Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection

Detalhes bibliográficos
Autor(a) principal: Requena Nocchi, Samara
Data de Publicação: 2022
Outros Autores: dos Anjos Oliveira Ferreira, Lilian, Vizioli de Castro-Hoshino, Lidiane, Torrado Truiti, Maria da Conceição, Marçal Natali, Maria Raquel, Palazzo de Mello, João Carlos, Baesso, Mauro Luciano, Prado Dias Filho, Benedito, Vataru Nakamura, Celso, Ueda-Nakamura, Tânia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/205070
Resumo: The therapeutic drugs to treat Herpes simplex virus (HSV) infections have toxic side effects and there has been an emergence of drug-resistant strains. Therefore, the search for new treatments for HSV infections is mounting. In the present study, semi-solid formulations containing a crude hydroethanolic extract (CHE) from Schinus terebinthifolia were developed. Skin irritation, cutaneous permeation, and in vivo therapeutic efficacy of the formulations were investigated. Treatment with the ointment formulations did not result in any signs of skin irritation while the emulsions increased the thickness of the epidermis in Swiss mice. The cutaneous permeation test indicated that the CHE incorporated in the formulations permeated through the skin layers and was present in the epidermis and dermis even 3 h after topical application. In vivo antiviral activity in BALB/c mice treated with the CHE ointments was better than those treated with the CHE emulsions and did not significantly differ from an acyclovir-treated group. Taken together, this suggests that the incorporation of CHE in the ointment may be a potential candidate for the alternative topical treatment of herpetic lesions.
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spelling Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infectionHSV-1Schinus terebinthifoliaTopical formulationsSkin irritationPhotoacousticIn vivo efficacyThe therapeutic drugs to treat Herpes simplex virus (HSV) infections have toxic side effects and there has been an emergence of drug-resistant strains. Therefore, the search for new treatments for HSV infections is mounting. In the present study, semi-solid formulations containing a crude hydroethanolic extract (CHE) from Schinus terebinthifolia were developed. Skin irritation, cutaneous permeation, and in vivo therapeutic efficacy of the formulations were investigated. Treatment with the ointment formulations did not result in any signs of skin irritation while the emulsions increased the thickness of the epidermis in Swiss mice. The cutaneous permeation test indicated that the CHE incorporated in the formulations permeated through the skin layers and was present in the epidermis and dermis even 3 h after topical application. In vivo antiviral activity in BALB/c mice treated with the CHE ointments was better than those treated with the CHE emulsions and did not significantly differ from an acyclovir-treated group. Taken together, this suggests that the incorporation of CHE in the ointment may be a potential candidate for the alternative topical treatment of herpetic lesions.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2022-11-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20507010.1590/s2175-97902020000318637 Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/205070/194458Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRequena Nocchi, Samarados Anjos Oliveira Ferreira, LilianVizioli de Castro-Hoshino, LidianeTorrado Truiti, Maria da ConceiçãoMarçal Natali, Maria RaquelPalazzo de Mello, João CarlosBaesso, Mauro LucianoPrado Dias Filho, BeneditoVataru Nakamura, CelsoUeda-Nakamura, Tânia2023-05-25T13:32:08Zoai:revistas.usp.br:article/205070Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-05-25T13:32:08Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
title Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
spellingShingle Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
Requena Nocchi, Samara
HSV-1
Schinus terebinthifolia
Topical formulations
Skin irritation
Photoacoustic
In vivo efficacy
title_short Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
title_full Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
title_fullStr Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
title_full_unstemmed Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
title_sort Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
author Requena Nocchi, Samara
author_facet Requena Nocchi, Samara
dos Anjos Oliveira Ferreira, Lilian
Vizioli de Castro-Hoshino, Lidiane
Torrado Truiti, Maria da Conceição
Marçal Natali, Maria Raquel
Palazzo de Mello, João Carlos
Baesso, Mauro Luciano
Prado Dias Filho, Benedito
Vataru Nakamura, Celso
Ueda-Nakamura, Tânia
author_role author
author2 dos Anjos Oliveira Ferreira, Lilian
Vizioli de Castro-Hoshino, Lidiane
Torrado Truiti, Maria da Conceição
Marçal Natali, Maria Raquel
Palazzo de Mello, João Carlos
Baesso, Mauro Luciano
Prado Dias Filho, Benedito
Vataru Nakamura, Celso
Ueda-Nakamura, Tânia
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Requena Nocchi, Samara
dos Anjos Oliveira Ferreira, Lilian
Vizioli de Castro-Hoshino, Lidiane
Torrado Truiti, Maria da Conceição
Marçal Natali, Maria Raquel
Palazzo de Mello, João Carlos
Baesso, Mauro Luciano
Prado Dias Filho, Benedito
Vataru Nakamura, Celso
Ueda-Nakamura, Tânia
dc.subject.por.fl_str_mv HSV-1
Schinus terebinthifolia
Topical formulations
Skin irritation
Photoacoustic
In vivo efficacy
topic HSV-1
Schinus terebinthifolia
Topical formulations
Skin irritation
Photoacoustic
In vivo efficacy
description The therapeutic drugs to treat Herpes simplex virus (HSV) infections have toxic side effects and there has been an emergence of drug-resistant strains. Therefore, the search for new treatments for HSV infections is mounting. In the present study, semi-solid formulations containing a crude hydroethanolic extract (CHE) from Schinus terebinthifolia were developed. Skin irritation, cutaneous permeation, and in vivo therapeutic efficacy of the formulations were investigated. Treatment with the ointment formulations did not result in any signs of skin irritation while the emulsions increased the thickness of the epidermis in Swiss mice. The cutaneous permeation test indicated that the CHE incorporated in the formulations permeated through the skin layers and was present in the epidermis and dermis even 3 h after topical application. In vivo antiviral activity in BALB/c mice treated with the CHE ointments was better than those treated with the CHE emulsions and did not significantly differ from an acyclovir-treated group. Taken together, this suggests that the incorporation of CHE in the ointment may be a potential candidate for the alternative topical treatment of herpetic lesions.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/205070
10.1590/s2175-97902020000318637
url https://www.revistas.usp.br/bjps/article/view/205070
identifier_str_mv 10.1590/s2175-97902020000318637
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/205070/194458
dc.rights.driver.fl_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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