Liver enzyme abnormalities among oil refinery workers
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/31987 |
Resumo: | OBJECTIVE: Occupational exposure typical of an oil refinery may alter liver function among the workers. Thus, the objective of the study was to identify risk factors for liver enzyme abnormalities among oil refinery workers. METHODS: The workers at an oil refinery in Northeastern Brazil underwent routine annual medical examination from 1982 to 1998. This case-control study investigated all the 150 cases of individuals with simultaneous gamma-glutamyltransferase and alanine aminotransferase abnormalities of at least 10% above reference levels. As controls, 150 workers without any liver enzyme or bilirubin abnormalities since starting to work there were selected. Odds ratios and the respective 95% confidence intervals were calculated from logistic regression models. RESULTS: In all the production sectors, the risk of liver enzyme abnormalities was significantly higher than in the administrative sector (OR=5.7; 95% CI: 1.7-18.4), even when the effects of alcohol, obesity and medical history of hepatitis were controlled for. During the period from 1992 to 1994, 88 out of the 89 cases occurred among workers from the various production sectors. CONCLUSIONS: Occupational exposure plays an important role in causing liver enzyme abnormalities among oil refinery workers. This is in addition to the specifically biological and/or behavioral risk factors such as obesity and alcohol consumption. |
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Liver enzyme abnormalities among oil refinery workers Alteração de enzimas hepáticas em trabalhadores de refinaria de petróleo Indústria petroquímicaExposição ocupacional^i1^sefeitos adverFatores de riscoTransferases^i1^suso diagnóstEstudo de casos e controlesPetroleum industryOccupational exposure^i2^sadverse effeRisk factorsTransferases^i2^sdiagnosticCase-control studies OBJECTIVE: Occupational exposure typical of an oil refinery may alter liver function among the workers. Thus, the objective of the study was to identify risk factors for liver enzyme abnormalities among oil refinery workers. METHODS: The workers at an oil refinery in Northeastern Brazil underwent routine annual medical examination from 1982 to 1998. This case-control study investigated all the 150 cases of individuals with simultaneous gamma-glutamyltransferase and alanine aminotransferase abnormalities of at least 10% above reference levels. As controls, 150 workers without any liver enzyme or bilirubin abnormalities since starting to work there were selected. Odds ratios and the respective 95% confidence intervals were calculated from logistic regression models. RESULTS: In all the production sectors, the risk of liver enzyme abnormalities was significantly higher than in the administrative sector (OR=5.7; 95% CI: 1.7-18.4), even when the effects of alcohol, obesity and medical history of hepatitis were controlled for. During the period from 1992 to 1994, 88 out of the 89 cases occurred among workers from the various production sectors. CONCLUSIONS: Occupational exposure plays an important role in causing liver enzyme abnormalities among oil refinery workers. This is in addition to the specifically biological and/or behavioral risk factors such as obesity and alcohol consumption. OBJETIVO: A exposição ocupacional típica de uma refinaria de petróleo pode alterar a função hepática de seus trabalhadores. Assim, o objetivo do estudo foi identificar fatores de risco de alterações em enzimas hepáticas em trabalhadores de uma refinaria de petróleo. MÉTODOS: Os trabalhadores de uma refinaria de petróleo, localizada em São Francisco do Conde, Estado da Bahia, eram submetidos a exames periódicos anuais de 1982 a1998. O estudo caso-controle investigou todos os 150 casos de indivíduos com alteração simultânea de gama-glutamil transferase e de alanino amino transferase, de pelo menos 10% acima do valor de referência. Como controles, foram selecionados 150 indivíduos sem quaisquer alterações de enzimas hepáticas ou de bilirrubinas, desde a sua admissão. Foram calculadas as razões de chance e respectivos intervalos de confiança de 95% a partir de modelos de regressão logística. RESULTADOS: Em todos os setores de produção, o risco de alteração de enzimas hepáticas foi significantemente mais elevado do que no setor administrativo (RC=5,7; IC 95%: 1,7-18,4), estando controlados os efeitos do álcool, obesidade e antecedentes médicos de hepatite. No período 1992-1994 foram registrados 89 casos, 88 deles provieram dos diversos setores da produção. CONCLUSÕES: A exposição ocupacional desempenha papel importante na determinação de alterações de enzimas hepáticas em trabalhadores do refino de petróleo, além dos fatores de risco eminentemente biológicos e/ou comportamentais como obesidade e o consumo de álcool. Universidade de São Paulo. Faculdade de Saúde Pública2006-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/3198710.1590/S0034-89102006000100015Revista