Coinfección por HIV/HCV en hospital universitario de Recife, Brasil

• Autor(a) principal: Carvalho, Flávia Helena Pontes de
• Data de Publicação: 2009
• Outros Autores: Coêlho, Maria Rosângela Cunha Duarte, Vilella, Tatiana de Aguiar Santos, Silva, Jéfferson Luis Almeida, Melo, Heloísa Ramos de Lacerda
• Tipo de documento: Artigo
• Idioma: por; eng
• Título da fonte: Revista de Saúde Pública
• Texto Completo: https://www.revistas.usp.br/rsp/article/view/32577
• topic: Infecções por HIV^i1^sepidemiolo; Hepatite C^i1^sepidemiolo; Fatores de Risco; Estudos Soroepidemiológicos; Estudos Transversais; Infecciones por VIH^i3^sepidemiolo; Hepatitis C^i3^sepidemiolo; Factores de Riesgo; Estudios Seroepidemiológicos; Estudios Transversales; HIV Infections^i2^sepidemiol; Hepatitis C^i2^sepidemiol; Risk Factors; Seroepidemiologic Studies; Cross-Sectional Studies

OBJECTIVE: To estimate the prevalence of hepatitis C virus (HCV) infection and risks factors associated with coinfection in HIV-positive individuals. METHODS: A cross-sectional descriptive study was conducted with 343 HIV patients attended at a university hospital in Recife, Northeastern Brazil, from March to December 2003. A standardized questionnaire about risk factors was administered. Serum samples were analyzed for anti-HCV antibodies using enzyme-linked immunosorbent assay (ELISA), HCV-RNA using reverse transcription-polymerase chain reaction (RT-PCR), and genotyping using the ABI 377 (PE Biosystems®). Univariate and multivariate analyses and multiple logistic regression were performed. RESULTS: HCV prevalence was 4.1% (14/343) using ELISA and 3.2% (11/343) using RT-PCR. The most common genotypes were 1b (45%), 3 (33%) and 1a (22%). Co-infection was higher among those aged 30 to 39 years, and predominantly in males (64.3 %). In the multiple logistic regression, the variable blood transfusion was the single remaining risk factor for HCV (OR=4.28; 95% CI 1.44;12.73). CONCLUSIONS: The prevalence of HIV/HCV coinfection was low. Blood transfusion was a risk factor and HCV genotype 1b was the most frequently found.