Evolution of potential biomarkers of acute muscle injury after physical exercise
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/164801 |
Resumo: | Skeletal muscle injury is a frequent event and diagnosis using the classical blood markers sometimes produces unsatisfactory results. Therefore, objective of the study was to detect new biomarkers in plasma, saliva and urine in response to acute muscle damage induced by physical exercise. A cross-sectional study was conducted with 27 American football players. Before the physical exercises (T0), 60 minutes (T1) and 24 hours (T2) after physical exercise, was determined the clinical, biochemical and molecular parameters, including ADA, TBARS, leukocytes, lymphocytes and comet assay. The serum ADA was significantly higher in T1 and T2, in the urine there was a significant increase in T1, in the saliva there was no significant differences. There was an increase in serum TBARS in T2, saliva and urine in T1. The leukocytes increased in T1 and decreased in T2. Through the comet assay was observed significant DNA damage in T1 and T2. Serum and urinary ADA activity, serum, urinary and salivary TBARS are robust and promising biomarkers of acute muscle injury and that the comet assay allows a quick and effective evaluation of DNA lesions induced by physical exercise and could be used to monitor athletes avoiding injuries that are more serious. |
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Brazilian Journal of Pharmaceutical Sciences |
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Evolution of potential biomarkers of acute muscle injury after physical exerciseBiomarkers/serumBiomarkers/salivaBiomarkers/urineExerciseAthletesAthletic injuriesAdenosine deaminase/analysisDNASkeletal muscle injury is a frequent event and diagnosis using the classical blood markers sometimes produces unsatisfactory results. Therefore, objective of the study was to detect new biomarkers in plasma, saliva and urine in response to acute muscle damage induced by physical exercise. A cross-sectional study was conducted with 27 American football players. Before the physical exercises (T0), 60 minutes (T1) and 24 hours (T2) after physical exercise, was determined the clinical, biochemical and molecular parameters, including ADA, TBARS, leukocytes, lymphocytes and comet assay. The serum ADA was significantly higher in T1 and T2, in the urine there was a significant increase in T1, in the saliva there was no significant differences. There was an increase in serum TBARS in T2, saliva and urine in T1. The leukocytes increased in T1 and decreased in T2. Through the comet assay was observed significant DNA damage in T1 and T2. Serum and urinary ADA activity, serum, urinary and salivary TBARS are robust and promising biomarkers of acute muscle injury and that the comet assay allows a quick and effective evaluation of DNA lesions induced by physical exercise and could be used to monitor athletes avoiding injuries that are more serious.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2019-12-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/16480110.1590/s2175-97902019000117594Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17594Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17594Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e175942175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/164801/157983Copyright (c) 2019 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessChielle, Eduardo OttobelleGranella, Lucilene WildnerMaziero, Jorlana StackeVidigal, Tiago Mateus AndradeMallmann, Bárbara Lidiane KummerKaral, Jaison2021-01-11T18:39:36Zoai:revistas.usp.br:article/164801Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-01-11T18:39:36Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Evolution of potential biomarkers of acute muscle injury after physical exercise |
title |
Evolution of potential biomarkers of acute muscle injury after physical exercise |
spellingShingle |
Evolution of potential biomarkers of acute muscle injury after physical exercise Chielle, Eduardo Ottobelle Biomarkers/serum Biomarkers/saliva Biomarkers/urine Exercise Athletes Athletic injuries Adenosine deaminase/analysis DNA |
title_short |
Evolution of potential biomarkers of acute muscle injury after physical exercise |
title_full |
Evolution of potential biomarkers of acute muscle injury after physical exercise |
title_fullStr |
Evolution of potential biomarkers of acute muscle injury after physical exercise |
title_full_unstemmed |
Evolution of potential biomarkers of acute muscle injury after physical exercise |
title_sort |
Evolution of potential biomarkers of acute muscle injury after physical exercise |
author |
Chielle, Eduardo Ottobelle |
author_facet |
Chielle, Eduardo Ottobelle Granella, Lucilene Wildner Maziero, Jorlana Stacke Vidigal, Tiago Mateus Andrade Mallmann, Bárbara Lidiane Kummer Karal, Jaison |
author_role |
author |
author2 |
Granella, Lucilene Wildner Maziero, Jorlana Stacke Vidigal, Tiago Mateus Andrade Mallmann, Bárbara Lidiane Kummer Karal, Jaison |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Chielle, Eduardo Ottobelle Granella, Lucilene Wildner Maziero, Jorlana Stacke Vidigal, Tiago Mateus Andrade Mallmann, Bárbara Lidiane Kummer Karal, Jaison |
dc.subject.por.fl_str_mv |
Biomarkers/serum Biomarkers/saliva Biomarkers/urine Exercise Athletes Athletic injuries Adenosine deaminase/analysis DNA |
topic |
Biomarkers/serum Biomarkers/saliva Biomarkers/urine Exercise Athletes Athletic injuries Adenosine deaminase/analysis DNA |
description |
Skeletal muscle injury is a frequent event and diagnosis using the classical blood markers sometimes produces unsatisfactory results. Therefore, objective of the study was to detect new biomarkers in plasma, saliva and urine in response to acute muscle damage induced by physical exercise. A cross-sectional study was conducted with 27 American football players. Before the physical exercises (T0), 60 minutes (T1) and 24 hours (T2) after physical exercise, was determined the clinical, biochemical and molecular parameters, including ADA, TBARS, leukocytes, lymphocytes and comet assay. The serum ADA was significantly higher in T1 and T2, in the urine there was a significant increase in T1, in the saliva there was no significant differences. There was an increase in serum TBARS in T2, saliva and urine in T1. The leukocytes increased in T1 and decreased in T2. Through the comet assay was observed significant DNA damage in T1 and T2. Serum and urinary ADA activity, serum, urinary and salivary TBARS are robust and promising biomarkers of acute muscle injury and that the comet assay allows a quick and effective evaluation of DNA lesions induced by physical exercise and could be used to monitor athletes avoiding injuries that are more serious. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-05 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/164801 10.1590/s2175-97902019000117594 |
url |
https://www.revistas.usp.br/bjps/article/view/164801 |
identifier_str_mv |
10.1590/s2175-97902019000117594 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/164801/157983 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17594 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17594 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17594 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222914507702272 |