Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil

Detalhes bibliográficos
Autor(a) principal: Lopes, Carmen L R
Data de Publicação: 2009
Outros Autores: Teles, Sheila A, Espírito-Santo, Márcia P, Lampe, Elisabete, Rodrigues, Fabiana P, Motta-Castro, Ana Rita C, Marinho, Thaís A, Reis, Nádia R, Silva, Ágabo M C, Martins, Regina M B
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/32667
Resumo: OBJECTIVE: To estimate prevalence of hepatitis C virus (HCV) infection and identify risk factors associated and circulating HCV genotypes and subtypes. METHODS: Study conducted including 691 drug users attending 26 charitable, private and public drug treatment centers in Goiânia and Campo Grande, central-western Brazil, between 2005 and 2006. Sociodemographic characteristics and risk factors for HCV infection were collected during interviews. Blood samples were tested for HCV antibodies (anti-HCV). Positive samples were submitted to HCV RNA detection by PCR with primers complementary to 5' NC and NS5B regions of viral genome and genotyped by line probe assay (LiPA) and direct nucleotide sequencing followed by phylogenetic analysis. The prevalence and odds ratio were calculated with 95% confidence intervals. Risk factors were first estimated in the univariate analysis (p
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spelling Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil Prevalencia, factores de riesgo y genotipos de la hepatitis C entre usuarios de drogas Prevalência, fatores de risco e genótipos da hepatite C entre usuários de drogas Hepatite CAnticorpos Anti-Hepatite C^i1^suso diagnóstAnticorpos Anti-Hepatite C^i1^sgenétAbuso de Substâncias por Via IntravenosaUso Comum de Agulhas e SeringasFatores de RiscoEstudos SoroepidemiológicosHepatitis CAnticuerpos contra la Hepatitis C^i3^suso diagnóstHepacivirus^i3^sgenétAbuso de Sustancias por Vía IntravenosaCompartimiento de AgujasFactores de RiesgoEstudios SeroepidemiológicosHepatitis CHepatitis C Antibodies^i2^sdiagnosticHepacivirus^i2^sgenetSubstance AbuseIntravenousNeedle SharingRisk FactorsSeroepidemiologic Studies OBJECTIVE: To estimate prevalence of hepatitis C virus (HCV) infection and identify risk factors associated and circulating HCV genotypes and subtypes. METHODS: Study conducted including 691 drug users attending 26 charitable, private and public drug treatment centers in Goiânia and Campo Grande, central-western Brazil, between 2005 and 2006. Sociodemographic characteristics and risk factors for HCV infection were collected during interviews. Blood samples were tested for HCV antibodies (anti-HCV). Positive samples were submitted to HCV RNA detection by PCR with primers complementary to 5' NC and NS5B regions of viral genome and genotyped by line probe assay (LiPA) and direct nucleotide sequencing followed by phylogenetic analysis. The prevalence and odds ratio were calculated with 95% confidence intervals. Risk factors were first estimated in the univariate analysis (p OBJETIVO: Estimar la prevalencia y factores asociados a la infección por el virus de la hepatitis C en usuarios de drogas e identificar los genotipos y subtipos virales circulantes. MÉTODOS: Estudio realizado con 691 usuarios de drogas de 26 centros de tratamiento de uso de drogas filantrópicos, particulares y públicos de Goiania y Campo Grande (Centro-Oeste), entre 2005 y 2006. Datos sociodemográficos y factores de riesgo para infección por el HCV fueron obtenidos por medio de entrevistas. Muestras sanguíneas fueron evaluadas para la detección de anticuerpos para el HCV. Las muestras positivas fueron sometidas a la detección de RNA-HCV por la reacción en cadena de polimerasa con iniciadores complementarios a las regiones 5' NC y NS5B del genoma viral y genotipadas por el line probe assay (LiPA) y por secuenciación directa, seguido del análisis filogenético. Prevalencia y odds ratio fueron calculados con intervalo de 95% de confianza. Los factores de riesgo con p OBJETIVO: Estimar a prevalência e fatores associados à infecção pelo vírus da hepatite C em usuários de drogas e identificar os genótipos e subtipos virais circulantes. MÉTODOS: Estudo realizado com 691 usuários de drogas de 26 centros de tratamento de uso de drogas filantrópicos, particulares e públicos de Goiânia (GO) e Campo Grande (MS), entre 2005 e 2006. Dados sociodemográficos e fatores de risco para infecção pelo HCV foram obtidos por meio de entrevistas. Amostras sangüíneas foram testadas para a detecção de anticorpos para o HCV. As amostras positivas foram submetidas à detecção do RNA-HCV pela reação em cadeia da polimerase com iniciadores complementares às regiões 5' NC e NS5B do genoma viral e genotipadas pelo line probe assay (LiPA) e por seqüenciamento direto, seguido de análise filogenética. Prevalência e odds ratio foram calculados com intervalo de 95% de confiança. Os fatores de risco com pUniversidade de São Paulo. Faculdade de Saúde Pública2009-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/3266710.1590/S0034-89102009000800008Revista de Saúde Pública; Vol. 43 No. suppl.1 (2009); 43-50 Revista de Saúde Pública; Vol. 43 Núm. suppl.1 (2009); 43-50 Revista de Saúde Pública; v. 43 n. suppl.1 (2009); 43-50 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporenghttps://www.revistas.usp.br/rsp/article/view/32667/35068https://www.revistas.usp.br/rsp/article/view/32667/35069Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessLopes, Carmen L RTeles, Sheila AEspírito-Santo, Márcia PLampe, ElisabeteRodrigues, Fabiana PMotta-Castro, Ana Rita CMarinho, Thaís AReis, Nádia RSilva, Ágabo M CMartins, Regina M B2012-07-09T02:08:34Zoai:revistas.usp.br:article/32667Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-09T02:08:34Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil
