancianos y presentaban mayor prevalencia de diabetes. Entre los no transplantados, 45% fueron a óbito y, entre los transplantadas 7%. En el modelo final de riesgos proporcionales de Cox, el riesgo de mortalidad estuvo asociado con el aumento de la edad, sexo femenino, tener diabetes, residir en la región Norte y Noreste, diálisis peritoneal como modalidad de entrada y no haber realizado transplante renal. CONCLUSIONES: Hubo aumento de la prevalencia de pacientes en terapia renal en Brasil. Pacientes con edad avanzada, diabetes, del sexo femenino, residentes en la región Norte y Noreste y sin transplante renal presentan mayor riesgo de muerte. OBJETIVO: Descrever o perfil epidemiológico e clínico de pacientes em terapia renal substitutiva, identificando fatores associados ao risco de morte. MÉTODOS: Estudo observacional, prospectivo não concorrente, a partir de dados de 90.356 pacientes da Base Nacional em Terapias Renais Substitutivas, no Brasil. Foi realizado relacionamento determinístico-probabilístico do Sistema de Autorização de Procedimentos de Alta Complexidade/Custo e do Sistema de Informação de Mortalidade. Foram incluídos todos os pacientes incidentes que iniciaram diálise entre 1/1/2000 e 31/12/2004, acompanhados até a morte ou final de 2004. Idade, sexo, região de residência, doença renal primária, causa do óbito foram analisados. Ajustou-se um modelo de riscos proporcionais para identificar fatores associados ao risco de morte. RESULTADOS: Ocorreu um aumento médio de 5,5% na prevalência de pacientes em terapia enquanto a incidência manteve-se estável no período. Hemodiálise foi a modalidade inicial predominante (89%). A maioria dos pacientes era do sexo masculino, com idade média de 53 anos, residente na região Sudeste, e apresentava causa indeterminada como principal causa básica da doença renal crônica, seguida da hipertensão, diabetes e glomerulonefrites. Desses pacientes, 7% realizou transplante renal e 42% evoluiu para o óbito. Os pacientes em diálise peritoneal eram mais idosos e apresentavam maior prevalência de diabetes. Entre os não transplantados, 45% foi a óbito e, entre os transplantados, 7%. No modelo final de riscos proporcionais de Cox, o risco de mortalidade foi associado com o aumento da idade, sexo feminino, ter diabetes, residir nas regiões Norte e Nordeste, diálise peritoneal como modalidade de entrada e não ter realizado transplante renal. CONCLUSÕES: Houve aumento da prevalência de pacientes em terapia renal no Brasil. Pacientes com idade avançada, diabetes, do sexo feminino, residentes nas regiões Norte e Nordeste e sem transplante renal apresentam maior risco de morte. Universidade de São Paulo. Faculdade de Saúde Pública2010-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/3281410.1590/S0034-89102010000400007Revista de Saúde Pública; Vol. 44 No. 4 (2010); 639-649 Revista de Saúde Pública; Vol. 44 Núm. 4 (2010); 639-649 Revista de Saúde Pública; v. 44 n. 4 (2010); 639-649 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporenghttps://www.revistas.usp.br/rsp/article/view/32814/35334https://www.revistas.usp.br/rsp/article/view/32814/35335Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessCherchiglia, Mariangela LealMachado, Elaine LeandroSzuster, Daniele Araújo CampoAndrade, Eli Iola GurgelAcúrcio, Francisco de AssisCaiaffa, Waleska TeixeiraSesso, RicardoGuerra Junior, Augusto AQueiroz, Odilon Vanni deGomes, Isabel Cristina2012-07-10T02:23:36Zoai:revistas.usp.br:article/32814Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-10T02:23:36Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Epidemiological profile of patients on renal replacement therapy in Brazil, 2000-2004
Perfil epidemiológico de los pacientes en terapia renal substitutiva en Brasil, 2000-2004
Perfil epidemiológico dos pacientes em terapia renal substitutiva no Brasil, 2000-2004
title Epidemiological profile of patients on renal replacement therapy in Brazil, 2000-2004
spellingShingle Epidemiological profile of patients on renal replacement therapy in Brazil, 2000-2004
Cherchiglia, Mariangela Leal
Insuficiência Renal Crônica^i1^sepidemiolo
Terapia de Substituição Renal
Sistemas de Informação Hospitalar
Registros de Mortalidade
Insuficiencia Renal Crónica^i3^sepidemiolo
Terapia de Reemplazo Renal
Sistemas de Información en Hospital
Registros de Mortalidad
Renal Insufficiency
Chronic^i2^sepidemiol
Renal Replacement Therapy
Hospital Information Systems
Mortality Registries
title_short Epidemiological profile of patients on renal replacement therapy in Brazil, 2000-2004
