Eventos adversos a antibióticos em pacientes internados em um hospital universitário
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/32346 |
Resumo: | OBJECTIVE: Antibiotics are the most common drugs causing adverse events and they lead to problems to patients and additional costs of the health system. The aim of the study was to evaluate the occurrence of adverse events to antibiotics in inpatients of a hospital. METHODS: An extensive drug monitoring was conducted in adult inpatients taking antibiotics in the city of Maringá, Southern Brazil, from September 2002 to February 2003. Variables related to medications used, especially those related to antibiotic use and adverse events, were studied. Based on criteria for adequate antibiotic use, the observed events were classified as adverse events, medication errors and near-misses. For the analysis of causality between drug administration and event occurrence Naranjo algorithm was used. RESULTS: A total of 87 patients were studied and 91 adverse events were identified: three (3.3%) adverse drug reactions; seven (7.7%) medication errors; and 81 (89.0%) medication near-misses. Adverse drug reactions were related to the use of quinolones and likely according to Naranjo algorithm. The seven medication errors were associated to four inadequately prescribed doses and three drug interactions. CONCLUSIONS: The study results indicate that an inadequate knowledge on antibiotics or lack of information about the patient at the time of prescription were the major factors involved in the occurrence of adverse events. |
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Eventos adversos a antibióticos em pacientes internados em um hospital universitário Adverse events to antibiotics in inpatients of a university hospital Agentes antibacterianos^i1^sefeitos adverPrescrição de medicamentosErros de medicaçãoPacientes internadosHospitais universitáriosFarmacovigilânciaAnti-bacterial agents^i2^sadverse effePrescriptionsdrugMedication errorsInpatientsHospitalsuniversityDrug surveillance OBJECTIVE: Antibiotics are the most common drugs causing adverse events and they lead to problems to patients and additional costs of the health system. The aim of the study was to evaluate the occurrence of adverse events to antibiotics in inpatients of a hospital. METHODS: An extensive drug monitoring was conducted in adult inpatients taking antibiotics in the city of Maringá, Southern Brazil, from September 2002 to February 2003. Variables related to medications used, especially those related to antibiotic use and adverse events, were studied. Based on criteria for adequate antibiotic use, the observed events were classified as adverse events, medication errors and near-misses. For the analysis of causality between drug administration and event occurrence Naranjo algorithm was used. RESULTS: A total of 87 patients were studied and 91 adverse events were identified: three (3.3%) adverse drug reactions; seven (7.7%) medication errors; and 81 (89.0%) medication near-misses. Adverse drug reactions were related to the use of quinolones and likely according to Naranjo algorithm. The seven medication errors were associated to four inadequately prescribed doses and three drug interactions. CONCLUSIONS: The study results indicate that an inadequate knowledge on antibiotics or lack of information about the patient at the time of prescription were the major factors involved in the occurrence of adverse events. OBJETIVO: Antibióticos são os medicamentos que mais causam eventos adversos, gerando problemas aos pacientes e custos adicionais ao sistema de saúde. Assim, objetivou-se analisar a ocorrência de eventos adversos a antibióticos em pacientes internados em um hospital. MÉTODOS: Realizou-se monitoramento intensivo do uso de antibióticos em pacientes adultos internados no município de Maringá, Paraná, de setembro de 2002 a fevereiro de 2003. Foram pesquisadas variáveis relativas aos medicamentos em uso, em particular aos antibióticos e aos eventos adversos. Com base em critérios para a avaliação do uso correto dos antibióticos, os eventos observados foram classificados como reações adversas, erros de medicação e "quase erros". Para relação de causalidade entre a administração do fármaco e o surgimento dos eventos utilizou-se o algoritmo de Naranjo. RESULTADOS: Foram acompanhados 87 pacientes e identificados 91 eventos adversos, sendo três deles (3,3%) reações adversas a medicamentos, sete (7,7%) erros de medicação, e 81 (89,0%) "quase erros". As reações a medicamentos ocorreram devido ao uso de quinolonas e foram consideradas "prováveis" utilizando-se o algoritmo de Naranjo. Os sete erros de medicação ocorreram devido a quatro prescrições incorretas de dose e três interações medicamentosas. CONCLUSÕES: Os resultados sugerem que a falta de conhecimento do medicamento ou a falta de informação sobre o paciente no momento da prescrição tenham sido os principais fatores envolvidos na ocorrência das reações a