Prevalencia, factores de riesgo y genotipos de la hepatitis C entre usuarios de drogas
Prevalência, fatores de risco e genótipos da hepatite C entre usuários de drogas
title Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil
spellingShingle Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil
Lopes, Carmen L R
Hepatite C
Anticorpos Anti-Hepatite C^i1^suso diagnóst
Anticorpos Anti-Hepatite C^i1^sgenét
Abuso de Substâncias por Via Intravenosa
Uso Comum de Agulhas e Seringas
Fatores de Risco
Estudos Soroepidemiológicos
Hepatitis C
Anticuerpos contra la Hepatitis C^i3^suso diagnóst
Hepacivirus^i3^sgenét
Abuso de Sustancias por Vía Intravenosa
Compartimiento de Agujas
Factores de Riesgo
Estudios Seroepidemiológicos
Hepatitis C
Hepatitis C Antibodies^i2^sdiagnostic
Hepacivirus^i2^sgenet
Substance Abuse
Intravenous
Needle Sharing
Risk Factors
Seroepidemiologic Studies
title_short Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil
title_full Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil
title_fullStr Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil
title_full_unstemmed Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil
title_sort Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil
author Lopes, Carmen L R
author_facet Lopes, Carmen L R
Teles, Sheila A
Espírito-Santo, Márcia P
Lampe, Elisabete
Rodrigues, Fabiana P
Motta-Castro, Ana Rita C
Marinho, Thaís A
Reis, Nádia R
Silva, Ágabo M C
Martins, Regina M B
author_role author
author2 Teles, Sheila A
Espírito-Santo, Márcia P
Lampe, Elisabete
Rodrigues, Fabiana P
Motta-Castro, Ana Rita C
Marinho, Thaís A
Reis, Nádia R
Silva, Ágabo M C
Martins, Regina M B
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes, Carmen L R
Teles, Sheila A
Espírito-Santo, Márcia P
Lampe, Elisabete
Rodrigues, Fabiana P
Motta-Castro, Ana Rita C
Marinho, Thaís A
Reis, Nádia R
Silva, Ágabo M C
Martins, Regina M B
dc.subject.por.fl_str_mv Hepatite C
Anticorpos Anti-Hepatite C^i1^suso diagnóst
Anticorpos Anti-Hepatite C^i1^sgenét
Abuso de Substâncias por Via Intravenosa
Uso Comum de Agulhas e Seringas
Fatores de Risco
Estudos Soroepidemiológicos
Hepatitis C
Anticuerpos contra la Hepatitis C^i3^suso diagnóst
Hepacivirus^i3^sgenét
Abuso de Sustancias por Vía Intravenosa
Compartimiento de Agujas
Factores de Riesgo
Estudios Seroepidemiológicos
Hepatitis C
Hepatitis C Antibodies^i2^sdiagnostic
Hepacivirus^i2^sgenet
Substance Abuse
Intravenous
Needle Sharing
Risk Factors
Seroepidemiologic Studies
topic Hepatite C
Anticorpos Anti-Hepatite C^i1^suso diagnóst
Anticorpos Anti-Hepatite C^i1^sgenét
Abuso de Substâncias por Via Intravenosa
Uso Comum de Agulhas e Seringas
Fatores de Risco
Estudos Soroepidemiológicos
Hepatitis C
Anticuerpos contra la Hepatitis C^i3^suso diagnóst
Hepacivirus^i3^sgenét
Abuso de Sustancias por Vía Intravenosa
Compartimiento de Agujas
Factores de Riesgo
Estudios Seroepidemiológicos
Hepatitis C
Hepatitis C Antibodies^i2^sdiagnostic
Hepacivirus^i2^sgenet
Substance Abuse
Intravenous
Needle Sharing
Risk Factors
Seroepidemiologic Studies
description OBJECTIVE: To estimate prevalence of hepatitis C virus (HCV) infection and identify risk factors associated and circulating HCV genotypes and subtypes. METHODS: Study conducted including 691 drug users attending 26 charitable, private and public drug treatment centers in Goiânia and Campo Grande, central-western Brazil, between 2005 and 2006. Sociodemographic characteristics and risk factors for HCV infection were collected during interviews. Blood samples were tested for HCV antibodies (anti-HCV). Positive samples were submitted to HCV RNA detection by PCR with primers complementary to 5' NC and NS5B regions of viral genome and genotyped by line probe assay (LiPA) and direct nucleotide sequencing followed by phylogenetic analysis. The prevalence and odds ratio were calculated with 95% confidence intervals. Risk factors were first estimated in the univariate analysis (p
publishDate 2009
dc.date.none.fl_str_mv 2009-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/32667
10.1590/S0034-89102009000800008
url https://www.revistas.usp.br/rsp/article/view/32667
identifier_str_mv 10.1590/S0034-89102009000800008
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/32667/35068
https://www.revistas.usp.br/rsp/article/view/32667/35069
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 43 No. suppl.1 (2009); 43-50
Revista de Saúde Pública; Vol. 43 Núm. suppl.1 (2009); 43-50
Revista de Saúde Pública; v. 43 n. suppl.1 (2009); 43-50
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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