Evaluation of triterpenes derivatives in the viability of Leishmania amazonensis and Trichomonas vaginalis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/181062 |
Resumo: | Trichomonas vaginalis and Leishmania spp. are protozoal species responsible for millions of cases of parasitic diseases worldwide. Considering the potential of natural products and the need for more effective and less toxic alternatives to treat trichomoniasis and leishmaniasis, this study aimed to evaluate the effect of two series of triterpenes derivatives with different modifications at C-3 and C-28 positions of the ursolic acid (UA) and betulinic acid (BA) against trophozoites of Trichomonas vaginalis and promastigotes forms of Leishmania (L.) amazonensis. The compounds modified just at C-3 were the most active. The 3β-acetyl betulinic acid (1b) reduced the trophozoites viability of T. vaginalis at 74%, followed by the 3-oxo ursolic acid and 3-oxo betulinic acid (3a and 3b) compounds (55% of reduction). The compound 3β-isobutyl ursolic acid (7a) inhibited the viability of L. amazonensis promastigotes by 55%. Therefore, analyzing the structure-activity relationship and the data of literature, it is possible to suppose that the inclusion of polar groups in the skeletons could improve the antiprotozoal activity. Overall, further studies are necessary to develop triterpenic derivatives with more powerful trichomonicidal and leishmanicidal properties. |
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oai:revistas.usp.br:article/181062 |
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USP-31 |
network_name_str |
Brazilian Journal of Pharmaceutical Sciences |
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Evaluation of triterpenes derivatives in the viability of Leishmania amazonensis and Trichomonas vaginalisBetulinic acidLeishmania amazonensisSemisynthesisTrichomonas vaginalis.Ursolic acidTrichomonas vaginalis and Leishmania spp. are protozoal species responsible for millions of cases of parasitic diseases worldwide. Considering the potential of natural products and the need for more effective and less toxic alternatives to treat trichomoniasis and leishmaniasis, this study aimed to evaluate the effect of two series of triterpenes derivatives with different modifications at C-3 and C-28 positions of the ursolic acid (UA) and betulinic acid (BA) against trophozoites of Trichomonas vaginalis and promastigotes forms of Leishmania (L.) amazonensis. The compounds modified just at C-3 were the most active. The 3β-acetyl betulinic acid (1b) reduced the trophozoites viability of T. vaginalis at 74%, followed by the 3-oxo ursolic acid and 3-oxo betulinic acid (3a and 3b) compounds (55% of reduction). The compound 3β-isobutyl ursolic acid (7a) inhibited the viability of L. amazonensis promastigotes by 55%. Therefore, analyzing the structure-activity relationship and the data of literature, it is possible to suppose that the inclusion of polar groups in the skeletons could improve the antiprotozoal activity. Overall, further studies are necessary to develop triterpenic derivatives with more powerful trichomonicidal and leishmanicidal properties.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2019-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18106210.1590/s2175-97902019000317481Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17481 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17481 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17481 2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/181062/168011Copyright (c) 2019 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCargnin, Simone Tasca Staudt, Andressa Finkler Menezes, Camila Azevedo, Ana Paula de Fialho, Saara Neri Tasca, Tiana Teles, Carolina Bioni Garcia Gnoatto, Simone Baggio 2021-01-19T16:47:29Zoai:revistas.usp.br:article/181062Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-01-19T16:47:29Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Evaluation of triterpenes derivatives in the viability of Leishmania amazonensis and Trichomonas vaginalis |
title |
Evaluation of triterpenes derivatives in the viability of Leishmania amazonensis and Trichomonas vaginalis |
spellingShingle |
Evaluation of triterpenes derivatives in the viability of Leishmania amazonensis and Trichomonas vaginalis Cargnin, Simone Tasca Betulinic acid Leishmania amazonensis Semisynthesis Trichomonas vaginalis. Ursolic acid |
title_short |
Evaluation of triterpenes derivatives in the viability of Leishmania amazonensis and Trichomonas vaginalis |
title_full |
Evaluation of triterpenes derivatives in the viability of Leishmania amazonensis and Trichomonas vaginalis |
title_fullStr |
Evaluation of triterpenes derivatives in the viability of Leishmania amazonensis and Trichomonas vaginalis |
title_full_unstemmed |
Evaluation of triterpenes derivatives in the viability of Leishmania amazonensis and Trichomonas vaginalis |
title_sort |
Evaluation of triterpenes derivatives in the viability of Leishmania amazonensis and Trichomonas vaginalis |
author |
Cargnin, Simone Tasca |
author_facet |
Cargnin, Simone Tasca Staudt, Andressa Finkler Menezes, Camila Azevedo, Ana Paula de Fialho, Saara Neri Tasca, Tiana Teles, Carolina Bioni Garcia Gnoatto, Simone Baggio |
author_role |
author |
author2 |
Staudt, Andressa Finkler Menezes, Camila Azevedo, Ana Paula de Fialho, Saara Neri Tasca, Tiana Teles, Carolina Bioni Garcia Gnoatto, Simone Baggio |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Cargnin, Simone Tasca Staudt, Andressa Finkler Menezes, Camila Azevedo, Ana Paula de Fialho, Saara Neri Tasca, Tiana Teles, Carolina Bioni Garcia Gnoatto, Simone Baggio |
dc.subject.por.fl_str_mv |
Betulinic acid Leishmania amazonensis Semisynthesis Trichomonas vaginalis. Ursolic acid |
topic |
Betulinic acid Leishmania amazonensis Semisynthesis Trichomonas vaginalis. Ursolic acid |
description |
Trichomonas vaginalis and Leishmania spp. are protozoal species responsible for millions of cases of parasitic diseases worldwide. Considering the potential of natural products and the need for more effective and less toxic alternatives to treat trichomoniasis and leishmaniasis, this study aimed to evaluate the effect of two series of triterpenes derivatives with different modifications at C-3 and C-28 positions of the ursolic acid (UA) and betulinic acid (BA) against trophozoites of Trichomonas vaginalis and promastigotes forms of Leishmania (L.) amazonensis. The compounds modified just at C-3 were the most active. The 3β-acetyl betulinic acid (1b) reduced the trophozoites viability of T. vaginalis at 74%, followed by the 3-oxo ursolic acid and 3-oxo betulinic acid (3a and 3b) compounds (55% of reduction). The compound 3β-isobutyl ursolic acid (7a) inhibited the viability of L. amazonensis promastigotes by 55%. Therefore, analyzing the structure-activity relationship and the data of literature, it is possible to suppose that the inclusion of polar groups in the skeletons could improve the antiprotozoal activity. Overall, further studies are necessary to develop triterpenic derivatives with more powerful trichomonicidal and leishmanicidal properties. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181062 10.1590/s2175-97902019000317481 |
url |
https://www.revistas.usp.br/bjps/article/view/181062 |
identifier_str_mv |
10.1590/s2175-97902019000317481 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181062/168011 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17481 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17481 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17481 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222915003678720 |