Prevalence of HIV-1 subtypes in patients of an urban center in Southern Brazil

• Autor(a) principal: Simon, Daniel
• Data de Publicação: 2010
• Outros Autores: Béria, Jorge Umberto, Tietzmann, Daniela Cardoso, Carli, Rafaela de, Stein, Airton Tetelbom, Lunge, Vagner Ricardo
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista de Saúde Pública
• Texto Completo: https://www.revistas.usp.br/rsp/article/view/32868
• topic: Infecções por HIV; epidemiologia; Soroprevalência de HIV; Fatores de Risco; Síndrome de Imunodeficiência Adquirida; Estudos Transversais; Infecciones por VIH; epidemiología; Seroprevalencia de VIH; Factores de Riesgo; Síndrome de Inmunodeficiencia Adquirida; Estudios Transversales; HIV Infections; epidemiology; HIV Seroprevalence; Risk Factors; Acquired Immunodeficiency Syndrome; Cross-Sectional Studies

OBJECTIVE: To estimate the prevalence of HIV-1 subtypes and analyze factors associated. METHODS: A cross-sectional study was performed with a convenience sample of 80 adult HIV-positive patients, users of an AIDS/STD specialized service, in the city of Canoas, Southern Brazil, between July 2008 and January 2009. Determination of HIV subtypes was performed with the amplification of viral genome fragment, using polymerase chain reaction, followed by sequencing of the amplified fragments. Sociodemographic, clinical and behavioral variables were collected in a structured questionnaire. Univariate statistical analysis was performed, using chi-square test and Student's t-test. RESULTS: A higher prevalence of subtype C was found (43.8%; 95% CI: 32.9;54.6), followed by CRF31_BC (35.0%; 95% CI: 24.6;45.5) and subtypes B (18.8%; 95% CI: 10.2;27.3) and F (2.4%; 95% CI: 0;5.9). Other HIV-1 subtypes were not observed. Patients infected with CRF31_BC were diagnosed more recently than patients infected with subtype B (p