de Saúde Pública; Vol. 40 No. 1 (2006); 92-98 Revista de Saúde Pública; Vol. 40 Núm. 1 (2006); 92-98 Revista de Saúde Pública; v. 40 n. 1 (2006); 92-98 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporenghttps://www.revistas.usp.br/rsp/article/view/31987/33999https://www.revistas.usp.br/rsp/article/view/31987/34000Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessCarvalho, Fernando MartinsSilvany Neto, Annibal MunizMendes, João Luiz BarberinoCotrim, Helma PinchemelNascimento, Ana Lísia CunhaLima Júnior, Alberto SoaresCunha, Tatiana Oliveira Bernardo da2012-07-08T22:55:33Zoai:revistas.usp.br:article/31987Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-08T22:55:33Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Liver enzyme abnormalities among oil refinery workers Alteração de enzimas hepáticas em trabalhadores de refinaria de petróleo |
title |
Liver enzyme abnormalities among oil refinery workers |
spellingShingle |
Liver enzyme abnormalities among oil refinery workers Carvalho, Fernando Martins Indústria petroquímica Exposição ocupacional^i1^sefeitos adver Fatores de risco Transferases^i1^suso diagnóst Estudo de casos e controles Petroleum industry Occupational exposure^i2^sadverse effe Risk factors Transferases^i2^sdiagnostic Case-control studies |
title_short |
Liver enzyme abnormalities among oil refinery workers |
title_full |
Liver enzyme abnormalities among oil refinery workers |
title_fullStr |
Liver enzyme abnormalities among oil refinery workers |
title_full_unstemmed |
Liver enzyme abnormalities among oil refinery workers |
title_sort |
Liver enzyme abnormalities among oil refinery workers |
author |
Carvalho, Fernando Martins |
author_facet |
Carvalho, Fernando Martins Silvany Neto, Annibal Muniz Mendes, João Luiz Barberino Cotrim, Helma Pinchemel Nascimento, Ana Lísia Cunha Lima Júnior, Alberto Soares Cunha, Tatiana Oliveira Bernardo da |
author_role |
author |
author2 |
Silvany Neto, Annibal Muniz Mendes, João Luiz Barberino Cotrim, Helma Pinchemel Nascimento, Ana Lísia Cunha Lima Júnior, Alberto Soares Cunha, Tatiana Oliveira Bernardo da |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Carvalho, Fernando Martins Silvany Neto, Annibal Muniz Mendes, João Luiz Barberino Cotrim, Helma Pinchemel Nascimento, Ana Lísia Cunha Lima Júnior, Alberto Soares Cunha, Tatiana Oliveira Bernardo da |
dc.subject.por.fl_str_mv |
Indústria petroquímica Exposição ocupacional^i1^sefeitos adver Fatores de risco Transferases^i1^suso diagnóst Estudo de casos e controles Petroleum industry Occupational exposure^i2^sadverse effe Risk factors Transferases^i2^sdiagnostic Case-control studies |
topic |
Indústria petroquímica Exposição ocupacional^i1^sefeitos adver Fatores de risco Transferases^i1^suso diagnóst Estudo de casos e controles Petroleum industry Occupational exposure^i2^sadverse effe Risk factors Transferases^i2^sdiagnostic Case-control studies |
description |
OBJECTIVE: Occupational exposure typical of an oil refinery may alter liver function among the workers. Thus, the objective of the study was to identify risk factors for liver enzyme abnormalities among oil refinery workers. METHODS: The workers at an oil refinery in Northeastern Brazil underwent routine annual medical examination from 1982 to 1998. This case-control study investigated all the 150 cases of individuals with simultaneous gamma-glutamyltransferase and alanine aminotransferase abnormalities of at least 10% above reference levels. As controls, 150 workers without any liver enzyme or bilirubin abnormalities since starting to work there were selected. Odds ratios and the respective 95% confidence intervals were calculated from logistic regression models. RESULTS: In all the production sectors, the risk of liver enzyme abnormalities was significantly higher than in the administrative sector (OR=5.7; 95% CI: 1.7-18.4), even when the effects of alcohol, obesity and medical history of hepatitis were controlled for. During the period from 1992 to 1994, 88 out of the 89 cases occurred among workers from the various production sectors. CONCLUSIONS: Occupational exposure plays an important role in causing liver enzyme abnormalities among oil refinery workers. This is in addition to the specifically biological and/or behavioral risk factors such as obesity and alcohol consumption. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/31987 10.1590/S0034-89102006000100015 |
url |
https://www.revistas.usp.br/rsp/article/view/31987 |
identifier_str_mv |
10.1590/S0034-89102006000100015 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/31987/33999 https://www.revistas.usp.br/rsp/article/view/31987/34000 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista de Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista de Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 40 No. 1 (2006); 92-98 Revista de Saúde Pública; Vol. 40 Núm. 1 (2006); 92-98 Revista de Saúde Pública; v. 40 n. 1 (2006); 92-98 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1800221784485658624 |