Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/128353 |
Resumo: | The present research work was envisaged to develop bilayer tablets to improve therapeutic efficacy of antibiotic combination for the treatment of sexually transmitted diseases. The combination of two antibiotics i.e. cefixime trihydrate and ofloxacin were used for the preparation of bilayer tablets which act against genito-urinary infections. The formulations comprise of cefixime trihydrate as immediate release layer formulated using different superdisintegrants and ofloxacin as extended release layer containing HPMC K100M. Evaluation of bilayer tablets were performed for the immediate release cefixime layer and sustain release ofloxacin layer with optimization of excipients. The immediate release layer of cefixime showed complete release within 30 min and ofloxacin release was extended up to 24 hours. The similarity factor value of ofloxacin sustained release layer was found to be 87.01 for initial and 80.35 after 3 months stability when compared with marketed reference product. The present study revealed that cefixime trihydrate and ofloxacin bilayer tablets were successfully developed for the use against sexually transmitted infections. |
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oai:revistas.usp.br:article/128353 |
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Brazilian Journal of Pharmaceutical Sciences |
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Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease The present research work was envisaged to develop bilayer tablets to improve therapeutic efficacy of antibiotic combination for the treatment of sexually transmitted diseases. The combination of two antibiotics i.e. cefixime trihydrate and ofloxacin were used for the preparation of bilayer tablets which act against genito-urinary infections. The formulations comprise of cefixime trihydrate as immediate release layer formulated using different superdisintegrants and ofloxacin as extended release layer containing HPMC K100M. Evaluation of bilayer tablets were performed for the immediate release cefixime layer and sustain release ofloxacin layer with optimization of excipients. The immediate release layer of cefixime showed complete release within 30 min and ofloxacin release was extended up to 24 hours. The similarity factor value of ofloxacin sustained release layer was found to be 87.01 for initial and 80.35 after 3 months stability when compared with marketed reference product. The present study revealed that cefixime trihydrate and ofloxacin bilayer tablets were successfully developed for the use against sexually transmitted infections. Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/12835310.1590/s1984-82502016000300020Brazilian Journal of Pharmaceutical Sciences; Vol. 52 Núm. 3 (2016); 555-566Brazilian Journal of Pharmaceutical Sciences; v. 52 n. 3 (2016); 555-566Brazilian Journal of Pharmaceutical Sciences; Vol. 52 No. 3 (2016); 555-5662175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/128353/125225Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessGaikwad, Swati SanjayChafle, Sandip AnnajiMorris, Princy SunilAvari, Jasmine Gev2017-03-16T17:54:51Zoai:revistas.usp.br:article/128353Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2017-03-16T17:54:51Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease |
title |
Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease |
spellingShingle |
Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease Gaikwad, Swati Sanjay |
title_short |
Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease |
title_full |
Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease |
title_fullStr |
Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease |
title_full_unstemmed |
Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease |
title_sort |
Development and evaluation of bilayer tablets of combination of antibiotics for the treatment of sexually transmitted disease |
author |
Gaikwad, Swati Sanjay |
author_facet |
Gaikwad, Swati Sanjay Chafle, Sandip Annaji Morris, Princy Sunil Avari, Jasmine Gev |
author_role |
author |
author2 |
Chafle, Sandip Annaji Morris, Princy Sunil Avari, Jasmine Gev |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Gaikwad, Swati Sanjay Chafle, Sandip Annaji Morris, Princy Sunil Avari, Jasmine Gev |
description |
The present research work was envisaged to develop bilayer tablets to improve therapeutic efficacy of antibiotic combination for the treatment of sexually transmitted diseases. The combination of two antibiotics i.e. cefixime trihydrate and ofloxacin were used for the preparation of bilayer tablets which act against genito-urinary infections. The formulations comprise of cefixime trihydrate as immediate release layer formulated using different superdisintegrants and ofloxacin as extended release layer containing HPMC K100M. Evaluation of bilayer tablets were performed for the immediate release cefixime layer and sustain release ofloxacin layer with optimization of excipients. The immediate release layer of cefixime showed complete release within 30 min and ofloxacin release was extended up to 24 hours. The similarity factor value of ofloxacin sustained release layer was found to be 87.01 for initial and 80.35 after 3 months stability when compared with marketed reference product. The present study revealed that cefixime trihydrate and ofloxacin bilayer tablets were successfully developed for the use against sexually transmitted infections. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/128353 10.1590/s1984-82502016000300020 |
url |
https://www.revistas.usp.br/bjps/article/view/128353 |
identifier_str_mv |
10.1590/s1984-82502016000300020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/128353/125225 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 52 Núm. 3 (2016); 555-566 Brazilian Journal of Pharmaceutical Sciences; v. 52 n. 3 (2016); 555-566 Brazilian Journal of Pharmaceutical Sciences; Vol. 52 No. 3 (2016); 555-566 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222912846757888 |