Sensibility and speficity of the BCG scar reading
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/31580 |
Resumo: | OBJECTIVE: To validate the BCG scar as a marker of BCG vaccination status. METHODS: A cross-sectional survey was carried out among 53,348 schoolchildren aged 6-14 years who underwent BCG scar examination as part of a large BCG vaccine trial taking place in the city of Manaus, Brazil. Results of BCG scar reading were compared with information on vaccine status of their vaccination cards or provided by parents or guardians. Double-reading was performed in a sub-sample. Data analysis was conducted using Stata 7 and Kappa coefficient. RESULTS: Of 52,348 schoolchildren studied, vaccine status information from parents/guardian letters was available for 29,254 and from vaccination cards for 4,947. There was found a high agreement between the double-readings of the scars (Kappa=0.81). When the agreement between letter and card information was the gold standard, the sensitivity of BCG scar readings was 96.6% (95%CI 96.0-97.1) and the specificity was 71.1% (95%CI 55.7-83.7). The sensitivity was 96.1%, 97.3% and 95.3% for children vaccinated up to one month of age, four months and one year, respectively. CONCLUSIONS: Sensitivity and specificity did not show an association with the child's age at the scar reading. BCG scar was a good marker of BCG vaccination status regardless of age - from the first years of life up to 14 years old. |
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Sensibility and speficity of the BCG scar reading Sensibilidade e especificidade da leitura da cicatriz vacinal do BCG Vacina BCGVacinaçãoCicatrizReprodutibilidade de resultadosEstudos transversaisBCG vaccineVaccinationCicatrixReproducibility of resultsCross-sectional studies OBJECTIVE: To validate the BCG scar as a marker of BCG vaccination status. METHODS: A cross-sectional survey was carried out among 53,348 schoolchildren aged 6-14 years who underwent BCG scar examination as part of a large BCG vaccine trial taking place in the city of Manaus, Brazil. Results of BCG scar reading were compared with information on vaccine status of their vaccination cards or provided by parents or guardians. Double-reading was performed in a sub-sample. Data analysis was conducted using Stata 7 and Kappa coefficient. RESULTS: Of 52,348 schoolchildren studied, vaccine status information from parents/guardian letters was available for 29,254 and from vaccination cards for 4,947. There was found a high agreement between the double-readings of the scars (Kappa=0.81). When the agreement between letter and card information was the gold standard, the sensitivity of BCG scar readings was 96.6% (95%CI 96.0-97.1) and the specificity was 71.1% (95%CI 55.7-83.7). The sensitivity was 96.1%, 97.3% and 95.3% for children vaccinated up to one month of age, four months and one year, respectively. CONCLUSIONS: Sensitivity and specificity did not show an association with the child's age at the scar reading. BCG scar was a good marker of BCG vaccination status regardless of age - from the first years of life up to 14 years old. OBJETIVO: Validar a utilização da cicatriz vacinal de BCG como um indicador de vacinação. MÉTODOS: Foi realizado um estudo transversal em 52.348 escolares, entre 6 e 14 anos de idade, que possuíam exame de cicatriz vacinal do BCG e que participaram de um ensaio clínico randomizado e controlado na cidade de Manaus, Brasil. Os dados da leitura da cicatriz vacinal foram comparados com a informação sobre a vacinação passada fornecida pelos cartões vacinais ou informação dos responsáveis. Em uma subamostra foi realizada leitura dupla com cálculo do coeficiente Kappa. Para análise dos dados utilizou-se o Stata 7. RESULTADOS: Do total de 52.348 escolares estudados, 29.254 possuíam informação sobre cicatriz vacinal coletada por meio de carta aos pais, e 4.947 possuíam história de vacinação coletada pelo cartão de vacinas. Observou-se elevada concordância entre a dupla leitura de cicatriz vacinal (Kappa =0,81). A sensibilidade da leitura de cicatriz vacinal foi 96,6% (95% IC 96,0-97,1) e a especificidade foi 71,1% (95% IC 55,7-83,7) quando o padrão ouro utilizado foi a concordância entre a carta aos pais e a informação do cartão de vacinas. A sensibilidade foi de 96,1%, 97,3% e 95,3% para crianças vacinadas até um mês de idade, até 4 meses e até um ano de idade, respectivamente. CONCLUSÕES: Os valores encontrados para sensibilidade e especificidade foram independentes