Humoral immune response of dogs to the inactivated suckling mouse brain vaccine utilized in anti-rabies campaigns in Brazil
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/24317 |
Resumo: | INTRODUCTION: An anti-rabies campaign is undertaken annually in Brazil with of the Fuenzalida & Palacios vaccine. The humoral immune response of dogs vaccinated during the campaigns was researched with the objective of evaluating whether the dogs presented a protective titer (0.5 UI/ml) 12 months after vaccination and how many of these achieved this titer 30 days after a buttressing vaccination. MATERIAL AND METHOD: Three hundred and forty-one specimens of serum of dogs domicilied, 259 in the S. Paulo and 82 in the Paulinia counties, were analyzed utilizing the Rapid Fluorescence Focus Inhibition Test. The immune response was evaluated taking into consideration the nutritional state of the animal and the number of previous vaccinations. RESULTS: The larger number of the dogs had not achieved the 0.5 UI/ml titer after 12 months, independently of the nutritional state and the response to the buttressing vaccination was more apparent in dogs with two or more previous vaccinations. DISCUSSION: The cut off of 0.5 Ul/ml as protective titer in dogs and the influence of the nutritional state and health conditions of the animals as responsible for humoral immune response are discussed. |
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Humoral immune response of dogs to the inactivated suckling mouse brain vaccine utilized in anti-rabies campaigns in Brazil Resposta imune humoral de cães à vacina inativada, de cérebro de camundongos lactentes, utilizada nas campanhas anti-rábicas no Brasil Vacina anti-rábica^i1^simunoloRelação dose-resposta imunológicaRabies vaccineDose-response relationship^i2^simmunolo INTRODUCTION: An anti-rabies campaign is undertaken annually in Brazil with of the Fuenzalida & Palacios vaccine. The humoral immune response of dogs vaccinated during the campaigns was researched with the objective of evaluating whether the dogs presented a protective titer (0.5 UI/ml) 12 months after vaccination and how many of these achieved this titer 30 days after a buttressing vaccination. MATERIAL AND METHOD: Three hundred and forty-one specimens of serum of dogs domicilied, 259 in the S. Paulo and 82 in the Paulinia counties, were analyzed utilizing the Rapid Fluorescence Focus Inhibition Test. The immune response was evaluated taking into consideration the nutritional state of the animal and the number of previous vaccinations. RESULTS: The larger number of the dogs had not achieved the 0.5 UI/ml titer after 12 months, independently of the nutritional state and the response to the buttressing vaccination was more apparent in dogs with two or more previous vaccinations. DISCUSSION: The cut off of 0.5 Ul/ml as protective titer in dogs and the influence of the nutritional state and health conditions of the animals as responsible for humoral immune response are discussed. INTRODUÇÃO: A campanha anti-rábica no Brasil é realizada anualmente utilizando a vacina de cérebro de camundongos lactentes Fuenzalida-Palacios. A resposta imune humoral de cães vacinados durante as campanhas foi analisada objetivando avaliar se os cães apresentavam título protetor (0,5 UI/ml), 12 meses após a vacinação, e quantos deles alcançam esse título 30 dias após o reforço vacinal. MATERIAL E MÉTODO: Foram analisadas 341 amostras de soro de cães domiciliados (259 do Município de São Paulo e 82 do Município de Paulínia), através da Técnica de Inibição de Focos de Fluorescência Rápida. A resposta imune foi avaliada considerando o estado nutricional do animal e o número de vacinações anteriores. RESULTADO: A maioria dos cães não tinha título de 0,5 UI/ml após 12 meses, independentemente do estado nutricional, e a resposta humoral ao reforço vacinal mostrou-se melhor em cães com duas ou mais vacinações prévias. DISCUSSÃO: São discutidos o referencial de 0,5 Ul/ml como título protetor para a espécie canina e a influência do estado nutricional e condição de saúde do animal como responsável pela resposta imune humoral. Universidade de São Paulo. Faculdade de Saúde Pública1997-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/2431710.1590/S0034-89101997000600009Revista de Saúde Pública; Vol. 31 No. 5 (1997); 502-507 Revista de Saúde Pública; Vol. 31 Núm. 5 (1997); 502-507 Revista de Saúde Pública; v. 31 n. 5 (1997); 