Mechanical, optical, and physicochemical properties of HPMC-based doxazosin mesylate orodispersible films
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/210961 |
Resumo: | In this study, orodispersible films formed from hydroxypropyl methylcellulose (HPMC) E6 (2, 2.5, and 3%) and plasticizers ((glycerin (Gly), propylene glycol (PP), or polyethylene glycol (PEG)), containing doxazosin mesylate, were prepared by the solvent casting method and characterized. Design of experiments (DoE) was used as a statistical tool to facilitate the interpretation of the experimental data and allow the identification of optimal levels of factors for maximum formulation performance. Differential scanning calorimetry (DSC) curves and X-ray powder diffraction (XRPD) diffractograms showed doxazosin mesylate amorphization, probably due to complexation with the polymer (HPMC E6), and the glass transition temperature of the polymer was reduced by adding a plasticizer. Fourier transformed infrared (FTIR) spectroscopy results showed that the chemical structure of doxazosin mesylate was preserved when introduced into the polymer matrix, and the plasticizers, glycerin and PEG, affected the polymer matrix with high intensity. The addition of plasticizers increased the elongation at break and adhesiveness (Gly > PEG > PP), confirming the greater plasticizer effect of Gly observed in DSC and FTIR studies. Greater transparency was observed for the orodispersible films prepared using PP. The addition of citric acid as a pH modifier was fundamental for the release of doxazosin mesylate, and the desirability formulation had a release profile similar to that of the reference product. |
id |
USP-31_45d9e780419b10b581b5d077379f865f |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/210961 |
network_acronym_str |
USP-31 |
network_name_str |
Brazilian Journal of Pharmaceutical Sciences |
repository_id_str |
|
spelling |
Mechanical, optical, and physicochemical properties of HPMC-based doxazosin mesylate orodispersible filmsOrodispersible films; Design of experiments; Doxazosin mesylate; FTIR; Mechanical properties; Desirability functionIn this study, orodispersible films formed from hydroxypropyl methylcellulose (HPMC) E6 (2, 2.5, and 3%) and plasticizers ((glycerin (Gly), propylene glycol (PP), or polyethylene glycol (PEG)), containing doxazosin mesylate, were prepared by the solvent casting method and characterized. Design of experiments (DoE) was used as a statistical tool to facilitate the interpretation of the experimental data and allow the identification of optimal levels of factors for maximum formulation performance. Differential scanning calorimetry (DSC) curves and X-ray powder diffraction (XRPD) diffractograms showed doxazosin mesylate amorphization, probably due to complexation with the polymer (HPMC E6), and the glass transition temperature of the polymer was reduced by adding a plasticizer. Fourier transformed infrared (FTIR) spectroscopy results showed that the chemical structure of doxazosin mesylate was preserved when introduced into the polymer matrix, and the plasticizers, glycerin and PEG, affected the polymer matrix with high intensity. The addition of plasticizers increased the elongation at break and adhesiveness (Gly > PEG > PP), confirming the greater plasticizer effect of Gly observed in DSC and FTIR studies. Greater transparency was observed for the orodispersible films prepared using PP. The addition of citric acid as a pH modifier was fundamental for the release of doxazosin mesylate, and the desirability formulation had a release profile similar to that of the reference product.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-04-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/21096110.1590/s2175-97902023e21114Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21114Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21114Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e211142175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/210961/194407https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessPamela Coradi da SilvaLarissa Aroca ColucciLarissa Lea da SilvaCelso MolinaMarcelo Dutra DuqueLeticia Norma Carpentieri Rodrigues2023-05-24T17:29:08Zoai:revistas.usp.br:article/210961Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-05-24T17:29:08Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Mechanical, optical, and physicochemical properties of HPMC-based doxazosin mesylate orodispersible films |
title |
Mechanical, optical, and physicochemical properties of HPMC-based doxazosin mesylate orodispersible films |
spellingShingle |
Mechanical, optical, and physicochemical properties of HPMC-based doxazosin mesylate orodispersible films Pamela Coradi da Silva Orodispersible films; Design of experiments; Doxazosin mesylate; FTIR; Mechanical properties; Desirability function |
title_short |
Mechanical, optical, and physicochemical properties of HPMC-based doxazosin mesylate orodispersible films |
title_full |
Mechanical, optical, and physicochemical properties of HPMC-based doxazosin mesylate orodispersible films |
title_fullStr |
Mechanical, optical, and physicochemical properties of HPMC-based doxazosin mesylate orodispersible films |
title_full_unstemmed |
Mechanical, optical, and physicochemical properties of HPMC-based doxazosin mesylate orodispersible films |
title_sort |
Mechanical, optical, and physicochemical properties of HPMC-based doxazosin mesylate orodispersible films |
author |
Pamela Coradi da Silva |
author_facet |
Pamela Coradi da Silva Larissa Aroca Colucci Larissa Lea da Silva Celso Molina Marcelo Dutra Duque Leticia Norma Carpentieri Rodrigues |
author_role |
author |
author2 |
Larissa Aroca Colucci Larissa Lea da Silva Celso Molina Marcelo Dutra Duque Leticia Norma Carpentieri Rodrigues |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pamela Coradi da Silva Larissa Aroca Colucci Larissa Lea da Silva Celso Molina Marcelo Dutra Duque Leticia Norma Carpentieri Rodrigues |
dc.subject.por.fl_str_mv |
Orodispersible films; Design of experiments; Doxazosin mesylate; FTIR; Mechanical properties; Desirability function |
topic |
Orodispersible films; Design of experiments; Doxazosin mesylate; FTIR; Mechanical properties; Desirability function |
description |
In this study, orodispersible films formed from hydroxypropyl methylcellulose (HPMC) E6 (2, 2.5, and 3%) and plasticizers ((glycerin (Gly), propylene glycol (PP), or polyethylene glycol (PEG)), containing doxazosin mesylate, were prepared by the solvent casting method and characterized. Design of experiments (DoE) was used as a statistical tool to facilitate the interpretation of the experimental data and allow the identification of optimal levels of factors for maximum formulation performance. Differential scanning calorimetry (DSC) curves and X-ray powder diffraction (XRPD) diffractograms showed doxazosin mesylate amorphization, probably due to complexation with the polymer (HPMC E6), and the glass transition temperature of the polymer was reduced by adding a plasticizer. Fourier transformed infrared (FTIR) spectroscopy results showed that the chemical structure of doxazosin mesylate was preserved when introduced into the polymer matrix, and the plasticizers, glycerin and PEG, affected the polymer matrix with high intensity. The addition of plasticizers increased the elongation at break and adhesiveness (Gly > PEG > PP), confirming the greater plasticizer effect of Gly observed in DSC and FTIR studies. Greater transparency was observed for the orodispersible films prepared using PP. The addition of citric acid as a pH modifier was fundamental for the release of doxazosin mesylate, and the desirability formulation had a release profile similar to that of the reference product. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/210961 10.1590/s2175-97902023e21114 |
url |
https://www.revistas.usp.br/bjps/article/view/210961 |
identifier_str_mv |
10.1590/s2175-97902023e21114 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/210961/194407 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21114 Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21114 Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21114 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222917660770304 |