Effect of curcumin on acute chronic kidney disease due to ischemia-reperfusion syndrome
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Escola de Enfermagem da USP (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0080-62342022000200405 |
Resumo: | ABSTRACT Objective: To evaluate the effect of curcumin on renal function, hemodynamics, and renal oxidative profile of rats with chronic kidney disease (CKD) subjected to renal ischemia-reperfusion injury (IRI). Methods: Wistar rats, 250–300 g, distributed in four groups: Sham (n = 5), CKD simulation; CKD (n = 5), 5/6 renal ablation for CKD induction; CKD + IRI (n = 5), CKD and renal pedicle clamping for 30 minutes; and CKD + IRI+curcumin (n = 5), CKD + IRI, curcumin administration 30 mg/kg/day, orally, for 10 days. Renal function (inulin clearance, urine flow, plasma creatinine), hemodynamics (blood pressure), and oxidative profile (peroxides, TBARS, and urine nitrate, non-protein soluble thiols in renal tissue) were evaluated. Results: The CKD + IRI + curcumin group showed increased inulin clearance and reduced plasma creatinine, decreased RVR and increased RBF, decreased oxidative metabolites in urine and increased thiols in renal tissue when compared with the CKD + IRI group. Conclusion: The treatment with curcumin preserved renal function and hemodynamics of animals with acute CKD, improving oxidative profile, with reduction of oxidants and preservation of antioxidant reserve. |
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Effect of curcumin on acute chronic kidney disease due to ischemia-reperfusion syndromeRenal Insufficiency, ChronicIschemiaReperfusionCurcuminABSTRACT Objective: To evaluate the effect of curcumin on renal function, hemodynamics, and renal oxidative profile of rats with chronic kidney disease (CKD) subjected to renal ischemia-reperfusion injury (IRI). Methods: Wistar rats, 250–300 g, distributed in four groups: Sham (n = 5), CKD simulation; CKD (n = 5), 5/6 renal ablation for CKD induction; CKD + IRI (n = 5), CKD and renal pedicle clamping for 30 minutes; and CKD + IRI+curcumin (n = 5), CKD + IRI, curcumin administration 30 mg/kg/day, orally, for 10 days. Renal function (inulin clearance, urine flow, plasma creatinine), hemodynamics (blood pressure), and oxidative profile (peroxides, TBARS, and urine nitrate, non-protein soluble thiols in renal tissue) were evaluated. Results: The CKD + IRI + curcumin group showed increased inulin clearance and reduced plasma creatinine, decreased RVR and increased RBF, decreased oxidative metabolites in urine and increased thiols in renal tissue when compared with the CKD + IRI group. Conclusion: The treatment with curcumin preserved renal function and hemodynamics of animals with acute CKD, improving oxidative profile, with reduction of oxidants and preservation of antioxidant reserve.Universidade de São Paulo, Escola de Enfermagem2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0080-62342022000200405Revista da Escola de Enfermagem da USP v.56 n.spe 2022reponame:Revista da Escola de Enfermagem da USP (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/1980-220x-reeusp-2021-0440eninfo:eu-repo/semantics/openAccessSilva,Eloiza de OliveiraConde,CarolinaMachado,Douglas IkedoVentura,SaraCouto,Sheila Marques FernandesVattimo,Maria de Fátima Fernandeseng2022-06-27T00:00:00Zoai:scielo:S0080-62342022000200405Revistahttp://www.scielo.br/reeuspPUBhttps://old.scielo.br/oai/scielo-oai.php||nursingscholar@usp.br1980-220X0080-6234opendoar:2022-06-27T00:00Revista da Escola de Enfermagem da USP (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Effect of curcumin on acute chronic kidney disease due to ischemia-reperfusion syndrome |
title |
Effect of curcumin on acute chronic kidney disease due to ischemia-reperfusion syndrome |
spellingShingle |
Effect of curcumin on acute chronic kidney disease due to ischemia-reperfusion syndrome Silva,Eloiza de Oliveira Renal Insufficiency, Chronic Ischemia Reperfusion Curcumin |
title_short |
Effect of curcumin on acute chronic kidney disease due to ischemia-reperfusion syndrome |
title_full |
Effect of curcumin on acute chronic kidney disease due to ischemia-reperfusion syndrome |
title_fullStr |
Effect of curcumin on acute chronic kidney disease due to ischemia-reperfusion syndrome |
title_full_unstemmed |
Effect of curcumin on acute chronic kidney disease due to ischemia-reperfusion syndrome |
title_sort |
Effect of curcumin on acute chronic kidney disease due to ischemia-reperfusion syndrome |
author |
Silva,Eloiza de Oliveira |
author_facet |
Silva,Eloiza de Oliveira Conde,Carolina Machado,Douglas Ikedo Ventura,Sara Couto,Sheila Marques Fernandes Vattimo,Maria de Fátima Fernandes |
author_role |
author |
author2 |
Conde,Carolina Machado,Douglas Ikedo Ventura,Sara Couto,Sheila Marques Fernandes Vattimo,Maria de Fátima Fernandes |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Eloiza de Oliveira Conde,Carolina Machado,Douglas Ikedo Ventura,Sara Couto,Sheila Marques Fernandes Vattimo,Maria de Fátima Fernandes |
dc.subject.por.fl_str_mv |
Renal Insufficiency, Chronic Ischemia Reperfusion Curcumin |
topic |
Renal Insufficiency, Chronic Ischemia Reperfusion Curcumin |
description |
ABSTRACT Objective: To evaluate the effect of curcumin on renal function, hemodynamics, and renal oxidative profile of rats with chronic kidney disease (CKD) subjected to renal ischemia-reperfusion injury (IRI). Methods: Wistar rats, 250–300 g, distributed in four groups: Sham (n = 5), CKD simulation; CKD (n = 5), 5/6 renal ablation for CKD induction; CKD + IRI (n = 5), CKD and renal pedicle clamping for 30 minutes; and CKD + IRI+curcumin (n = 5), CKD + IRI, curcumin administration 30 mg/kg/day, orally, for 10 days. Renal function (inulin clearance, urine flow, plasma creatinine), hemodynamics (blood pressure), and oxidative profile (peroxides, TBARS, and urine nitrate, non-protein soluble thiols in renal tissue) were evaluated. Results: The CKD + IRI + curcumin group showed increased inulin clearance and reduced plasma creatinine, decreased RVR and increased RBF, decreased oxidative metabolites in urine and increased thiols in renal tissue when compared with the CKD + IRI group. Conclusion: The treatment with curcumin preserved renal function and hemodynamics of animals with acute CKD, improving oxidative profile, with reduction of oxidants and preservation of antioxidant reserve. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0080-62342022000200405 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0080-62342022000200405 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1980-220x-reeusp-2021-0440en |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo, Escola de Enfermagem |
publisher.none.fl_str_mv |
Universidade de São Paulo, Escola de Enfermagem |
dc.source.none.fl_str_mv |
Revista da Escola de Enfermagem da USP v.56 n.spe 2022 reponame:Revista da Escola de Enfermagem da USP (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista da Escola de Enfermagem da USP (Online) |
collection |
Revista da Escola de Enfermagem da USP (Online) |
repository.name.fl_str_mv |
Revista da Escola de Enfermagem da USP (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||nursingscholar@usp.br |
_version_ |
1748936542295949312 |