Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk

Detalhes bibliográficos
Autor(a) principal: Meneses, Richard Rarison Cavalcante
Data de Publicação: 2023
Outros Autores: Damasceno, Nagila Raquel Teixeira, Sampaio, Tiago Lima, Cartolano, Flavia de Conti, Lima Verde, Sara Maria Moreira, Lira, Letícia Gomes, Dantas, Mariana Brito, da Silva, Mateus Edson, Viana, Glautemberg Almeida, de Sousa, Ederson Laurindo Holanda, Meneses, Gdayllon Cavalcante, Ferreira, Jamile Magalhães, Queiroz, Maria Goretti Rodrigues de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/207839
Resumo: Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters.
id USP-31_589fb909c652788e5f7fc52d160f7ecb
oai_identifier_str oai:revistas.usp.br:article/207839
network_acronym_str USP-31
network_name_str Brazilian Journal of Pharmaceutical Sciences
repository_id_str
spelling Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular riskTriglyceridesLipoproteinsApolipoprotein A-IDyslipidemiaHypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-02-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20783910.1590/s2175-97902022e20488Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/207839/197700Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMeneses, Richard Rarison CavalcanteDamasceno, Nagila Raquel TeixeiraSampaio, Tiago LimaCartolano, Flavia de ContiLima Verde, Sara Maria MoreiraLira, Letícia GomesDantas, Mariana Britoda Silva, Mateus EdsonViana, Glautemberg Almeida de Sousa, Ederson Laurindo HolandaMeneses, Gdayllon CavalcanteFerreira, Jamile MagalhãesQueiroz, Maria Goretti Rodrigues de2023-08-30T20:33:52Zoai:revistas.usp.br:article/207839Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-08-30T20:33:52Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk
title Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk
spellingShingle Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk
Meneses, Richard Rarison Cavalcante
Triglycerides
Lipoproteins
Apolipoprotein A-I
Dyslipidemia
title_short Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk
title_full Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk
title_fullStr Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk
title_full_unstemmed Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk
title_sort Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk
author Meneses, Richard Rarison Cavalcante
author_facet Meneses, Richard Rarison Cavalcante
Damasceno, Nagila Raquel Teixeira
Sampaio, Tiago Lima
Cartolano, Flavia de Conti
Lima Verde, Sara Maria Moreira
Lira, Letícia Gomes
Dantas, Mariana Brito
da Silva, Mateus Edson
Viana, Glautemberg Almeida
de Sousa, Ederson Laurindo Holanda
Meneses, Gdayllon Cavalcante
Ferreira, Jamile Magalhães
Queiroz, Maria Goretti Rodrigues de
author_role author
author2 Damasceno, Nagila Raquel Teixeira
Sampaio, Tiago Lima
Cartolano, Flavia de Conti
Lima Verde, Sara Maria Moreira
Lira, Letícia Gomes
Dantas, Mariana Brito
da Silva, Mateus Edson
Viana, Glautemberg Almeida
de Sousa, Ederson Laurindo Holanda
Meneses, Gdayllon Cavalcante
Ferreira, Jamile Magalhães
Queiroz, Maria Goretti Rodrigues de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Meneses, Richard Rarison Cavalcante
Damasceno, Nagila Raquel Teixeira
Sampaio, Tiago Lima
Cartolano, Flavia de Conti
Lima Verde, Sara Maria Moreira
Lira, Letícia Gomes
Dantas, Mariana Brito
da Silva, Mateus Edson
Viana, Glautemberg Almeida
de Sousa, Ederson Laurindo Holanda
Meneses, Gdayllon Cavalcante
Ferreira, Jamile Magalhães
Queiroz, Maria Goretti Rodrigues de
dc.subject.por.fl_str_mv Triglycerides
Lipoproteins
Apolipoprotein A-I
Dyslipidemia
topic Triglycerides
Lipoproteins
Apolipoprotein A-I
Dyslipidemia
description Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters.
publishDate 2023
dc.date.none.fl_str_mv 2023-02-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/207839
10.1590/s2175-97902022e20488
url https://www.revistas.usp.br/bjps/article/view/207839
identifier_str_mv 10.1590/s2175-97902022e20488
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/207839/197700
dc.rights.driver.fl_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
_version_ 1800222917523406848