da idade da realização da leitura de cicatriz vacinal. O exame da cicatriz vacinal mostrou ser um bom indicador para avaliar a situação vacinal referente ao BCG. Universidade de São Paulo. Faculdade de Saúde Pública2003-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/3158010.1590/S0034-89102003000200015Revista de Saúde Pública; Vol. 37 No. 2 (2003); 254-259 Revista de Saúde Pública; Vol. 37 Núm. 2 (2003); 254-259 Revista de Saúde Pública; v. 37 n. 2 (2003); 254-259 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/31580/33465Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessPereira, Susan MBierrenbach, Ana LDourado, InêsBarreto, Maurício LIchihara, Maria YuryHijjar, Miguel ARodrigues, L C2012-07-08T14:53:34Zoai:revistas.usp.br:article/31580Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-08T14:53:34Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Sensibility and speficity of the BCG scar reading Sensibilidade e especificidade da leitura da cicatriz vacinal do BCG |
title |
Sensibility and speficity of the BCG scar reading |
spellingShingle |
Sensibility and speficity of the BCG scar reading Pereira, Susan M Vacina BCG Vacinação Cicatriz Reprodutibilidade de resultados Estudos transversais BCG vaccine Vaccination Cicatrix Reproducibility of results Cross-sectional studies |
title_short |
Sensibility and speficity of the BCG scar reading |
title_full |
Sensibility and speficity of the BCG scar reading |
title_fullStr |
Sensibility and speficity of the BCG scar reading |
title_full_unstemmed |
Sensibility and speficity of the BCG scar reading |
title_sort |
Sensibility and speficity of the BCG scar reading |
author |
Pereira, Susan M |
author_facet |
Pereira, Susan M Bierrenbach, Ana L Dourado, Inês Barreto, Maurício L Ichihara, Maria Yury Hijjar, Miguel A Rodrigues, L C |
author_role |
author |
author2 |
Bierrenbach, Ana L Dourado, Inês Barreto, Maurício L Ichihara, Maria Yury Hijjar, Miguel A Rodrigues, L C |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira, Susan M Bierrenbach, Ana L Dourado, Inês Barreto, Maurício L Ichihara, Maria Yury Hijjar, Miguel A Rodrigues, L C |
dc.subject.por.fl_str_mv |
Vacina BCG Vacinação Cicatriz Reprodutibilidade de resultados Estudos transversais BCG vaccine Vaccination Cicatrix Reproducibility of results Cross-sectional studies |
topic |
Vacina BCG Vacinação Cicatriz Reprodutibilidade de resultados Estudos transversais BCG vaccine Vaccination Cicatrix Reproducibility of results Cross-sectional studies |
description |
OBJECTIVE: To validate the BCG scar as a marker of BCG vaccination status. METHODS: A cross-sectional survey was carried out among 53,348 schoolchildren aged 6-14 years who underwent BCG scar examination as part of a large BCG vaccine trial taking place in the city of Manaus, Brazil. Results of BCG scar reading were compared with information on vaccine status of their vaccination cards or provided by parents or guardians. Double-reading was performed in a sub-sample. Data analysis was conducted using Stata 7 and Kappa coefficient. RESULTS: Of 52,348 schoolchildren studied, vaccine status information from parents/guardian letters was available for 29,254 and from vaccination cards for 4,947. There was found a high agreement between the double-readings of the scars (Kappa=0.81). When the agreement between letter and card information was the gold standard, the sensitivity of BCG scar readings was 96.6% (95%CI 96.0-97.1) and the specificity was 71.1% (95%CI 55.7-83.7). The sensitivity was 96.1%, 97.3% and 95.3% for children vaccinated up to one month of age, four months and one year, respectively. CONCLUSIONS: Sensitivity and specificity did not show an association with the child's age at the scar reading. BCG scar was a good marker of BCG vaccination status regardless of age - from the first years of life up to 14 years old. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/31580 10.1590/S0034-89102003000200015 |
url |
https://www.revistas.usp.br/rsp/article/view/31580 |
identifier_str_mv |
10.1590/S0034-89102003000200015 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/31580/33465 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista de Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista de Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 37 No. 2 (2003); 254-259 Revista de Saúde Pública; Vol. 37 Núm. 2 (2003); 254-259 Revista de Saúde Pública; v. 37 n. 2 (2003); 254-259 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1800221781249753088 |