medicamentos. Universidade de São Paulo. Faculdade de Saúde Pública2007-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/3234610.1590/S0034-89102006005000049Revista de Saúde Pública; Vol. 41 No. 6 (2007); 1042-1048 Revista de Saúde Pública; Vol. 41 Núm. 6 (2007); 1042-1048 Revista de Saúde Pública; v. 41 n. 6 (2007); 1042-1048 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporenghttps://www.revistas.usp.br/rsp/article/view/32346/34529https://www.revistas.usp.br/rsp/article/view/32346/34530Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessLouro, EstelaRomano-Lieber, Nicolina SilvanaRibeiro, Eliane2012-07-09T00:47:24Zoai:revistas.usp.br:article/32346Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-09T00:47:24Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Eventos adversos a antibióticos em pacientes internados em um hospital universitário Adverse events to antibiotics in inpatients of a university hospital |
title |
Eventos adversos a antibióticos em pacientes internados em um hospital universitário |
spellingShingle |
Eventos adversos a antibióticos em pacientes internados em um hospital universitário Louro, Estela Agentes antibacterianos^i1^sefeitos adver Prescrição de medicamentos Erros de medicação Pacientes internados Hospitais universitários Farmacovigilância Anti-bacterial agents^i2^sadverse effe Prescriptions drug Medication errors Inpatients Hospitals university Drug surveillance |
title_short |
Eventos adversos a antibióticos em pacientes internados em um hospital universitário |
title_full |
Eventos adversos a antibióticos em pacientes internados em um hospital universitário |
title_fullStr |
Eventos adversos a antibióticos em pacientes internados em um hospital universitário |
title_full_unstemmed |
Eventos adversos a antibióticos em pacientes internados em um hospital universitário |
title_sort |
Eventos adversos a antibióticos em pacientes internados em um hospital universitário |
author |
Louro, Estela |
author_facet |
Louro, Estela Romano-Lieber, Nicolina Silvana Ribeiro, Eliane |
author_role |
author |
author2 |
Romano-Lieber, Nicolina Silvana Ribeiro, Eliane |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Louro, Estela Romano-Lieber, Nicolina Silvana Ribeiro, Eliane |
dc.subject.por.fl_str_mv |
Agentes antibacterianos^i1^sefeitos adver Prescrição de medicamentos Erros de medicação Pacientes internados Hospitais universitários Farmacovigilância Anti-bacterial agents^i2^sadverse effe Prescriptions drug Medication errors Inpatients Hospitals university Drug surveillance |
topic |
Agentes antibacterianos^i1^sefeitos adver Prescrição de medicamentos Erros de medicação Pacientes internados Hospitais universitários Farmacovigilância Anti-bacterial agents^i2^sadverse effe Prescriptions drug Medication errors Inpatients Hospitals university Drug surveillance |
description |
OBJECTIVE: Antibiotics are the most common drugs causing adverse events and they lead to problems to patients and additional costs of the health system. The aim of the study was to evaluate the occurrence of adverse events to antibiotics in inpatients of a hospital. METHODS: An extensive drug monitoring was conducted in adult inpatients taking antibiotics in the city of Maringá, Southern Brazil, from September 2002 to February 2003. Variables related to medications used, especially those related to antibiotic use and adverse events, were studied. Based on criteria for adequate antibiotic use, the observed events were classified as adverse events, medication errors and near-misses. For the analysis of causality between drug administration and event occurrence Naranjo algorithm was used. RESULTS: A total of 87 patients were studied and 91 adverse events were identified: three (3.3%) adverse drug reactions; seven (7.7%) medication errors; and 81 (89.0%) medication near-misses. Adverse drug reactions were related to the use of quinolones and likely according to Naranjo algorithm. The seven medication errors were associated to four inadequately prescribed doses and three drug interactions. CONCLUSIONS: The study results indicate that an inadequate knowledge on antibiotics or lack of information about the patient at the time of prescription were the major factors involved in the occurrence of adverse events. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/32346 10.1590/S0034-89102006005000049 |
url |
https://www.revistas.usp.br/rsp/article/view/32346 |
identifier_str_mv |
10.1590/S0034-89102006005000049 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/32346/34529 https://www.revistas.usp.br/rsp/article/view/32346/34530 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista de Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista de Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 41 No. 6 (2007); 1042-1048 Revista de Saúde Pública; Vol. 41 Núm. 6 (2007); 1042-1048 Revista de Saúde Pública; v. 41 n. 6 (2007); 1042-1048 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1800221786872217600 |