Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/207839 |
Resumo: | Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters. |
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Brazilian Journal of Pharmaceutical Sciences |
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Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular riskTriglyceridesLipoproteinsApolipoprotein A-IDyslipidemiaHypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-02-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20783910.1590/s2175-97902022e20488Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/207839/197700Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMeneses, Richard Rarison CavalcanteDamasceno, Nagila Raquel TeixeiraSampaio, Tiago LimaCartolano, Flavia de ContiLima Verde, Sara Maria MoreiraLira, Letícia GomesDantas, Mariana Britoda Silva, Mateus EdsonViana, Glautemberg Almeida de Sousa, Ederson Laurindo HolandaMeneses, Gdayllon CavalcanteFerreira, Jamile MagalhãesQueiroz, Maria Goretti Rodrigues de2023-08-30T20:33:52Zoai:revistas.usp.br:article/207839Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-08-30T20:33:52Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
title |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
spellingShingle |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk Meneses, Richard Rarison Cavalcante Triglycerides Lipoproteins Apolipoprotein A-I Dyslipidemia |
title_short |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
title_full |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
title_fullStr |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
title_full_unstemmed |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
title_sort |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
author |
Meneses, Richard Rarison Cavalcante |
author_facet |
Meneses, Richard Rarison Cavalcante Damasceno, Nagila Raquel Teixeira Sampaio, Tiago Lima Cartolano, Flavia de Conti Lima Verde, Sara Maria Moreira Lira, Letícia Gomes Dantas, Mariana Brito da Silva, Mateus Edson Viana, Glautemberg Almeida de Sousa, Ederson Laurindo Holanda Meneses, Gdayllon Cavalcante Ferreira, Jamile Magalhães Queiroz, Maria Goretti Rodrigues de |
author_role |
author |
author2 |
Damasceno, Nagila Raquel Teixeira Sampaio, Tiago Lima Cartolano, Flavia de Conti Lima Verde, Sara Maria Moreira Lira, Letícia Gomes Dantas, Mariana Brito da Silva, Mateus Edson Viana, Glautemberg Almeida de Sousa, Ederson Laurindo Holanda Meneses, Gdayllon Cavalcante Ferreira, Jamile Magalhães Queiroz, Maria Goretti Rodrigues de |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Meneses, Richard Rarison Cavalcante Damasceno, Nagila Raquel Teixeira Sampaio, Tiago Lima Cartolano, Flavia de Conti Lima Verde, Sara Maria Moreira Lira, Letícia Gomes Dantas, Mariana Brito da Silva, Mateus Edson Viana, Glautemberg Almeida de Sousa, Ederson Laurindo Holanda Meneses, Gdayllon Cavalcante Ferreira, Jamile Magalhães Queiroz, Maria Goretti Rodrigues de |
dc.subject.por.fl_str_mv |
Triglycerides Lipoproteins Apolipoprotein A-I Dyslipidemia |
topic |
Triglycerides Lipoproteins Apolipoprotein A-I Dyslipidemia |
description |
Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-02-07 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/207839 10.1590/s2175-97902022e20488 |
url |
https://www.revistas.usp.br/bjps/article/view/207839 |
identifier_str_mv |
10.1590/s2175-97902022e20488 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/207839/197700 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222917523406848 |