Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil

Detalhes bibliográficos
Autor(a) principal: Guerra Júnior,Augusto Afonso
Data de Publicação: 2015
Outros Autores: Silva,Grazielle Dias, Andrade,Eli Iola Gurgel, Cherchiglia,Mariângela Leal, Costa,Juliana de Oliveira, Almeida,Alessandra Maciel, Acurcio,Francisco de Assis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Saúde Pública
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102015000100209
Resumo: OBJECTIVE To analyze the cost-effectiveness of treatment regimens with cyclosporine or tacrolimus, five years after renal transplantation.METHODS This cost-effectiveness analysis was based on historical cohort data obtained between 2000 and 2004 and involved 2,022 patients treated with cyclosporine or tacrolimus, matched 1:1 for gender, age, and type and year of transplantation. Graft survival and the direct costs of medical care obtained from the National Health System (SUS) databases were used as outcome results.RESULTS Most of the patients were women, with a mean age of 36.6 years. The most frequent diagnosis of chronic renal failure was glomerulonephritis/nephritis (27.7%). In five years, the tacrolimus group had an average life expectancy gain of 3.96 years at an annual cost of R$78,360.57 compared with the cyclosporine group with a gain of 4.05 years and an annual cost of R$61,350.44.CONCLUSIONS After matching, the study indicated better survival of patients treated with regimens using tacrolimus. However, regimens containing cyclosporine were more cost-effective.
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spelling Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in BrazilImmunosuppressive Agentstherapeutic useKidney TransplantationeconomicsGraft SurvivalTransplantation Tolerancedrug effectsCost-Benefit AnalysisUnified Health SystemCohort StudiesOBJECTIVE To analyze the cost-effectiveness of treatment regimens with cyclosporine or tacrolimus, five years after renal transplantation.METHODS This cost-effectiveness analysis was based on historical cohort data obtained between 2000 and 2004 and involved 2,022 patients treated with cyclosporine or tacrolimus, matched 1:1 for gender, age, and type and year of transplantation. Graft survival and the direct costs of medical care obtained from the National Health System (SUS) databases were used as outcome results.RESULTS Most of the patients were women, with a mean age of 36.6 years. The most frequent diagnosis of chronic renal failure was glomerulonephritis/nephritis (27.7%). In five years, the tacrolimus group had an average life expectancy gain of 3.96 years at an annual cost of R$78,360.57 compared with the cyclosporine group with a gain of 4.05 years and an annual cost of R$61,350.44.CONCLUSIONS After matching, the study indicated better survival of patients treated with regimens using tacrolimus. However, regimens containing cyclosporine were more cost-effective.Faculdade de Saúde Pública da Universidade de São Paulo2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102015000100209Revista de Saúde Pública v.49 2015reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0034-8910.2015049005430info:eu-repo/semantics/openAccessGuerra Júnior,Augusto AfonsoSilva,Grazielle DiasAndrade,Eli Iola GurgelCherchiglia,Mariângela LealCosta,Juliana de OliveiraAlmeida,Alessandra MacielAcurcio,Francisco de Assiseng2015-10-28T00:00:00Zoai:scielo:S0034-89102015000100209Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0034-8910&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.phprevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2015-10-28T00:00Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil
title Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil
spellingShingle Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil
Guerra Júnior,Augusto Afonso
Immunosuppressive Agents
therapeutic use
Kidney Transplantation
economics
Graft Survival
Transplantation Tolerance
drug effects
Cost-Benefit Analysis
Unified Health System
Cohort Studies
title_short Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil
title_full Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil
title_fullStr Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil
title_full_unstemmed Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil
title_sort Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil
author Guerra Júnior,Augusto Afonso
author_facet Guerra Júnior,Augusto Afonso
Silva,Grazielle Dias
Andrade,Eli Iola Gurgel
Cherchiglia,Mariângela Leal
Costa,Juliana de Oliveira
Almeida,Alessandra Maciel
Acurcio,Francisco de Assis
author_role author
author2 Silva,Grazielle Dias
Andrade,Eli Iola Gurgel
Cherchiglia,Mariângela Leal
Costa,Juliana de Oliveira
Almeida,Alessandra Maciel
Acurcio,Francisco de Assis
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Guerra Júnior,Augusto Afonso
Silva,Grazielle Dias
Andrade,Eli Iola Gurgel
Cherchiglia,Mariângela Leal
Costa,Juliana de Oliveira
Almeida,Alessandra Maciel
Acurcio,Francisco de Assis
dc.subject.por.fl_str_mv Immunosuppressive Agents
therapeutic use
Kidney Transplantation
economics
Graft Survival
Transplantation Tolerance
drug effects
Cost-Benefit Analysis
Unified Health System
Cohort Studies
topic Immunosuppressive Agents
therapeutic use
Kidney Transplantation
economics
Graft Survival
Transplantation Tolerance
drug effects
Cost-Benefit Analysis
Unified Health System
Cohort Studies
description OBJECTIVE To analyze the cost-effectiveness of treatment regimens with cyclosporine or tacrolimus, five years after renal transplantation.METHODS This cost-effectiveness analysis was based on historical cohort data obtained between 2000 and 2004 and involved 2,022 patients treated with cyclosporine or tacrolimus, matched 1:1 for gender, age, and type and year of transplantation. Graft survival and the direct costs of medical care obtained from the National Health System (SUS) databases were used as outcome results.RESULTS Most of the patients were women, with a mean age of 36.6 years. The most frequent diagnosis of chronic renal failure was glomerulonephritis/nephritis (27.7%). In five years, the tacrolimus group had an average life expectancy gain of 3.96 years at an annual cost of R$78,360.57 compared with the cyclosporine group with a gain of 4.05 years and an annual cost of R$61,350.44.CONCLUSIONS After matching, the study indicated better survival of patients treated with regimens using tacrolimus. However, regimens containing cyclosporine were more cost-effective.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102015000100209
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0034-8910.2015049005430
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dc.publisher.none.fl_str_mv Faculdade de Saúde Pública da Universidade de São Paulo
publisher.none.fl_str_mv Faculdade de Saúde Pública da Universidade de São Paulo
dc.source.none.fl_str_mv Revista de Saúde Pública v.49 2015
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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