Sensibility and speficity of the BCG scar reading

Detalhes bibliográficos
Autor(a) principal: Pereira, Susan M
Data de Publicação: 2003
Outros Autores: Bierrenbach, Ana L, Dourado, Inês, Barreto, Maurício L, Ichihara, Maria Yury, Hijjar, Miguel A, Rodrigues, L C
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/31580
Resumo: OBJECTIVE: To validate the BCG scar as a marker of BCG vaccination status. METHODS: A cross-sectional survey was carried out among 53,348 schoolchildren aged 6-14 years who underwent BCG scar examination as part of a large BCG vaccine trial taking place in the city of Manaus, Brazil. Results of BCG scar reading were compared with information on vaccine status of their vaccination cards or provided by parents or guardians. Double-reading was performed in a sub-sample. Data analysis was conducted using Stata 7 and Kappa coefficient. RESULTS: Of 52,348 schoolchildren studied, vaccine status information from parents/guardian letters was available for 29,254 and from vaccination cards for 4,947. There was found a high agreement between the double-readings of the scars (Kappa=0.81). When the agreement between letter and card information was the gold standard, the sensitivity of BCG scar readings was 96.6% (95%CI 96.0-97.1) and the specificity was 71.1% (95%CI 55.7-83.7). The sensitivity was 96.1%, 97.3% and 95.3% for children vaccinated up to one month of age, four months and one year, respectively. CONCLUSIONS: Sensitivity and specificity did not show an association with the child's age at the scar reading. BCG scar was a good marker of BCG vaccination status regardless of age - from the first years of life up to 14 years old.
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spelling Sensibility and speficity of the BCG scar reading Sensibilidade e especificidade da leitura da cicatriz vacinal do BCG Vacina BCGVacinaçãoCicatrizReprodutibilidade de resultadosEstudos transversaisBCG vaccineVaccinationCicatrixReproducibility of resultsCross-sectional studies OBJECTIVE: To validate the BCG scar as a marker of BCG vaccination status. METHODS: A cross-sectional survey was carried out among 53,348 schoolchildren aged 6-14 years who underwent BCG scar examination as part of a large BCG vaccine trial taking place in the city of Manaus, Brazil. Results of BCG scar reading were compared with information on vaccine status of their vaccination cards or provided by parents or guardians. Double-reading was performed in a sub-sample. Data analysis was conducted using Stata 7 and Kappa coefficient. RESULTS: Of 52,348 schoolchildren studied, vaccine status information from parents/guardian letters was available for 29,254 and from vaccination cards for 4,947. There was found a high agreement between the double-readings of the scars (Kappa=0.81). When the agreement between letter and card information was the gold standard, the sensitivity of BCG scar readings was 96.6% (95%CI 96.0-97.1) and the specificity was 71.1% (95%CI 55.7-83.7). The sensitivity was 96.1%, 97.3% and 95.3% for children vaccinated up to one month of age, four months and one year, respectively. CONCLUSIONS: Sensitivity and specificity did not show an association with the child's age at the scar reading. BCG scar was a good marker of BCG vaccination status regardless of age - from the first years of life up to 14 years old. OBJETIVO: Validar a utilização da cicatriz vacinal de BCG como um indicador de vacinação. MÉTODOS: Foi realizado um estudo transversal em 52.348 escolares, entre 6 e 14 anos de idade, que possuíam exame de cicatriz vacinal do BCG e que participaram de um ensaio clínico randomizado e controlado na cidade de Manaus, Brasil. Os dados da leitura da cicatriz vacinal foram comparados com a informação sobre a vacinação passada fornecida pelos cartões vacinais ou informação dos responsáveis. Em uma subamostra foi realizada leitura dupla com cálculo do coeficiente Kappa. Para análise dos dados utilizou-se o Stata 7. RESULTADOS: Do total de 52.348 escolares estudados, 29.254 possuíam informação sobre cicatriz vacinal coletada por meio de carta aos pais, e 4.947 possuíam história de vacinação coletada pelo cartão de vacinas. Observou-se elevada concordância entre a dupla leitura de cicatriz vacinal (Kappa =0,81). A sensibilidade da leitura de cicatriz vacinal foi 96,6% (95% IC 96,0-97,1) e a especificidade foi 71,1% (95% IC 55,7-83,7) quando o padrão ouro utilizado foi a concordância entre a carta aos pais e a informação do cartão de vacinas. A sensibilidade foi de 96,1%, 97,3% e 95,3% para crianças vacinadas