Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102015000100209 |
Resumo: | OBJECTIVE To analyze the cost-effectiveness of treatment regimens with cyclosporine or tacrolimus, five years after renal transplantation.METHODS This cost-effectiveness analysis was based on historical cohort data obtained between 2000 and 2004 and involved 2,022 patients treated with cyclosporine or tacrolimus, matched 1:1 for gender, age, and type and year of transplantation. Graft survival and the direct costs of medical care obtained from the National Health System (SUS) databases were used as outcome results.RESULTS Most of the patients were women, with a mean age of 36.6 years. The most frequent diagnosis of chronic renal failure was glomerulonephritis/nephritis (27.7%). In five years, the tacrolimus group had an average life expectancy gain of 3.96 years at an annual cost of R$78,360.57 compared with the cyclosporine group with a gain of 4.05 years and an annual cost of R$61,350.44.CONCLUSIONS After matching, the study indicated better survival of patients treated with regimens using tacrolimus. However, regimens containing cyclosporine were more cost-effective. |
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Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in BrazilImmunosuppressive Agentstherapeutic useKidney TransplantationeconomicsGraft SurvivalTransplantation Tolerancedrug effectsCost-Benefit AnalysisUnified Health SystemCohort StudiesOBJECTIVE To analyze the cost-effectiveness of treatment regimens with cyclosporine or tacrolimus, five years after renal transplantation.METHODS This cost-effectiveness analysis was based on historical cohort data obtained between 2000 and 2004 and involved 2,022 patients treated with cyclosporine or tacrolimus, matched 1:1 for gender, age, and type and year of transplantation. Graft survival and the direct costs of medical care obtained from the National Health System (SUS) databases were used as outcome results.RESULTS Most of the patients were women, with a mean age of 36.6 years. The most frequent diagnosis of chronic renal failure was glomerulonephritis/nephritis (27.7%). In five years, the tacrolimus group had an average life expectancy gain of 3.96 years at an annual cost of R$78,360.57 compared with the cyclosporine group with a gain of 4.05 years and an annual cost of R$61,350.44.CONCLUSIONS After matching, the study indicated better survival of patients treated with regimens using tacrolimus. However, regimens containing cyclosporine were more cost-effective.Faculdade de Saúde Pública da Universidade de São Paulo2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102015000100209Revista de Saúde Pública v.49 2015reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0034-8910.2015049005430info:eu-repo/semantics/openAccessGuerra Júnior,Augusto AfonsoSilva,Grazielle DiasAndrade,Eli Iola GurgelCherchiglia,Mariângela LealCosta,Juliana de OliveiraAlmeida,Alessandra MacielAcurcio,Francisco de Assiseng2015-10-28T00:00:00Zoai:scielo:S0034-89102015000100209Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0034-8910&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.phprevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2015-10-28T00:00Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil |
title |
Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil |
spellingShingle |
Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil Guerra Júnior,Augusto Afonso Immunosuppressive Agents therapeutic use Kidney Transplantation economics Graft Survival Transplantation Tolerance drug effects Cost-Benefit Analysis Unified Health System Cohort Studies |
title_short |
Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil |
title_full |
Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil |
title_fullStr |
Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil |
title_full_unstemmed |
Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil |
title_sort |
Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil |
author |
Guerra Júnior,Augusto Afonso |
author_facet |
Guerra Júnior,Augusto Afonso Silva,Grazielle Dias Andrade,Eli Iola Gurgel Cherchiglia,Mariângela Leal Costa,Juliana de Oliveira Almeida,Alessandra Maciel Acurcio,Francisco de Assis |
author_role |
author |
author2 |
Silva,Grazielle Dias Andrade,Eli Iola Gurgel Cherchiglia,Mariângela Leal Costa,Juliana de Oliveira Almeida,Alessandra Maciel Acurcio,Francisco de Assis |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Guerra Júnior,Augusto Afonso Silva,Grazielle Dias Andrade,Eli Iola Gurgel Cherchiglia,Mariângela Leal Costa,Juliana de Oliveira Almeida,Alessandra Maciel Acurcio,Francisco de Assis |
dc.subject.por.fl_str_mv |
Immunosuppressive Agents therapeutic use Kidney Transplantation economics Graft Survival Transplantation Tolerance drug effects Cost-Benefit Analysis Unified Health System Cohort Studies |
topic |
Immunosuppressive Agents therapeutic use Kidney Transplantation economics Graft Survival Transplantation Tolerance drug effects Cost-Benefit Analysis Unified Health System Cohort Studies |
description |
OBJECTIVE To analyze the cost-effectiveness of treatment regimens with cyclosporine or tacrolimus, five years after renal transplantation.METHODS This cost-effectiveness analysis was based on historical cohort data obtained between 2000 and 2004 and involved 2,022 patients treated with cyclosporine or tacrolimus, matched 1:1 for gender, age, and type and year of transplantation. Graft survival and the direct costs of medical care obtained from the National Health System (SUS) databases were used as outcome results.RESULTS Most of the patients were women, with a mean age of 36.6 years. The most frequent diagnosis of chronic renal failure was glomerulonephritis/nephritis (27.7%). In five years, the tacrolimus group had an average life expectancy gain of 3.96 years at an annual cost of R$78,360.57 compared with the cyclosporine group with a gain of 4.05 years and an annual cost of R$61,350.44.CONCLUSIONS After matching, the study indicated better survival of patients treated with regimens using tacrolimus. However, regimens containing cyclosporine were more cost-effective. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102015000100209 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102015000100209 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0034-8910.2015049005430 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade de Saúde Pública da Universidade de São Paulo |
publisher.none.fl_str_mv |
Faculdade de Saúde Pública da Universidade de São Paulo |
dc.source.none.fl_str_mv |
Revista de Saúde Pública v.49 2015 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1748936502874734592 |