Oral clefts: a case-control study

• Autor(a) principal: Loffredo, Leonor de Castro Monteiro
• Data de Publicação: 1994
• Outros Autores: Souza, José Maria Pacheco de, Yunes, João, Freitas, José Alberto de Souza, Spiri, Wilza Carla
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista de Saúde Pública
• Texto Completo: https://www.revistas.usp.br/rsp/article/view/24036
• topic: Lábio leporino^i1^sepidemiolo; Fissura palatina^i1^sepidemiolo; Fatores de risco; Cleft lip^i2^sepidemiol; Cleft palate^i2^sepidemiol; Risk factors

This study relates to a case-control analysis for the purpose of verifying the association between oral clefts and possible risk factors. The analysed variables were: place of mother's residence (urban/ rural), pollution, parental diseases, mother's diseases during the first four months of pregnancy, intake of drugs related to this period, heredity, smoking habits, alcohol consumption and X-ray examinations during pregnancy or X-ray examinations prior to preganacy. There were 450 cases of clefts of whom 354 had a cleft lip with or without cleft palate and 96 had a cleft palate. The relative risk (RR) for each variable by was estimated points and at a 95% of confidence interval and multivariate analysis was applied. As regards cleft lip with or without cleft palate, the risk factors are heredity (RR = 4.96), epilepsy in the mother (RR = 2.39) and the intake of drugs such as anti-inflammatory substance in the first four months of pregnancy (RR = 2.59). Related to cleft palate, the risk factors are heredity (RR = 2.82) and pollution (RR = 2.58).