até um mês de idade, até 4 meses e até um ano de idade, respectivamente. CONCLUSÕES: Os valores encontrados para sensibilidade e especificidade foram independentes da idade da realização da leitura de cicatriz vacinal. O exame da cicatriz vacinal mostrou ser um bom indicador para avaliar a situação vacinal referente ao BCG. Universidade de São Paulo. Faculdade de Saúde Pública2003-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/3158010.1590/S0034-89102003000200015Revista de Saúde Pública; Vol. 37 No. 2 (2003); 254-259 Revista de Saúde Pública; Vol. 37 Núm. 2 (2003); 254-259 Revista de Saúde Pública; v. 37 n. 2 (2003); 254-259 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/31580/33465Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessPereira, Susan MBierrenbach, Ana LDourado, InêsBarreto, Maurício LIchihara, Maria YuryHijjar, Miguel ARodrigues, L C2012-07-08T14:53:34Zoai:revistas.usp.br:article/31580Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-08T14:53:34Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Sensibility and speficity of the BCG scar reading
Sensibilidade e especificidade da leitura da cicatriz vacinal do BCG
title Sensibility and speficity of the BCG scar reading
spellingShingle Sensibility and speficity of the BCG scar reading
Pereira, Susan M
Vacina BCG
Vacinação
Cicatriz
Reprodutibilidade de resultados
Estudos transversais
BCG vaccine
Vaccination
Cicatrix
Reproducibility of results
Cross-sectional studies
title_short Sensibility and speficity of the BCG scar reading
title_full Sensibility and speficity of the BCG scar reading
title_fullStr Sensibility and speficity of the BCG scar reading
title_full_unstemmed Sensibility and speficity of the BCG scar reading
title_sort Sensibility and speficity of the BCG scar reading
author Pereira, Susan M
author_facet Pereira, Susan M
Bierrenbach, Ana L
Dourado, Inês
Barreto, Maurício L
Ichihara, Maria Yury
Hijjar, Miguel A
Rodrigues, L C
author_role author
author2 Bierrenbach, Ana L
Dourado, Inês
Barreto, Maurício L
Ichihara, Maria Yury
Hijjar, Miguel A
Rodrigues, L C
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Susan M
Bierrenbach, Ana L
Dourado, Inês
Barreto, Maurício L
Ichihara, Maria Yury
Hijjar, Miguel A
Rodrigues, L C
dc.subject.por.fl_str_mv Vacina BCG
Vacinação
Cicatriz
Reprodutibilidade de resultados
Estudos transversais
BCG vaccine
Vaccination
Cicatrix
Reproducibility of results
Cross-sectional studies
topic Vacina BCG
Vacinação
Cicatriz
Reprodutibilidade de resultados
Estudos transversais
BCG vaccine
Vaccination
Cicatrix
Reproducibility of results
Cross-sectional studies
description OBJECTIVE: To validate the BCG scar as a marker of BCG vaccination status. METHODS: A cross-sectional survey was carried out among 53,348 schoolchildren aged 6-14 years who underwent BCG scar examination as part of a large BCG vaccine trial taking place in the city of Manaus, Brazil. Results of BCG scar reading were compared with information on vaccine status of their vaccination cards or provided by parents or guardians. Double-reading was performed in a sub-sample. Data analysis was conducted using Stata 7 and Kappa coefficient. RESULTS: Of 52,348 schoolchildren studied, vaccine status information from parents/guardian letters was available for 29,254 and from vaccination cards for 4,947. There was found a high agreement between the double-readings of the scars (Kappa=0.81). When the agreement between letter and card information was the gold standard, the sensitivity of BCG scar readings was 96.6% (95%CI 96.0-97.1) and the specificity was 71.1% (95%CI 55.7-83.7). The sensitivity was 96.1%, 97.3% and 95.3% for children vaccinated up to one month of age, four months and one year, respectively. CONCLUSIONS: Sensitivity and specificity did not show an association with the child's age at the scar reading. BCG scar was a good marker of BCG vaccination status regardless of age - from the first years of life up to 14 years old.
publishDate 2003
dc.date.none.fl_str_mv 2003-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/31580
10.1590/S0034-89102003000200015
url https://www.revistas.usp.br/rsp/article/view/31580
identifier_str_mv 10.1590/S0034-89102003000200015
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/31580/33465
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 37 No. 2 (2003); 254-259
Revista de Saúde Pública; Vol. 37 Núm. 2 (2003); 254-259
Revista de Saúde Pública; v. 37 n. 2 (2003); 254-259
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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