Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/211883 |
Resumo: | Clay minerals are still widely used in pharmaceutical products for human health and cosmetic purposes. Pre-formulation studies were conducted to identify solid-state properties of pink clay, a sample from Diamantina, Brazil. Among the solid properties to be analyzed, we have selected type identification, iron phases, crystallinity, powder flow characteristics, thermal behavior, and non-isothermal phase transition kinetics. The pink clay is composed of (1:1) clay type and kaolinite as the main component. The Mössbauer spectrum of pink clay shows Fe3+(α-Fe2O3) hematite, Fe2+, and Fe3+ with large Δ/2ξq of about 2.80 and 2.69 mm.s-1 respectively, related to iron silicates, most likely pyroxene, and a superparamagnetic Fe3+. Pink clay exhibits poor flow properties. The thermal behavior indicates a phase-transition between 400 - 600 ºC associated with the dehydroxylation of the pink clay system requiring ~300 kJ mol-1, being constant until the process reaches a conversion of ~50% when the energy is enhanced to ~530 kJ mol-1, concluding the whole dehydroxylation process (α=80%). Solid-state properties and characteristics found for the pink clay must be considered for the proper design of formulations. This type of clay shows unique pharmaceutical properties that can be favorably exploited by the cosmetic industry. |
id |
USP-31_3b3d2a2b54e135b16a1d661e6ad72b65 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/211883 |
network_acronym_str |
USP-31 |
network_name_str |
Brazilian Journal of Pharmaceutical Sciences |
repository_id_str |
|
spelling |
Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation studyPink clay mineral; Thermal behavior; Iron phases; Powder technology; Solid-state stability; Kinetic studyClay minerals are still widely used in pharmaceutical products for human health and cosmetic purposes. Pre-formulation studies were conducted to identify solid-state properties of pink clay, a sample from Diamantina, Brazil. Among the solid properties to be analyzed, we have selected type identification, iron phases, crystallinity, powder flow characteristics, thermal behavior, and non-isothermal phase transition kinetics. The pink clay is composed of (1:1) clay type and kaolinite as the main component. The Mössbauer spectrum of pink clay shows Fe3+(α-Fe2O3) hematite, Fe2+, and Fe3+ with large Δ/2ξq of about 2.80 and 2.69 mm.s-1 respectively, related to iron silicates, most likely pyroxene, and a superparamagnetic Fe3+. Pink clay exhibits poor flow properties. The thermal behavior indicates a phase-transition between 400 - 600 ºC associated with the dehydroxylation of the pink clay system requiring ~300 kJ mol-1, being constant until the process reaches a conversion of ~50% when the energy is enhanced to ~530 kJ mol-1, concluding the whole dehydroxylation process (α=80%). Solid-state properties and characteristics found for the pink clay must be considered for the proper design of formulations. This type of clay shows unique pharmaceutical properties that can be favorably exploited by the cosmetic industry.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-05-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/21188310.1590/s2175-97902023e21460Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21460Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21460Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e214602175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/211883/194714https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessMarques, Maria Betânia de FreitasAlmeida, Osmar PatrícioAraújo, Bárbara Caroline RodriguesArdisson, José Domingosde Cássia de Oliveira Sebastião, Ritada Silva, Flávia Lidiane OliveiraMussel, Wagner da NovaYoshida, Maria IreneCarneiro, Guilherme2023-06-02T21:13:02Zoai:revistas.usp.br:article/211883Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-06-02T21:13:02Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study |
title |
Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study |
spellingShingle |
Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study Marques, Maria Betânia de Freitas Pink clay mineral; Thermal behavior; Iron phases; Powder technology; Solid-state stability; Kinetic study |
title_short |
Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study |
title_full |
Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study |
title_fullStr |
Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study |
title_full_unstemmed |
Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study |
title_sort |
Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study |
author |
Marques, Maria Betânia de Freitas |
author_facet |
Marques, Maria Betânia de Freitas Almeida, Osmar Patrício Araújo, Bárbara Caroline Rodrigues Ardisson, José Domingos de Cássia de Oliveira Sebastião, Rita da Silva, Flávia Lidiane Oliveira Mussel, Wagner da Nova Yoshida, Maria Irene Carneiro, Guilherme |
author_role |
author |
author2 |
Almeida, Osmar Patrício Araújo, Bárbara Caroline Rodrigues Ardisson, José Domingos de Cássia de Oliveira Sebastião, Rita da Silva, Flávia Lidiane Oliveira Mussel, Wagner da Nova Yoshida, Maria Irene Carneiro, Guilherme |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Marques, Maria Betânia de Freitas Almeida, Osmar Patrício Araújo, Bárbara Caroline Rodrigues Ardisson, José Domingos de Cássia de Oliveira Sebastião, Rita da Silva, Flávia Lidiane Oliveira Mussel, Wagner da Nova Yoshida, Maria Irene Carneiro, Guilherme |
dc.subject.por.fl_str_mv |
Pink clay mineral; Thermal behavior; Iron phases; Powder technology; Solid-state stability; Kinetic study |
topic |
Pink clay mineral; Thermal behavior; Iron phases; Powder technology; Solid-state stability; Kinetic study |
description |
Clay minerals are still widely used in pharmaceutical products for human health and cosmetic purposes. Pre-formulation studies were conducted to identify solid-state properties of pink clay, a sample from Diamantina, Brazil. Among the solid properties to be analyzed, we have selected type identification, iron phases, crystallinity, powder flow characteristics, thermal behavior, and non-isothermal phase transition kinetics. The pink clay is composed of (1:1) clay type and kaolinite as the main component. The Mössbauer spectrum of pink clay shows Fe3+(α-Fe2O3) hematite, Fe2+, and Fe3+ with large Δ/2ξq of about 2.80 and 2.69 mm.s-1 respectively, related to iron silicates, most likely pyroxene, and a superparamagnetic Fe3+. Pink clay exhibits poor flow properties. The thermal behavior indicates a phase-transition between 400 - 600 ºC associated with the dehydroxylation of the pink clay system requiring ~300 kJ mol-1, being constant until the process reaches a conversion of ~50% when the energy is enhanced to ~530 kJ mol-1, concluding the whole dehydroxylation process (α=80%). Solid-state properties and characteristics found for the pink clay must be considered for the proper design of formulations. This type of clay shows unique pharmaceutical properties that can be favorably exploited by the cosmetic industry. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-05-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/211883 10.1590/s2175-97902023e21460 |
url |
https://www.revistas.usp.br/bjps/article/view/211883 |
identifier_str_mv |
10.1590/s2175-97902023e21460 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/211883/194714 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21460 Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21460 Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21460 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222918056083456 |