Assessment and prediction of asthma and its severity in the pediatric community
Autor(a) principal: | |
---|---|
Data de Publicação: | 1990 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/23771 |
Resumo: | Seventy four asthmatic children aged 7 to 11 years were examined along with controls matched by age and sex. Clinical and laboratory investigations preceded a 28-day follow-up where data about morning and evening peak expiratory flow rate (PEF), symptoms and treatment were recorded. The coefficient of variation of PEF was found to be an objective measurement of asthma severity that has statistically significant correlation with both symptoms (r s= .36) and treatment (r s= .60). Moreover, it separates mild and severe asthmatics, as confirmed by statistically significant differences (p= .008 or less) in symptoms, treatment, skin allergy and airways response to exercise. Skin allergy and airways responsiveness to exercise were found to be predictors of both disease and severity. By means of logistic regression analysis it was possible to establish the probabilities for both asthma and severe asthma when children presenting and not presenting these characteristics are compared. One single positive skin test represent a probability of 88% for the development of asthma and a probability of 70% for severe disease. A PEF reduction of 10% after an exercise test implies a probability of 73% for disease and a probability of 64% for severe disease. Increases in these variables imply geometrically increased risks and their presence together have a multiplicative effect in the final risk. |
id |
USP-23_f18f51fdca86a376da198715e6baed85 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/23771 |
network_acronym_str |
USP-23 |
network_name_str |
Revista de Saúde Pública |
repository_id_str |
|
spelling |
Assessment and prediction of asthma and its severity in the pediatric community Avaliação e predição da asma e sua gravidade na comunidade pediátrica Asma^i2^sepidemioloValor de predição dos testesRiscoAsthma^i1^sepidemiolPredictive value of testsRisk Seventy four asthmatic children aged 7 to 11 years were examined along with controls matched by age and sex. Clinical and laboratory investigations preceded a 28-day follow-up where data about morning and evening peak expiratory flow rate (PEF), symptoms and treatment were recorded. The coefficient of variation of PEF was found to be an objective measurement of asthma severity that has statistically significant correlation with both symptoms (r s= .36) and treatment (r s= .60). Moreover, it separates mild and severe asthmatics, as confirmed by statistically significant differences (p= .008 or less) in symptoms, treatment, skin allergy and airways response to exercise. Skin allergy and airways responsiveness to exercise were found to be predictors of both disease and severity. By means of logistic regression analysis it was possible to establish the probabilities for both asthma and severe asthma when children presenting and not presenting these characteristics are compared. One single positive skin test represent a probability of 88% for the development of asthma and a probability of 70% for severe disease. A PEF reduction of 10% after an exercise test implies a probability of 73% for disease and a probability of 64% for severe disease. Increases in these variables imply geometrically increased risks and their presence together have a multiplicative effect in the final risk. Foram submetidas a exames, juntamente com grupos controle segundo idade e sexo,74 crianças asmáticas, com idade de 7 a 11 anos. Exames clínicos e laboratoriais precederam um acompanhamento de 28 dias, quando foram registrados dados sobre a taxa de pico do fluxo respiratório (PEF), sintomas e tratamento. Observou-se que o coeficiente de variação do PEF é uma medida objetiva do grau de gravidade da asma, que tem uma correlação estatística significativa, tanto com os sintomas (r s = .036), quanto com o tratamento (r s = .60). Além disso, separa os asmáticos graves e leves, como foi confirmado pelas diferenças estatisticamente significantes (p = 008 ou menos) nos sintomas, tratamentos, alergias da pele e resposta das vias aéreas ao exercício. Estas duas últimas foram consideradas elementos prognosticadores tanto da doença como do grau de gravidade. Pela regressão logística foi possível estabelecer a probabilidade para a asma grave quando as crianças, apresentando ou não essas características, foram comparadas. Um único teste de pele positivo representa uma probabilidade de 88% para o desenvolvimento de asma, e