502-507 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/24317/26241Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessAlmeida, Marilene F.Aguiar, Elizabeth A. C.Martorelli, Luzia A. F.Presotto, DouglasBrandão, Marcelo M.Pereira, Octávio A. C.2012-05-29T16:51:32Zoai:revistas.usp.br:article/24317Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-05-29T16:51:32Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Humoral immune response of dogs to the inactivated suckling mouse brain vaccine utilized in anti-rabies campaigns in Brazil Resposta imune humoral de cães à vacina inativada, de cérebro de camundongos lactentes, utilizada nas campanhas anti-rábicas no Brasil |
title |
Humoral immune response of dogs to the inactivated suckling mouse brain vaccine utilized in anti-rabies campaigns in Brazil |
spellingShingle |
Humoral immune response of dogs to the inactivated suckling mouse brain vaccine utilized in anti-rabies campaigns in Brazil Almeida, Marilene F. Vacina anti-rábica^i1^simunolo Relação dose-resposta imunológica Rabies vaccine Dose-response relationship^i2^simmunolo |
title_short |
Humoral immune response of dogs to the inactivated suckling mouse brain vaccine utilized in anti-rabies campaigns in Brazil |
title_full |
Humoral immune response of dogs to the inactivated suckling mouse brain vaccine utilized in anti-rabies campaigns in Brazil |
title_fullStr |
Humoral immune response of dogs to the inactivated suckling mouse brain vaccine utilized in anti-rabies campaigns in Brazil |
title_full_unstemmed |
Humoral immune response of dogs to the inactivated suckling mouse brain vaccine utilized in anti-rabies campaigns in Brazil |
title_sort |
Humoral immune response of dogs to the inactivated suckling mouse brain vaccine utilized in anti-rabies campaigns in Brazil |
author |
Almeida, Marilene F. |
author_facet |
Almeida, Marilene F. Aguiar, Elizabeth A. C. Martorelli, Luzia A. F. Presotto, Douglas Brandão, Marcelo M. Pereira, Octávio A. C. |
author_role |
author |
author2 |
Aguiar, Elizabeth A. C. Martorelli, Luzia A. F. Presotto, Douglas Brandão, Marcelo M. Pereira, Octávio A. C. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Almeida, Marilene F. Aguiar, Elizabeth A. C. Martorelli, Luzia A. F. Presotto, Douglas Brandão, Marcelo M. Pereira, Octávio A. C. |
dc.subject.por.fl_str_mv |
Vacina anti-rábica^i1^simunolo Relação dose-resposta imunológica Rabies vaccine Dose-response relationship^i2^simmunolo |
topic |
Vacina anti-rábica^i1^simunolo Relação dose-resposta imunológica Rabies vaccine Dose-response relationship^i2^simmunolo |
description |
INTRODUCTION: An anti-rabies campaign is undertaken annually in Brazil with of the Fuenzalida & Palacios vaccine. The humoral immune response of dogs vaccinated during the campaigns was researched with the objective of evaluating whether the dogs presented a protective titer (0.5 UI/ml) 12 months after vaccination and how many of these achieved this titer 30 days after a buttressing vaccination. MATERIAL AND METHOD: Three hundred and forty-one specimens of serum of dogs domicilied, 259 in the S. Paulo and 82 in the Paulinia counties, were analyzed utilizing the Rapid Fluorescence Focus Inhibition Test. The immune response was evaluated taking into consideration the nutritional state of the animal and the number of previous vaccinations. RESULTS: The larger number of the dogs had not achieved the 0.5 UI/ml titer after 12 months, independently of the nutritional state and the response to the buttressing vaccination was more apparent in dogs with two or more previous vaccinations. DISCUSSION: The cut off of 0.5 Ul/ml as protective titer in dogs and the influence of the nutritional state and health conditions of the animals as responsible for humoral immune response are discussed. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/24317 10.1590/S0034-89101997000600009 |
url |
https://www.revistas.usp.br/rsp/article/view/24317 |
identifier_str_mv |
10.1590/S0034-89101997000600009 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/24317/26241 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista de Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista de Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 31 No. 5 (1997); 502-507 Revista de Saúde Pública; Vol. 31 Núm. 5 (1997); 502-507 Revista de Saúde Pública; v. 31 n. 5 (1997); 502-507 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1800221778363023360 |