title_full Epidemiological profile of patients on renal replacement therapy in Brazil, 2000-2004
title_fullStr Epidemiological profile of patients on renal replacement therapy in Brazil, 2000-2004
title_full_unstemmed Epidemiological profile of patients on renal replacement therapy in Brazil, 2000-2004
title_sort Epidemiological profile of patients on renal replacement therapy in Brazil, 2000-2004
author Cherchiglia, Mariangela Leal
author_facet Cherchiglia, Mariangela Leal
Machado, Elaine Leandro
Szuster, Daniele Araújo Campo
Andrade, Eli Iola Gurgel
Acúrcio, Francisco de Assis
Caiaffa, Waleska Teixeira
Sesso, Ricardo
Guerra Junior, Augusto A
Queiroz, Odilon Vanni de
Gomes, Isabel Cristina
author_role author
author2 Machado, Elaine Leandro
Szuster, Daniele Araújo Campo
Andrade, Eli Iola Gurgel
Acúrcio, Francisco de Assis
Caiaffa, Waleska Teixeira
Sesso, Ricardo
Guerra Junior, Augusto A
Queiroz, Odilon Vanni de
Gomes, Isabel Cristina
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cherchiglia, Mariangela Leal
Machado, Elaine Leandro
Szuster, Daniele Araújo Campo
Andrade, Eli Iola Gurgel
Acúrcio, Francisco de Assis
Caiaffa, Waleska Teixeira
Sesso, Ricardo
Guerra Junior, Augusto A
Queiroz, Odilon Vanni de
Gomes, Isabel Cristina
dc.subject.por.fl_str_mv Insuficiência Renal Crônica^i1^sepidemiolo
Terapia de Substituição Renal
Sistemas de Informação Hospitalar
Registros de Mortalidade
Insuficiencia Renal Crónica^i3^sepidemiolo
Terapia de Reemplazo Renal
Sistemas de Información en Hospital
Registros de Mortalidad
Renal Insufficiency
Chronic^i2^sepidemiol
Renal Replacement Therapy
Hospital Information Systems
Mortality Registries
topic Insuficiência Renal Crônica^i1^sepidemiolo
Terapia de Substituição Renal
Sistemas de Informação Hospitalar
Registros de Mortalidade
Insuficiencia Renal Crónica^i3^sepidemiolo
Terapia de Reemplazo Renal
Sistemas de Información en Hospital
Registros de Mortalidad
Renal Insufficiency
Chronic^i2^sepidemiol
Renal Replacement Therapy
Hospital Information Systems
Mortality Registries
description OBJECTIVE: To describe the clinical and epidemiological profile of patients under renal replacement therapies, identifying risk factors for death. METHODS: This is a non-concurrent cohort study of data for 90,356 patients in the National Renal Replacement Therapies Database. A deterministic-probabilistic linkage was performed using the Authorization System for High Complexity/Cost Procedures and the Mortality Information System databases. All patients who started dialysis between 1/1/2000 and 12/31/2004 were included and followed until death or the end of 2004. Age, sex, region of residence, primary renal disease and causes of death were analyzed. A proportional hazards model was used to identify factors associated with risk of death. RESULTS: The prevalence of patients under renal replacement therapies increased an average of 5.5%, while incidence remained stable during the period. Hemodialysis was the predominant initial modality (89%). The patients were majority male with mean age 53 years, residents of the Southeast region and presented unknown causes as the main cause of chronic renal disease, followed by hypertension, diabetes and glomerulonephritis. Of these patients, 42% progressed to death and 7% underwent kidney transplantation. The patients on peritoneal dialysis were older and had higher prevalence of diabetes. The death rate varied from 7% among transplanted patients to 45% among non-transplanted patients. In the final Cox proportional hazards model, the risk of mortality was associated with increasing age, female sex, having diabetes, living in the North and Northeast region, peritoneal dialysis as a first modality and not having renal transplantation. CONCLUSIONS: There was an increased prevalence of patients on renal therapy in Brazil. Increased risk of death was associated with advanced age, diabetes, the female sex, residents of the North and Northeast region and lack of renal transplant.
publishDate 2010
dc.date.none.fl_str_mv 2010-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/32814
10.1590/S0034-89102010000400007
url https://www.revistas.usp.br/rsp/article/view/32814
identifier_str_mv 10.1590/S0034-89102010000400007
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/32814/35334
https://www.revistas.usp.br/rsp/article/view/32814/35335
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 44 No. 4 (2010); 639-649
Revista de Saúde Pública; Vol. 44 Núm. 4 (2010); 639-649
Revista de Saúde Pública; v. 44 n. 4 (2010); 639-649
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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