Antibacterial effect of isoeugenol against Pseudomonas aeruginosa

• Autor(a) principal: Galvão, José Lucas
• Data de Publicação: 2022
• Outros Autores: Silva Rosa, Lyvia Layanne, Neto, Hermes Diniz, Silva, Daniele de Figueredo, Nóbrega, Jefferson, Cordeiro, Laísa, Figueiredo, Pedro, de Andrade Júnior, Francisco Patricio, De Oliveira Filho, Abrahão Alves, Lima, Edeltrudes Oliveira
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Pharmaceutical Sciences
• Texto Completo: https://www.revistas.usp.br/bjps/article/view/205138
• topic: Pseudomonas aeruginosa; Isoeugenol; Antibacterial; Natural Product

Pseudomonas aeruginosa is an important nosocomial pathogen and its clinical importance is mainly related to nosocomial infections. Increased rates of bacterial resistance in recent years has led WHO to publish a global priority list to guide research and discovery of new antibiotics, where P. aeruginosa is among the group of bacteria for which there is a critical level of priority for new drugs to be discovered. In this context, isoeugenol appears as an interesting alternative and the objective of this study was to investigate its action against P. aeruginosa. Isoeugenol presented significant antibacterial activity, with minimum inhibitory concentration (MIC) of 64µg/mL and minimum bactericidal concentration (MBC) of 128µg/mL, and was considered bactericidal against this species. Molecular docking revealed interactions that suggest that isoeugenol may bind to the enzyme Penicillin-Binding Protein 3 and interfere with the bacterial cell wall synthesis process. This study reinforces the antibacterial potential of this compound and emphasizes that more studies are needed in order to better investigate its mechanism of antibacterial action.