A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS

Detalhes bibliográficos
Autor(a) principal: Coutinho,FAB
Data de Publicação: 1999
Outros Autores: Massad,E, Menezes,RX, Burattini,MN
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Saúde Pública
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89101999000400002
Resumo: INTRODUCTION: The evolution of virulence in host-parasite relationships has been the subject of several publications. In the case of HIV virulence, some authors suggest that the evolution of HIV virulence correlates with the rate of acquisition of new sexual partners. In contrast some other authors argue that the level of HIV virulence is independent of the sexual activity of the host population. METHODS: Provide a mathematical model for the study of the potential influence of human sexual behaviour on the evolution of virulence of HIV is provided. RESULTS: The results indicated that, when the probability of acquisition of infection is a function both of the sexual activity and of the virulence level of HIV strains, the evolution of HIV virulence correlates positively with the rate of acquisition of new sexual partners. CONCLUSION: It is concluded that in the case of a host population with a low (high) rate of exchange of sexual partners the evolution of HIV virulence is such that the less (more) virulent strain prevails.
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spelling A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDSAcquired Inmunodeficiency SyndromeVirulenceModels, statisticalINTRODUCTION: The evolution of virulence in host-parasite relationships has been the subject of several publications. In the case of HIV virulence, some authors suggest that the evolution of HIV virulence correlates with the rate of acquisition of new sexual partners. In contrast some other authors argue that the level of HIV virulence is independent of the sexual activity of the host population. METHODS: Provide a mathematical model for the study of the potential influence of human sexual behaviour on the evolution of virulence of HIV is provided. RESULTS: The results indicated that, when the probability of acquisition of infection is a function both of the sexual activity and of the virulence level of HIV strains, the evolution of HIV virulence correlates positively with the rate of acquisition of new sexual partners. CONCLUSION: It is concluded that in the case of a host population with a low (high) rate of exchange of sexual partners the evolution of HIV virulence is such that the less (more) virulent strain prevails.Faculdade de Saúde Pública da Universidade de São Paulo1999-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89101999000400002Revista de Saúde Pública v.33 n.4 1999reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0034-89101999000400002info:eu-repo/semantics/openAccessCoutinho,FABMassad,EMenezes,RXBurattini,MNeng2001-08-07T00:00:00Zoai:scielo:S0034-89101999000400002Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0034-8910&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.phprevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2001-08-07T00:00Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS
title A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS
spellingShingle A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS
Coutinho,FAB
Acquired Inmunodeficiency Syndrome
Virulence
Models, statistical
title_short A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS
title_full A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS
title_fullStr A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS
title_full_unstemmed A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS
title_sort A theoretical model of the evolution of virulence in sexually transmitted HIV/AIDS
author Coutinho,FAB
author_facet Coutinho,FAB
Massad,E
Menezes,RX
Burattini,MN
author_role author
author2 Massad,E
Menezes,RX
Burattini,MN
author2_role author
author
author
dc.contributor.author.fl_str_mv Coutinho,FAB
Massad,E
Menezes,RX
Burattini,MN
dc.subject.por.fl_str_mv Acquired Inmunodeficiency Syndrome
Virulence
Models, statistical
topic Acquired Inmunodeficiency Syndrome
Virulence
Models, statistical
description INTRODUCTION: The evolution of virulence in host-parasite relationships has been the subject of several publications. In the case of HIV virulence, some authors suggest that the evolution of HIV virulence correlates with the rate of acquisition of new sexual partners. In contrast some other authors argue that the level of HIV virulence is independent of the sexual activity of the host population. METHODS: Provide a mathematical model for the study of the potential influence of human sexual behaviour on the evolution of virulence of HIV is provided. RESULTS: The results indicated that, when the probability of acquisition of infection is a function both of the sexual activity and of the virulence level of HIV strains, the evolution of HIV virulence correlates positively with the rate of acquisition of new sexual partners. CONCLUSION: It is concluded that in the case of a host population with a low (high) rate of exchange of sexual partners the evolution of HIV virulence is such that the less (more) virulent strain prevails.
publishDate 1999
dc.date.none.fl_str_mv 1999-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89101999000400002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89101999000400002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0034-89101999000400002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade de Saúde Pública da Universidade de São Paulo
publisher.none.fl_str_mv Faculdade de Saúde Pública da Universidade de São Paulo
dc.source.none.fl_str_mv Revista de Saúde Pública v.33 n.4 1999
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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