de 70% para doença grave. A redução do PEF de 10%, depois de um teste de exercício, leva a uma probabilidade de 73% de doença e de 64% para doença grave. Aumentos nessas variáveis implicam riscos aumentados geométricamente, cuja presença conjunta tem efeito multiplicativo no risco final. Universidade de São Paulo. Faculdade de Saúde Pública1990-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/2377110.1590/S0034-89101990000600001Revista de Saúde Pública; Vol. 24 No. 6 (1990); 437-444 Revista de Saúde Pública; Vol. 24 Núm. 6 (1990); 437-444 Revista de Saúde Pública; v. 24 n. 6 (1990); 437-444 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/rsp/article/view/23771/25807Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessPereira, Julio Cesar R.Carswell, FlemingHughes, Anthony O.2012-05-28T20:48:37Zoai:revistas.usp.br:article/23771Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-05-28T20:48:37Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Assessment and prediction of asthma and its severity in the pediatric community Avaliação e predição da asma e sua gravidade na comunidade pediátrica |
title |
Assessment and prediction of asthma and its severity in the pediatric community |
spellingShingle |
Assessment and prediction of asthma and its severity in the pediatric community Pereira, Julio Cesar R. Asma^i2^sepidemiolo Valor de predição dos testes Risco Asthma^i1^sepidemiol Predictive value of tests Risk |
title_short |
Assessment and prediction of asthma and its severity in the pediatric community |
title_full |
Assessment and prediction of asthma and its severity in the pediatric community |
title_fullStr |
Assessment and prediction of asthma and its severity in the pediatric community |
title_full_unstemmed |
Assessment and prediction of asthma and its severity in the pediatric community |
title_sort |
Assessment and prediction of asthma and its severity in the pediatric community |
author |
Pereira, Julio Cesar R. |
author_facet |
Pereira, Julio Cesar R. Carswell, Fleming Hughes, Anthony O. |
author_role |
author |
author2 |
Carswell, Fleming Hughes, Anthony O. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Pereira, Julio Cesar R. Carswell, Fleming Hughes, Anthony O. |
dc.subject.por.fl_str_mv |
Asma^i2^sepidemiolo Valor de predição dos testes Risco Asthma^i1^sepidemiol Predictive value of tests Risk |
topic |
Asma^i2^sepidemiolo Valor de predição dos testes Risco Asthma^i1^sepidemiol Predictive value of tests Risk |
description |
Seventy four asthmatic children aged 7 to 11 years were examined along with controls matched by age and sex. Clinical and laboratory investigations preceded a 28-day follow-up where data about morning and evening peak expiratory flow rate (PEF), symptoms and treatment were recorded. The coefficient of variation of PEF was found to be an objective measurement of asthma severity that has statistically significant correlation with both symptoms (r s= .36) and treatment (r s= .60). Moreover, it separates mild and severe asthmatics, as confirmed by statistically significant differences (p= .008 or less) in symptoms, treatment, skin allergy and airways response to exercise. Skin allergy and airways responsiveness to exercise were found to be predictors of both disease and severity. By means of logistic regression analysis it was possible to establish the probabilities for both asthma and severe asthma when children presenting and not presenting these characteristics are compared. One single positive skin test represent a probability of 88% for the development of asthma and a probability of 70% for severe disease. A PEF reduction of 10% after an exercise test implies a probability of 73% for disease and a probability of 64% for severe disease. Increases in these variables imply geometrically increased risks and their presence together have a multiplicative effect in the final risk. |
publishDate |
1990 |
dc.date.none.fl_str_mv |
1990-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/23771 10.1590/S0034-89101990000600001 |
url |
https://www.revistas.usp.br/rsp/article/view/23771 |
identifier_str_mv |
10.1590/S0034-89101990000600001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/23771/25807 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista de Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista de Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 24 No. 6 (1990); 437-444 Revista de Saúde Pública; Vol. 24 Núm. 6 (1990); 437-444 Revista de Saúde Pública; v. 24 n. 6 (1990); 437-444 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1800221775475245056 |