Anti-diabetic effect of betulinic acid on streptozotocinnicotinamide induced diabetic male mouse model
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/153782 |
Resumo: | Diabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin-nicotinamide (STZNA) diabetic mice. Seventy adult male NMRI mice were randomly divided into seven groups: control, sham, diabetic, diabetic treated with BA (10, 20 and 40 mg/kg) and diabetic treated with metformin (200 mg/kg). Diabetes was induced in mice by intraperitoneal injection of streptozotocin 50 mg/kg after a dose of nicotinamide 120 mg/kg. Two weeks after treatment with BA, blood samples were collected for measuring glucose, α-amylase and insulin levels, and the pancreas was isolated for histopathology evaluation. Diabetes reduced the number and diameter of pancreatic islets, and increased α-amylase and insulin resistance. BA treatment reduced blood glucose, α-amylase and improved insulin sensitivity as well as pancreas histopathology. In addition, BA showed stronger effects on the pancreatic histology and insulin resistance compared to the metformin group. |
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Brazilian Journal of Pharmaceutical Sciences |
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Anti-diabetic effect of betulinic acid on streptozotocinnicotinamide induced diabetic male mouse modelBetulinic acid. DiabetesMouseStreptozotocin-nicotinamideDiabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin-nicotinamide (STZNA) diabetic mice. Seventy adult male NMRI mice were randomly divided into seven groups: control, sham, diabetic, diabetic treated with BA (10, 20 and 40 mg/kg) and diabetic treated with metformin (200 mg/kg). Diabetes was induced in mice by intraperitoneal injection of streptozotocin 50 mg/kg after a dose of nicotinamide 120 mg/kg. Two weeks after treatment with BA, blood samples were collected for measuring glucose, α-amylase and insulin levels, and the pancreas was isolated for histopathology evaluation. Diabetes reduced the number and diameter of pancreatic islets, and increased α-amylase and insulin resistance. BA treatment reduced blood glucose, α-amylase and improved insulin sensitivity as well as pancreas histopathology. In addition, BA showed stronger effects on the pancreatic histology and insulin resistance compared to the metformin group.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2018-07-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/15378210.1590/s2175-97902018000217171Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 2 (2018); e17171Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 2 (2018); e17171Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 2 (2018); e171712175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/153782/150172Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessBirgani, Golshan ArzaniAhangarpour, AkramKhorsandi, LayasadatMoghaddam, Hadi Fathi2019-03-17T13:37:05Zoai:revistas.usp.br:article/153782Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2019-03-17T13:37:05Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Anti-diabetic effect of betulinic acid on streptozotocinnicotinamide induced diabetic male mouse model |
title |
Anti-diabetic effect of betulinic acid on streptozotocinnicotinamide induced diabetic male mouse model |
spellingShingle |
Anti-diabetic effect of betulinic acid on streptozotocinnicotinamide induced diabetic male mouse model Birgani, Golshan Arzani Betulinic acid. Diabetes Mouse Streptozotocin-nicotinamide |
title_short |
Anti-diabetic effect of betulinic acid on streptozotocinnicotinamide induced diabetic male mouse model |
title_full |
Anti-diabetic effect of betulinic acid on streptozotocinnicotinamide induced diabetic male mouse model |
title_fullStr |
Anti-diabetic effect of betulinic acid on streptozotocinnicotinamide induced diabetic male mouse model |
title_full_unstemmed |
Anti-diabetic effect of betulinic acid on streptozotocinnicotinamide induced diabetic male mouse model |
title_sort |
Anti-diabetic effect of betulinic acid on streptozotocinnicotinamide induced diabetic male mouse model |
author |
Birgani, Golshan Arzani |
author_facet |
Birgani, Golshan Arzani Ahangarpour, Akram Khorsandi, Layasadat Moghaddam, Hadi Fathi |
author_role |
author |
author2 |
Ahangarpour, Akram Khorsandi, Layasadat Moghaddam, Hadi Fathi |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Birgani, Golshan Arzani Ahangarpour, Akram Khorsandi, Layasadat Moghaddam, Hadi Fathi |
dc.subject.por.fl_str_mv |
Betulinic acid. Diabetes Mouse Streptozotocin-nicotinamide |
topic |
Betulinic acid. Diabetes Mouse Streptozotocin-nicotinamide |
description |
Diabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin-nicotinamide (STZNA) diabetic mice. Seventy adult male NMRI mice were randomly divided into seven groups: control, sham, diabetic, diabetic treated with BA (10, 20 and 40 mg/kg) and diabetic treated with metformin (200 mg/kg). Diabetes was induced in mice by intraperitoneal injection of streptozotocin 50 mg/kg after a dose of nicotinamide 120 mg/kg. Two weeks after treatment with BA, blood samples were collected for measuring glucose, α-amylase and insulin levels, and the pancreas was isolated for histopathology evaluation. Diabetes reduced the number and diameter of pancreatic islets, and increased α-amylase and insulin resistance. BA treatment reduced blood glucose, α-amylase and improved insulin sensitivity as well as pancreas histopathology. In addition, BA showed stronger effects on the pancreatic histology and insulin resistance compared to the metformin group. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/153782 10.1590/s2175-97902018000217171 |
url |
https://www.revistas.usp.br/bjps/article/view/153782 |
identifier_str_mv |
10.1590/s2175-97902018000217171 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/153782/150172 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 2 (2018); e17171 Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 2 (2018); e17171 Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 2 (2018); e17171 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222913705541632 |