Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extract
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/159061 |
Resumo: | Generally, Plants have immense potential in the wounds management and treatment.In Chinese herbology, Hibiscus plant is a potent herb and have a good medicinal values but not scientifically approached. The present study aims to investigate the wound healing and antimicrobial activity of ethanolic extract of Hibiscus hirtus Linn.(HH). Wound healing activity was carried out by excision, incision and burn wound models. Antimicrobial activity was determined by cup plate method. Healing rate was assessed from the rate of wound contraction, epithelialization rate, tensile strength, hexosamine and hydroxyproline content. From the obtained results, it was indicated that the wound contraction and increased tensile strength of Hibiscus hirtus extract exhibits potent wound healing capacity. Hexosamine and hydroxyproline expression were also correlative with the pattern of healing observed. Histological observation indicates that the wounds treated with Hibiscus hirtus extract and povidone iodine have reduced scar formation and enhances fibroblast proliferation, angiogenesis, keratinization and epithelialization. The Hibiscus hirtus extract has excellent antimicrobial activity against the various organisms. Wound healing activity of our ethanolic extract of Hibiscus hirtus has shown the good effect which has proved by different physical, histological, biochemical parameters. Significant antimicrobial activity shown may be due to major active constituents present in plant. |
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Brazilian Journal of Pharmaceutical Sciences |
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Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extractHibiscus hirtus/wound healing activity/antimicrobial activityMedicinal plantsGenerally, Plants have immense potential in the wounds management and treatment.In Chinese herbology, Hibiscus plant is a potent herb and have a good medicinal values but not scientifically approached. The present study aims to investigate the wound healing and antimicrobial activity of ethanolic extract of Hibiscus hirtus Linn.(HH). Wound healing activity was carried out by excision, incision and burn wound models. Antimicrobial activity was determined by cup plate method. Healing rate was assessed from the rate of wound contraction, epithelialization rate, tensile strength, hexosamine and hydroxyproline content. From the obtained results, it was indicated that the wound contraction and increased tensile strength of Hibiscus hirtus extract exhibits potent wound healing capacity. Hexosamine and hydroxyproline expression were also correlative with the pattern of healing observed. Histological observation indicates that the wounds treated with Hibiscus hirtus extract and povidone iodine have reduced scar formation and enhances fibroblast proliferation, angiogenesis, keratinization and epithelialization. The Hibiscus hirtus extract has excellent antimicrobial activity against the various organisms. Wound healing activity of our ethanolic extract of Hibiscus hirtus has shown the good effect which has proved by different physical, histological, biochemical parameters. Significant antimicrobial activity shown may be due to major active constituents present in plant.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2018-12-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/15906110.1590/s2175-97902018000417075Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 4 (2018); e17075Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 4 (2018); e17075Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 4 (2018); e170752175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/159061/153988Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciencesinfo:eu-repo/semantics/openAccessRavishankar, KakaraparthyKiranmayi, Garlanka Venkata NagaPrasad, Yejella RajendraDevi, Lankadi2019-06-24T20:15:38Zoai:revistas.usp.br:article/159061Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2019-06-24T20:15:38Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extract |
title |
Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extract |
spellingShingle |
Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extract Ravishankar, Kakaraparthy Hibiscus hirtus/wound healing activity/antimicrobial activity Medicinal plants |
title_short |
Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extract |
title_full |
Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extract |
title_fullStr |
Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extract |
title_full_unstemmed |
Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extract |
title_sort |
Wound healing activity in rabbits and antimicrobial activity of Hibiscus hirtus ethanolic extract |
author |
Ravishankar, Kakaraparthy |
author_facet |
Ravishankar, Kakaraparthy Kiranmayi, Garlanka Venkata Naga Prasad, Yejella Rajendra Devi, Lankadi |
author_role |
author |
author2 |
Kiranmayi, Garlanka Venkata Naga Prasad, Yejella Rajendra Devi, Lankadi |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Ravishankar, Kakaraparthy Kiranmayi, Garlanka Venkata Naga Prasad, Yejella Rajendra Devi, Lankadi |
dc.subject.por.fl_str_mv |
Hibiscus hirtus/wound healing activity/antimicrobial activity Medicinal plants |
topic |
Hibiscus hirtus/wound healing activity/antimicrobial activity Medicinal plants |
description |
Generally, Plants have immense potential in the wounds management and treatment.In Chinese herbology, Hibiscus plant is a potent herb and have a good medicinal values but not scientifically approached. The present study aims to investigate the wound healing and antimicrobial activity of ethanolic extract of Hibiscus hirtus Linn.(HH). Wound healing activity was carried out by excision, incision and burn wound models. Antimicrobial activity was determined by cup plate method. Healing rate was assessed from the rate of wound contraction, epithelialization rate, tensile strength, hexosamine and hydroxyproline content. From the obtained results, it was indicated that the wound contraction and increased tensile strength of Hibiscus hirtus extract exhibits potent wound healing capacity. Hexosamine and hydroxyproline expression were also correlative with the pattern of healing observed. Histological observation indicates that the wounds treated with Hibiscus hirtus extract and povidone iodine have reduced scar formation and enhances fibroblast proliferation, angiogenesis, keratinization and epithelialization. The Hibiscus hirtus extract has excellent antimicrobial activity against the various organisms. Wound healing activity of our ethanolic extract of Hibiscus hirtus has shown the good effect which has proved by different physical, histological, biochemical parameters. Significant antimicrobial activity shown may be due to major active constituents present in plant. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/159061 10.1590/s2175-97902018000417075 |
url |
https://www.revistas.usp.br/bjps/article/view/159061 |
identifier_str_mv |
10.1590/s2175-97902018000417075 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/159061/153988 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 4 (2018); e17075 Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 4 (2018); e17075 Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 4 (2018); e17075 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222913856536576 |