A case-control study on the association of hepatitis B virus infection and hepatocellular carcinoma in Northeast Brazil
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89101992000500001 |
Resumo: | Hepatitis B virus (HBV) serological markers were investigated in 40 incident cases of hepatocellular carcinoma (HCC) and in two age and sex matched control groups, comprising 40 patients with other cancers and 80 healthy individuals, resident in Bahia, Brazil. Serologic tests were done by radioimmunoassay. The study observed high proportion of seropositivity to HBsAg (42.5%) and of those presenting HBsAg or antiHBc (65.0%) among HCC cases, higher in men than women and in those aged 17 to 30 years old. HBsAg seropositivity among HCC patients was greater than in the control group with other cancers (7.5%) and in healthy controls (2.5%), corresponding to odds ratio estimates of 15.0 (95% CI 3.29, 68.30) and 33.0 (95% CI 9.13, 119.28), both statistically significant. HBeAg was not observed and antiHBe was present in 41.2% of cases, suggesting the absence of viral replication, possibly with viral DNA intergration into the hepatocyte genome. The presence of cirrhosis was associated with HBsAg seropositivity among HCC cases. A history of chronic alcoholism is shown to be more frequently related to those cases with cirrhosis. This study highlights the relevant association between HCC and HBV in Northeast Brazil, particularly for young individuals, and the high risk of development of HCC for HBsAg carriers. |
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A case-control study on the association of hepatitis B virus infection and hepatocellular carcinoma in Northeast BrazilHepatitis B/complicationsHepatoma/complicationsRisk factorsLiver neoplasms/complicationsHepatitis B virus (HBV) serological markers were investigated in 40 incident cases of hepatocellular carcinoma (HCC) and in two age and sex matched control groups, comprising 40 patients with other cancers and 80 healthy individuals, resident in Bahia, Brazil. Serologic tests were done by radioimmunoassay. The study observed high proportion of seropositivity to HBsAg (42.5%) and of those presenting HBsAg or antiHBc (65.0%) among HCC cases, higher in men than women and in those aged 17 to 30 years old. HBsAg seropositivity among HCC patients was greater than in the control group with other cancers (7.5%) and in healthy controls (2.5%), corresponding to odds ratio estimates of 15.0 (95% CI 3.29, 68.30) and 33.0 (95% CI 9.13, 119.28), both statistically significant. HBeAg was not observed and antiHBe was present in 41.2% of cases, suggesting the absence of viral replication, possibly with viral DNA intergration into the hepatocyte genome. The presence of cirrhosis was associated with HBsAg seropositivity among HCC cases. A history of chronic alcoholism is shown to be more frequently related to those cases with cirrhosis. This study highlights the relevant association between HCC and HBV in Northeast Brazil, particularly for young individuals, and the high risk of development of HCC for HBsAg carriers.Faculdade de Saúde Pública da Universidade de São Paulo1992-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89101992000500001Revista de Saúde Pública v.26 n.5 1992reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0034-89101992000500001info:eu-repo/semantics/openAccessCotrim,HelmaMota,EduardoLeite,LiviaSilva,LucianaLyra,Luizeng2003-12-23T00:00:00Zoai:scielo:S0034-89101992000500001Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0034-8910&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.phprevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2003-12-23T00:00Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
A case-control study on the association of hepatitis B virus infection and hepatocellular carcinoma in Northeast Brazil |
title |
A case-control study on the association of hepatitis B virus infection and hepatocellular carcinoma in Northeast Brazil |
spellingShingle |
A case-control study on the association of hepatitis B virus infection and hepatocellular carcinoma in Northeast Brazil Cotrim,Helma Hepatitis B/complications Hepatoma/complications Risk factors Liver neoplasms/complications |
title_short |
A case-control study on the association of hepatitis B virus infection and hepatocellular carcinoma in Northeast Brazil |
title_full |
A case-control study on the association of hepatitis B virus infection and hepatocellular carcinoma in Northeast Brazil |
title_fullStr |
A case-control study on the association of hepatitis B virus infection and hepatocellular carcinoma in Northeast Brazil |
title_full_unstemmed |
A case-control study on the association of hepatitis B virus infection and hepatocellular carcinoma in Northeast Brazil |
title_sort |
A case-control study on the association of hepatitis B virus infection and hepatocellular carcinoma in Northeast Brazil |
author |
Cotrim,Helma |
author_facet |
Cotrim,Helma Mota,Eduardo Leite,Livia Silva,Luciana Lyra,Luiz |
author_role |
author |
author2 |
Mota,Eduardo Leite,Livia Silva,Luciana Lyra,Luiz |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Cotrim,Helma Mota,Eduardo Leite,Livia Silva,Luciana Lyra,Luiz |
dc.subject.por.fl_str_mv |
Hepatitis B/complications Hepatoma/complications Risk factors Liver neoplasms/complications |
topic |
Hepatitis B/complications Hepatoma/complications Risk factors Liver neoplasms/complications |
description |
Hepatitis B virus (HBV) serological markers were investigated in 40 incident cases of hepatocellular carcinoma (HCC) and in two age and sex matched control groups, comprising 40 patients with other cancers and 80 healthy individuals, resident in Bahia, Brazil. Serologic tests were done by radioimmunoassay. The study observed high proportion of seropositivity to HBsAg (42.5%) and of those presenting HBsAg or antiHBc (65.0%) among HCC cases, higher in men than women and in those aged 17 to 30 years old. HBsAg seropositivity among HCC patients was greater than in the control group with other cancers (7.5%) and in healthy controls (2.5%), corresponding to odds ratio estimates of 15.0 (95% CI 3.29, 68.30) and 33.0 (95% CI 9.13, 119.28), both statistically significant. HBeAg was not observed and antiHBe was present in 41.2% of cases, suggesting the absence of viral replication, possibly with viral DNA intergration into the hepatocyte genome. The presence of cirrhosis was associated with HBsAg seropositivity among HCC cases. A history of chronic alcoholism is shown to be more frequently related to those cases with cirrhosis. This study highlights the relevant association between HCC and HBV in Northeast Brazil, particularly for young individuals, and the high risk of development of HCC for HBsAg carriers. |
publishDate |
1992 |
dc.date.none.fl_str_mv |
1992-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89101992000500001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89101992000500001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0034-89101992000500001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade de Saúde Pública da Universidade de São Paulo |
publisher.none.fl_str_mv |
Faculdade de Saúde Pública da Universidade de São Paulo |
dc.source.none.fl_str_mv |
Revista de Saúde Pública v.26 n.5 1992 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1748936489891266560 |